The TAOK family is a group of serine/threonine kinases, including three members: TAOK1, TAOK2, and TAOK3. They consist of a kinase domain and a conserved C-terminal domain, primarily located in the cytoplasm and nucleus. The TAOK family plays a crucial role in regulating cell cytoskeleton reorganization, cell cycle progression, and cell stress response. By activating the MAPK signaling pathways, such as JNK and p38 MAPK, they influence cell stress response and survival. The expression of the TAOK family is specific in different tissues and cells, and mutations or dysregulation in their gene expression are associated with various diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases.