Chemistry Organic building blocks Ethers Tert-butoxybenzene

Tert-butoxybenzene

These compounds have the same murcko framework: benzene,and at least 1 kind of functional groups( —OC(CH3)3).

Nucleophilic Substitution at the Tert-Butyl Group: The tert-butyl group is a bulky alkyl group that can be a target for nucleophilic substitution reactions. If you have a strong nucleophile (e.g., OH-, CN-, or NH2-), it can attack the carbon atom bonded to the oxygen atom of the tert-butyl group, leading to substitution of the tert-butyl group with the nucleophile.

Further Reading:

Framework+−

(1s,4ar,7ar)-1-(((s)-tetrahydro-2h-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran (2,2,2-trifluoroethoxy)benzene (2-(benzyloxy)phenyl)boronic acid (2-(phenoxymethyl)phenyl)boronic acid (2-chloro-3-methoxyphenyl)boronic acid (2-chloroethoxy)benzene (2-methoxyethoxy)benzene (3-(benzyloxy)phenyl)boronic acid (3-(phenoxymethyl)phenyl)boronic acid (3-chloro-2-methoxyphenyl)boronic acid (3-phenoxyphenyl)methanol (4-(benzyloxy)phenyl)boronic acid (4-(phenoxymethyl)phenyl)boronic acid (4-methoxyphenyl)(phenyl)methanone (9h-fluoren-9-yl)methyl (2-(benzyloxy)ethyl)carbamate (9h-fluoren-9-yl)methyl (4-methoxybenzyl)carbamate (allyloxy)benzene (ethoxymethyl)benzene (hexyloxy)benzene (methoxymethyl)benzene (prop-2-yn-1-yloxy)benzene (r)-2-phenoxytetrahydro-2h-pyran (s)-7-(((s)-tetrahydro-2h-pyran-2-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione 1,2-bis(benzyloxy)benzene 1,2-dichloro-3-methoxybenzene 1,2-dichloro-4-methoxybenzene 1,2-difluoro-3-methoxybenzene 1,2-difluoro-4-methoxybenzene 1,2-dimethoxybenzene 1,2-diphenoxyethane 1,3-bis(benzyloxy)benzene 1,3-dibromo-2-methoxybenzene 1,3-dichloro-2-methoxybenzene 1,3-diiodo-2-phenoxybenzene 1,3-dimethoxybenzene 1,3-diphenoxybenzene 1,4-dichloro-2-methoxybenzene 1,4-dimethoxybenzene 1-(2-methoxyphenyl)ethan-1-one 1-(3-(benzyloxy)phenyl)ethan-1-one 1-(3-methoxyphenyl)ethan-1-one 1-(3-methoxyphenyl)piperazine 1-(4-(benzyloxy)phenyl)ethan-1-one 1-(4-methoxybenzyl)-1h-pyrazole 1-(benzyloxy)-2-bromobenzene 1-(benzyloxy)-2-chlorobenzene 1-(benzyloxy)-2-fluorobenzene 1-(benzyloxy)-2-methoxybenzene 1-(benzyloxy)-2-methylbenzene 1-(benzyloxy)-2-nitrobenzene 1-(benzyloxy)-3-bromobenzene 1-(benzyloxy)-3-chlorobenzene 1-(benzyloxy)-3-fluorobenzene 1-(benzyloxy)-3-methylbenzene 1-(benzyloxy)-3-nitrobenzene 1-(benzyloxy)-4-bromobenzene 1-(benzyloxy)-4-iodobenzene 1-(bromomethyl)-2-methoxybenzene 1-(bromomethyl)-3-methoxybenzene 1-(difluoromethoxy)-2-fluorobenzene 1-benzyl-4-methoxybenzene 1-bromo-2,3-dimethoxybenzene 1-bromo-2-chloro-3-methoxybenzene 1-bromo-2-ethoxybenzene 1-bromo-2-fluoro-3-methoxybenzene 1-bromo-2-phenoxybenzene 1-bromo-3-methoxybenzene 1-bromo-3-phenoxybenzene 1-bromo-4-phenoxybenzene 1-chloro-2,4-dimethoxybenzene 1-chloro-2-ethoxybenzene 1-chloro-2-phenoxybenzene 1-chloro-2-propoxybenzene 1-chloro-3-fluoro-2-methoxybenzene 1-chloro-3-methoxybenzene 1-chloro-3-phenoxybenzene 1-chloro-4-methoxybenzene 1-chloro-4-phenoxybenzene 1-cyclopropyl-3-(4-(quinolin-4-yloxy)phenyl)urea 1-ethoxy-2,3-difluorobenzene 1-ethoxy-2-fluorobenzene 1-ethoxy-3-nitrobenzene 1-fluoro-2-(trifluoromethoxy)benzene 1-fluoro-2-isopropoxybenzene 1-fluoro-2-phenoxybenzene 1-fluoro-3-methoxybenzene 1-fluoro-3-phenoxybenzene 1-fluoro-4-(trifluoromethoxy)benzene 1-fluoro-4-methoxybenzene 1-fluoro-4-phenoxybenzene 1-iodo-2-methoxybenzene 1-iodo-3-methoxybenzene 1-iodo-4-methoxybenzene 1-iodo-4-phenoxybenzene 1-methoxy-2-(trifluoromethyl)benzene 1-methoxy-3-(trifluoromethoxy)benzene 1-methoxy-3-(trifluoromethyl)benzene 1-methoxy-3-nitrobenzene 1-methoxy-4-(phenoxymethyl)benzene 1-methoxy-4-(trifluoromethyl)benzene 1-methoxy-4-nitrobenzene 1-methoxynaphthalene 1-methyl-3-phenoxybenzene 1-nitro-2-phenoxybenzene 1-nitro-4-phenoxybenzene 1-phenoxy-3-(trifluoromethyl)benzene 1-phenoxy-4-(trifluoromethyl)benzene 1-phenyl-3-(4-(pyridin-4-yloxy)phenyl)urea 2,3,5,6,8,9,11,12-octahydrobenzo[b][1,4,7,10,13]pentaoxacyclopentadecine 2,3-dimethoxypyridine 2,4,6-triphenoxy-1,3,5-triazine 2,4-dibromo-1-methoxybenzene 2,4-dichloro-1-methoxybenzene 2,4-difluoro-1-methoxybenzene 2,4-dimethoxy-1-nitrobenzene 2,4-dimethoxypyrimidine 2,6-dimethoxypyridine 2-(2-methoxyphenyl)acetic acid 2-(3-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(3-methoxyphenyl)acetic acid 2-(4-(benzyloxy)phenyl)acetonitrile 2-(4-methoxyphenyl)acetic acid 2-(benzyloxy)benzaldehyde 2-(benzyloxy)naphthalene 2-(benzyloxy)phenol 2-(methoxymethyl)morpholine 2-(methoxymethyl)pyrrolidine 2-(phenoxymethyl)oxirane 2-(phenoxymethyl)pyridine 2-(phenoxymethyl)tetrahydro-2h-pyran 2-bromo-1,3-dimethoxybenzene 2-bromo-1,4-dimethoxybenzene 2-bromo-1-fluoro-4-methoxybenzene 2-bromo-1-methoxy-3-methylbenzene 2-bromo-1-methoxy-4-methylbenzene 2-bromo-3-methoxypyrazine 2-bromo-4-methoxy-1-nitrobenzene 2-bromo-4-methoxyaniline 2-bromo-4-methoxybenzaldehyde 2-bromo-4-methoxybenzoic acid 2-bromo-5-methoxybenzaldehyde 2-bromo-6-methoxyaniline 2-bromo-6-methoxyphenol 2-chloro-1,3-dimethoxybenzene 2-chloro-1,4-dimethoxybenzene 2-chloro-3-methoxybenzaldehyde 2-chloro-3-methoxybenzoic acid 2-chloro-4-fluoro-1-methoxybenzene 2-chloro-4-methoxypyrimidine 2-chloro-5-methoxyaniline 2-chloro-6-methoxyaniline 2-chloro-6-methoxyphenol 2-ethoxynaphthalene 2-ethoxypyridine 2-ethoxypyrimidine 2-fluoro-1,3-dimethoxybenzene 2-fluoro-1-methoxy-4-nitrobenzene 2-fluoro-4-methoxyaniline 2-fluoro-5-methoxybenzoic acid 2-fluoro-5-methoxypyridine 2-fluoro-6-methoxypyridine 2-isopropoxypyridine 2-methoxy-1,1'-biphenyl 2-methoxy-1,3,5-triazine 2-methoxy-4-methylpyridine 2-methoxy-5-methylpyridine 2-methoxy-6-methylpyridine 2-methoxy-6-nitrophenol 2-methoxybenzamide 2-methoxybenzenesulfonyl chloride 2-methoxynaphthalene 2-methoxyphenol 2-methoxypyrazine 2-methoxypyridine 2-methoxypyrimidin-4-amine 2-methoxypyrimidine 2-methoxythiophene 2-methyl-n-phenylaniline 2-phenoxyacetonitrile 2-phenoxyaniline 2-phenoxybenzonitrile 2-phenoxyethan-1-ol 2-phenoxypropanoic acid 2-phenoxypyrimidine 2-phenoxytetrahydro-2h-pyran 2-phenoxythiazole 2-propoxypyridine 3,5-dimethoxypyridine 3-(3-methoxyphenyl)propanoic acid 3-(benzyloxy)aniline 3-(benzyloxy)benzaldehyde 3-(benzyloxy)benzoic acid 3-(benzyloxy)phenol 3-(methoxymethyl)morpholine 3-chloro-2-methoxybenzoic acid 3-chloro-4-methoxyaniline 3-chloro-4-methoxybenzaldehyde 3-chloro-4-methoxybenzoic acid 3-ethoxypyridine 3-fluoro-2-methoxypyridine 3-fluoro-4-methoxybenzoic acid 3-methoxypiperidine 3-methoxypyridazine 3-methoxypyridine 3-methoxythiophene 3-phenoxyaniline 3-phenoxybenzaldehyde 3-phenoxybenzoic acid 3-phenoxybenzonitrile 3-phenoxypropanoic acid 3-phenoxypyrrolidine 4-(3-phenoxypropyl)morpholine 4-(benzyloxy)aniline 4-(benzyloxy)benzaldehyde 4-(benzyloxy)benzoic acid 4-(benzyloxy)phenol 4-(difluoromethoxy)aniline 4-(dimethoxymethyl)pyrimidine 4-(phenylethynyl)phenol 4-chloro-2-methoxypyrimidine 4-chloro-5-methoxypyrimidine 4-chloro-6-methoxypyrimidine 4-ethoxypyridine 4-ethoxypyrimidine 4-methoxy-1,1'-biphenyl 4-methoxy-1h-indazole 4-methoxy-1h-indole 4-methoxy-2-methylpyrimidine 4-methoxy-n-phenylaniline 4-methoxy-n-phenylbenzenesulfonamide 4-methoxybenzenesulfonamide 4-methoxypyridazine 4-methoxypyridine 4-methoxypyrimidin-2-amine 4-methoxypyrimidine 4-phenoxyaniline 4-phenoxybenzaldehyde 4-phenoxybenzoic acid 4-phenoxypyridine 4-phenoxypyrimidine 4-phenoxyquinoline 4-phenoxytetrahydro-2h-pyran 5-(benzyloxy)pyrimidine 5-fluoro-2-methoxypyridine 5-methoxy-1h-benzo[d]imidazole 5-methoxy-1h-indazole 5-methoxy-1h-indole 5-methoxy-2-methyl-1h-indole 5-methoxy-2-nitroaniline 5-methoxyindoline 5-methoxyisobenzofuran-1(3h)-one 5-methoxyisoquinoline 6-methoxy-1,2,3,4-tetrahydroisoquinoline 6-methoxy-1h-indazole 6-methoxy-1h-indole 6-methoxy-1h-pyrrolo[2,3-b]pyridine 6-methoxy-3,4-dihydroisoquinolin-1(2h)-one 6-methoxybenzo[d]thiazole 6-methoxybenzofuran 6-methoxychromane 6-methoxyisoindolin-1-one 6-methoxyquinoxaline 7-(benzyloxy)quinoline 7-methoxy-1,2,3,4-tetrahydroisoquinoline 7-methoxy-1h-indazole 7-methoxy-1h-indole 7-methoxy-3,4-dihydroquinolin-2(1h)-one 7-methoxyisoquinoline 8-methoxyisoquinoline 8-methoxyquinazoline Butoxybenzene Ethoxybenzene Ethyl 2-phenoxyacetate Isobutoxybenzene Isopropoxybenzene Methoxycyclohexane Methyl 2-methoxybenzoate Methyl 2-phenoxyacetate Methyl 2-phenoxybenzoate Methyl 3-(benzyloxy)benzoate Methyl 3-methoxybenzoate Methyl 4-phenoxybenzoate N,n-dimethyl-2-phenoxyethan-1-amine N-(2-phenoxyphenyl)methanesulfonamide N-(4-phenoxyphenyl)acetamide N-phenyl-n-(4-(quinolin-4-yloxy)phenyl)cyclopropane-1,1-dicarboxamide Phenethoxybenzene Propoxybenzene Tert-butoxybenzene Tert-butyl 3-methoxypyrrolidine-1-carboxylate Tert-butyl 4-phenoxypiperidine-1-carboxylate Tert-butyl 5-methoxy-1h-indole-1-carboxylate

By Key Group+−

(2-ethylhexyl)oxy (s)-2-methoxyethanamine (trimethylsilyl)ethoxy 2,2,2-trifluoroethoxy 2,2-difluoroethoxy 2,2-dimethoxyethyl 2-bromo-1,1,2,2-tetrafluoroethoxy 2-bromoethoxy 2-methoxyethoxy 2-methoxyethoxymethyl 2-methoxyethyl 2-methyl-2-oxypropanoic acid 2-oxoacetic acid 2-oxy-propanoic acid 3-(oxy)propanoic acid 3-methoxypropoxy 4-bromobutoxy Allyloxy Benzo-crown-ether Butoxy Butoxy-phenyl-boronic acid Butoxy-phenyl-boronic acid/ester Butoxy-phenyl-boronic-acid Chloroanisole Cyanomethoxy Decyloxy Diethoxy Diethoxy Diethoxyethyl Diethoxyethyl Diethoxymethyl Diethoxymethyl Diethylaminoethoxy Dimethoxyethyl Dimethoxymethyl Dimethoxypropane Dimethoxypropane Dimethylamino ethoxy Dimethylaminopropoxy Dioxane Dioxepine Dioxepine Dioxopropan Dioxopropan Disulfide Dodecyloxy Ethoxyethanol Ethyl 2-oxyacetate Fluoromethoxy-nitro-benzene Heptyloxy Hexyloxy Isobutoxy Isopentyloxy Isopropoxy Isopropoxyphenylboronic Methoxy-acetic acid Methoxy-benzoimidazole Methoxy-carbazole Methoxy-chromen-one Methoxy-indanone Methoxy-indazole-carboxylate Methoxy-inden-amine Methoxy-indole-carboxylate Methoxy-methyl-indole Methoxy-methylbenzene Methoxy-naphthyridine Methoxy-pyran Methoxy-pyrazolo-pyridine Methoxy-trifluoromethyl-benzene Methoxyacetate Methoxychroman Methoxyethoxyethoxyethoxy Methoxyphenylboronic-acid Methyl 2-oxy-acetate Nitroanisole Octyloxy Oxy ethanamine Oxy-acetohydrazide Oxyacetic acid Oxypropane-1,2-dio Prop-2-yn-1-oxy Propoxy Tert-butoxy Tert-butoxybromobenzene Tert-butoxymethyl Tetrahydroquinoline-methoxy

By Parent Nucleus+−

Aliphatic heterocycles Aromatic heterocycles Azetidines Benzimidazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Carbazoles Dioxolanes Epoxides Furans Guanidines Imidazoles Imidazolines Indazoles Indoles Indolines Isoquinolines Isoxazoles Morpholines Naphthyridines Non-halogenated heterocycles Other aliphatic heterocycles Other aromatic heterocycles Oxadiazoles Oxazoles Oxazolidines Oxetanes Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Quinuclidines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Thiadiazoles Thiazoles Thiazolidines Thiophenols Triazines Triazoles

By Functional Group+−

acyl chlorides alcohols aldehydes aliphatic chain hydrocarbons aliphatic cyclic hydrocarbons alkenyls alkyls alkynyls Amides amidines Amines anhydrides Aryls benzyl bromides benzyl chlorides Bromides carboxylic acid salts carboxylic acids Chiral building blocks Chlorides difluoromethyls Esters Fluorinated building blocks hydrazides hydrazines hydrazones hydroxylamines iodides isocyanates and isothiocyanates ketones nitrates and nitrites nitriles nitroes phenols phosphoruses sulfamides sulfides sulfonates sulfones sulfonic acids sulfonyl chlorides sulfoxides thioesters thiols Thiophenes thioureas trifluoromethyls ureas

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