GPR52 is a member of the G protein-coupled receptor family, characterized by seven transmembrane domains. It is primarily expressed in the brain, especially in the striatum and hippocampus. GPR52 is involved in regulating dopamine signaling and neuronal excitability, influencing cognitive and motor functions. Its specific expression and functional regulation are crucial for the occurrence and treatment of neuropsychiatric disorders. Mutations or aberrant expression of GPR52 are associated with the development of neuropsychiatric disorders such as schizophrenia, Parkinson's disease, and cognitive impairment.