c-Met, also known as hepatocyte growth factor receptor (HGFR), is a part of the receptor tyrosine kinase family, with a structure comprising extracellular Sema and PSI domains, a transmembrane region, and an intracellular kinase domain. It is primarily expressed in epithelial cells and is activated by binding to its ligand, HGF, participating in the regulation of various biological processes such as cell proliferation, differentiation, migration, and survival. c-Met signaling is transmitted through the MAPK, PI3K/AKT, and STAT pathways, playing a crucial role in organ development and regeneration. The specific expression and mutations of the c-Met gene, especially activating mutations, are closely associated with the occurrence and development of various cancers, making c-Met an important target for targeted therapy.