Home Chemistry Heterocyclic Building Blocks Thiophenes 4,4,5,5-Tetramethyl-2-(Thiophen-3-Yl)-1,3,2-Dioxaborolane
Suzuki Coupling: Boronic esters like this one can participate in Suzuki coupling reactions with aryl halides or triflates in the presence of a palladium catalyst. This reaction forms carbon-carbon bonds, often used in the synthesis of complex organic molecules.
Hydrolysis: The boron-oxygen bond in the boronic ester can be cleaved by hydrolysis, converting it to the corresponding boronic acid.
Oxidation: The boron atom can be oxidized to a boronic acid or boronate ester using various oxidizing agents.
Cross-coupling reactions: Thiophenes, in general, can participate in a variety of cross-coupling reactions, such as Kumada, Stille, and Heck reactions, depending on the functional groups present on the molecule.
Functionalization: The thiophene ring can be further functionalized through various reactions like halogenation, sulfonation, or nitration.
Reductive transformations: The boron atom can be reduced to boronate esters or boranes using reducing agents.
Protection/deprotection: The compound may undergo protection reactions, such as the formation of boronate esters, and subsequent deprotection when needed in a synthesis.
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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methanol
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxamide
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid
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Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde
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2-(2,5-Dimethylthiophen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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tert-Butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methoxy)silane
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