Home Chemistry Heterocyclic Building Blocks Indoles 2-(1H-Indol-3-Yl)Ethan-1-Ol
Nucleophilic Substitution: The hydroxyl group can participate in nucleophilic substitution reactions. For example, it can react with acid chlorides or anhydrides to formesters or with alkyl halides to form ethers.
Oxidation: The alcohol group can undergo oxidation to form the corresponding aldehyde or carboxylic acid.
Ether Formation: The alcohol group can react with acid chlorides or alkyl halides to form ethers.
Acetylation: The hydroxyl group may undergo acetylation with acetyl chloride or acetic anhydride to form an acetate ester.
Indole Ring Reactions: The indole ring can participate in various reactions, including electrophilic aromatic substitution. For instance, it may undergo Friedel-Crafts acylation or alkylation reactions.
Reduction: The carbonyl group (if formed through oxidation) can be reduced back to the alcohol using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Condensation Reactions: The alcohol and indole functionalities may participate in condensation reactions to form larger molecules, such as Schiff bases or imines.
Esterification: The alcohol group can react with carboxylic acids or acid chlorides to form esters.
Grignard Reaction: The compound may react with a Grignard reagent to form a tertiary alcohol.
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Methyl 3-(2-hydroxyethyl)-1H-indole-5-carboxylate
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