mitoNEET is a mitochondrial outer membrane protein and belongs to the CDGSH iron-sulfur protein family. It is characterized by containing two [2Fe-2S] iron-sulfur centers, which are crucial for regulating iron transport and storage. The primary function of this protein in cells is to regulate mitochondrial electron transport and energy metabolism, essential for maintaining cellular redox balance. mitoNEET's expression is tissue-specific and associated with various metabolic diseases such as diabetes and cardiovascular diseases. Mutations or abnormal expression of the gene can lead to dysfunction, affecting cellular energy balance and health.