Home Chemistry Heterocyclic Building Blocks Indazoles 4-Chloro-1H-Indazole
Nucleophilic Substitution: The chlorine atom can undergo nucleophilic substitution reactions with various nucleophiles, leading to the formation of substituted indazoles.
Metalation: The indazole ring can be deprotonated by strong bases to form metal indazolides, which can then undergo various reactions such as nucleophilic addition or substitution.
Electrophilic Substitution: The electron-rich aromatic ring of indazole can undergo electrophilic aromatic substitution reactions with electrophiles such as nitration, halogenation, sulfonation, or Friedel-Crafts acylation and alkylation.
Ring Closure Reactions: indazole can undergo ring closure reactions with appropriate reagents to form fused ring systems or heterocyclic compounds.
Reduction: The nitro group of 4-chloro-1H-indazole can be reduced to the corresponding amine using reducing agents such as tin(II) chloride and hydrochloric acid, or catalytic hydrogenation.
Oxidation: indazole can undergo oxidation reactions to form indazole N-oxide derivatives under suitable conditions.
Halogenation: indazole can undergo further halogenation reactions at positions adjacent to the chloro group, depending on the reaction conditions and reagents used.
Functional Group Interconversions: Various functional groups present in 4-chloro-1H-indazole can be interconverted through appropriate chemical reactions such as reduction, oxidation, or substitution.
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Methyl 4-chloro-1H-indazole-6-carboxylate
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