Chemistry Organic building blocks Ethers Phenethoxybenzene

Phenethoxybenzene

Williamson Ether Synthesis: Phenetole can be synthesized using the Williamson ether synthesis by reacting a phenoxide ion (obtained from phenol) with ethyl halides (e.g., ethyl bromide or ethyl chloride) in the presence of a strong base like sodium hydroxide (NaOH). Acid-Catalyzed Cleavage: Phenetole can be cleaved by strong acids, such as concentrated hydrochloric acid or sulfuric acid. This reaction can lead to the formation of phenol and ethyl alcohol as products. Electrophilic Aromatic Substitution: The phenyl group in phenetole can undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, halogenation, or Friedel-Crafts acylation or alkylation. Oxidation: Phenetole can be oxidized to form different compounds, depending on the reagents and conditions used. Common oxidizing agents include hydrogen peroxide (H2O2) or potassium permanganate (KMnO4). Photolysis: Exposure to ultraviolet (UV) light can lead to the cleavage of the ether bond in phenetole, resulting in the formation of phenol and ethyl radicals. Reductive Cleavage: Under certain conditions, phenetole can undergo reductive cleavage reactions using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). Hydrolysis: Phenetole can be hydrolyzed in the presence of strong acids or bases to yield phenol and ethyl alcohol as products.

Further Reading:

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(1s,4ar,7ar)-1-(((s)-tetrahydro-2h-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran (2,2,2-trifluoroethoxy)benzene (2-(benzyloxy)phenyl)boronic acid (2-(phenoxymethyl)phenyl)boronic acid (2-chloro-3-methoxyphenyl)boronic acid (2-chloroethoxy)benzene (2-methoxyethoxy)benzene (3-(benzyloxy)phenyl)boronic acid (3-(phenoxymethyl)phenyl)boronic acid (3-chloro-2-methoxyphenyl)boronic acid (3-phenoxyphenyl)methanol (4-(benzyloxy)phenyl)boronic acid (4-(phenoxymethyl)phenyl)boronic acid (4-methoxyphenyl)(phenyl)methanone (9h-fluoren-9-yl)methyl (2-(benzyloxy)ethyl)carbamate (9h-fluoren-9-yl)methyl (4-methoxybenzyl)carbamate (allyloxy)benzene (ethoxymethyl)benzene (hexyloxy)benzene (methoxymethyl)benzene (prop-2-yn-1-yloxy)benzene (r)-2-phenoxytetrahydro-2h-pyran (s)-7-(((s)-tetrahydro-2h-pyran-2-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione 1,2-bis(benzyloxy)benzene 1,2-dichloro-3-methoxybenzene 1,2-dichloro-4-methoxybenzene 1,2-difluoro-3-methoxybenzene 1,2-difluoro-4-methoxybenzene 1,2-dimethoxybenzene 1,2-diphenoxyethane 1,3-bis(benzyloxy)benzene 1,3-dibromo-2-methoxybenzene 1,3-dichloro-2-methoxybenzene 1,3-diiodo-2-phenoxybenzene 1,3-dimethoxybenzene 1,3-diphenoxybenzene 1,4-dichloro-2-methoxybenzene 1,4-dimethoxybenzene 1-(2-methoxyphenyl)ethan-1-one 1-(3-(benzyloxy)phenyl)ethan-1-one 1-(3-methoxyphenyl)ethan-1-one 1-(3-methoxyphenyl)piperazine 1-(4-(benzyloxy)phenyl)ethan-1-one 1-(4-methoxybenzyl)-1h-pyrazole 1-(benzyloxy)-2-bromobenzene 1-(benzyloxy)-2-chlorobenzene 1-(benzyloxy)-2-fluorobenzene 1-(benzyloxy)-2-methoxybenzene 1-(benzyloxy)-2-methylbenzene 1-(benzyloxy)-2-nitrobenzene 1-(benzyloxy)-3-bromobenzene 1-(benzyloxy)-3-chlorobenzene 1-(benzyloxy)-3-fluorobenzene 1-(benzyloxy)-3-methylbenzene 1-(benzyloxy)-3-nitrobenzene 1-(benzyloxy)-4-bromobenzene 1-(benzyloxy)-4-iodobenzene 1-(bromomethyl)-2-methoxybenzene 1-(bromomethyl)-3-methoxybenzene 1-(difluoromethoxy)-2-fluorobenzene 1-benzyl-4-methoxybenzene 1-bromo-2,3-dimethoxybenzene 1-bromo-2-chloro-3-methoxybenzene 1-bromo-2-ethoxybenzene 1-bromo-2-fluoro-3-methoxybenzene 1-bromo-2-phenoxybenzene 1-bromo-3-methoxybenzene 1-bromo-3-phenoxybenzene 1-bromo-4-phenoxybenzene 1-chloro-2,4-dimethoxybenzene 1-chloro-2-ethoxybenzene 1-chloro-2-phenoxybenzene 1-chloro-2-propoxybenzene 1-chloro-3-fluoro-2-methoxybenzene 1-chloro-3-methoxybenzene 1-chloro-3-phenoxybenzene 1-chloro-4-methoxybenzene 1-chloro-4-phenoxybenzene 1-cyclopropyl-3-(4-(quinolin-4-yloxy)phenyl)urea 1-ethoxy-2,3-difluorobenzene 1-ethoxy-2-fluorobenzene 1-ethoxy-3-nitrobenzene 1-fluoro-2-(trifluoromethoxy)benzene 1-fluoro-2-isopropoxybenzene 1-fluoro-2-phenoxybenzene 1-fluoro-3-methoxybenzene 1-fluoro-3-phenoxybenzene 1-fluoro-4-(trifluoromethoxy)benzene 1-fluoro-4-methoxybenzene 1-fluoro-4-phenoxybenzene 1-iodo-2-methoxybenzene 1-iodo-3-methoxybenzene 1-iodo-4-methoxybenzene 1-iodo-4-phenoxybenzene 1-methoxy-2-(trifluoromethyl)benzene 1-methoxy-3-(trifluoromethoxy)benzene 1-methoxy-3-(trifluoromethyl)benzene 1-methoxy-3-nitrobenzene 1-methoxy-4-(phenoxymethyl)benzene 1-methoxy-4-(trifluoromethyl)benzene 1-methoxy-4-nitrobenzene 1-methoxynaphthalene 1-methyl-3-phenoxybenzene 1-nitro-2-phenoxybenzene 1-nitro-4-phenoxybenzene 1-phenoxy-3-(trifluoromethyl)benzene 1-phenoxy-4-(trifluoromethyl)benzene 1-phenyl-3-(4-(pyridin-4-yloxy)phenyl)urea 2,3,5,6,8,9,11,12-octahydrobenzo[b][1,4,7,10,13]pentaoxacyclopentadecine 2,3-dimethoxypyridine 2,4,6-triphenoxy-1,3,5-triazine 2,4-dibromo-1-methoxybenzene 2,4-dichloro-1-methoxybenzene 2,4-difluoro-1-methoxybenzene 2,4-dimethoxy-1-nitrobenzene 2,4-dimethoxypyrimidine 2,6-dimethoxypyridine 2-(2-methoxyphenyl)acetic acid 2-(3-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(3-methoxyphenyl)acetic acid 2-(4-(benzyloxy)phenyl)acetonitrile 2-(4-methoxyphenyl)acetic acid 2-(benzyloxy)benzaldehyde 2-(benzyloxy)naphthalene 2-(benzyloxy)phenol 2-(methoxymethyl)morpholine 2-(methoxymethyl)pyrrolidine 2-(phenoxymethyl)oxirane 2-(phenoxymethyl)pyridine 2-(phenoxymethyl)tetrahydro-2h-pyran 2-bromo-1,3-dimethoxybenzene 2-bromo-1,4-dimethoxybenzene 2-bromo-1-fluoro-4-methoxybenzene 2-bromo-1-methoxy-3-methylbenzene 2-bromo-1-methoxy-4-methylbenzene 2-bromo-3-methoxypyrazine 2-bromo-4-methoxy-1-nitrobenzene 2-bromo-4-methoxyaniline 2-bromo-4-methoxybenzaldehyde 2-bromo-4-methoxybenzoic acid 2-bromo-5-methoxybenzaldehyde 2-bromo-6-methoxyaniline 2-bromo-6-methoxyphenol 2-chloro-1,3-dimethoxybenzene 2-chloro-1,4-dimethoxybenzene 2-chloro-3-methoxybenzaldehyde 2-chloro-3-methoxybenzoic acid 2-chloro-4-fluoro-1-methoxybenzene 2-chloro-4-methoxypyrimidine 2-chloro-5-methoxyaniline 2-chloro-6-methoxyaniline 2-chloro-6-methoxyphenol 2-ethoxynaphthalene 2-ethoxypyridine 2-ethoxypyrimidine 2-fluoro-1,3-dimethoxybenzene 2-fluoro-1-methoxy-4-nitrobenzene 2-fluoro-4-methoxyaniline 2-fluoro-5-methoxybenzoic acid 2-fluoro-5-methoxypyridine 2-fluoro-6-methoxypyridine 2-isopropoxypyridine 2-methoxy-1,1'-biphenyl 2-methoxy-1,3,5-triazine 2-methoxy-4-methylpyridine 2-methoxy-5-methylpyridine 2-methoxy-6-methylpyridine 2-methoxy-6-nitrophenol 2-methoxybenzamide 2-methoxybenzenesulfonyl chloride 2-methoxynaphthalene 2-methoxyphenol 2-methoxypyrazine 2-methoxypyridine 2-methoxypyrimidin-4-amine 2-methoxypyrimidine 2-methoxythiophene 2-methyl-n-phenylaniline 2-phenoxyacetonitrile 2-phenoxyaniline 2-phenoxybenzonitrile 2-phenoxyethan-1-ol 2-phenoxypropanoic acid 2-phenoxypyrimidine 2-phenoxytetrahydro-2h-pyran 2-phenoxythiazole 2-propoxypyridine 3,5-dimethoxypyridine 3-(3-methoxyphenyl)propanoic acid 3-(benzyloxy)aniline 3-(benzyloxy)benzaldehyde 3-(benzyloxy)benzoic acid 3-(benzyloxy)phenol 3-(methoxymethyl)morpholine 3-chloro-2-methoxybenzoic acid 3-chloro-4-methoxyaniline 3-chloro-4-methoxybenzaldehyde 3-chloro-4-methoxybenzoic acid 3-ethoxypyridine 3-fluoro-2-methoxypyridine 3-fluoro-4-methoxybenzoic acid 3-methoxypiperidine 3-methoxypyridazine 3-methoxypyridine 3-methoxythiophene 3-phenoxyaniline 3-phenoxybenzaldehyde 3-phenoxybenzoic acid 3-phenoxybenzonitrile 3-phenoxypropanoic acid 3-phenoxypyrrolidine 4-(3-phenoxypropyl)morpholine 4-(benzyloxy)aniline 4-(benzyloxy)benzaldehyde 4-(benzyloxy)benzoic acid 4-(benzyloxy)phenol 4-(difluoromethoxy)aniline 4-(dimethoxymethyl)pyrimidine 4-(phenylethynyl)phenol 4-chloro-2-methoxypyrimidine 4-chloro-5-methoxypyrimidine 4-chloro-6-methoxypyrimidine 4-ethoxypyridine 4-ethoxypyrimidine 4-methoxy-1,1'-biphenyl 4-methoxy-1h-indazole 4-methoxy-1h-indole 4-methoxy-2-methylpyrimidine 4-methoxy-n-phenylaniline 4-methoxy-n-phenylbenzenesulfonamide 4-methoxybenzenesulfonamide 4-methoxypyridazine 4-methoxypyridine 4-methoxypyrimidin-2-amine 4-methoxypyrimidine 4-phenoxyaniline 4-phenoxybenzaldehyde 4-phenoxybenzoic acid 4-phenoxypyridine 4-phenoxypyrimidine 4-phenoxyquinoline 4-phenoxytetrahydro-2h-pyran 5-(benzyloxy)pyrimidine 5-fluoro-2-methoxypyridine 5-methoxy-1h-benzo[d]imidazole 5-methoxy-1h-indazole 5-methoxy-1h-indole 5-methoxy-2-methyl-1h-indole 5-methoxy-2-nitroaniline 5-methoxyindoline 5-methoxyisobenzofuran-1(3h)-one 5-methoxyisoquinoline 6-methoxy-1,2,3,4-tetrahydroisoquinoline 6-methoxy-1h-indazole 6-methoxy-1h-indole 6-methoxy-1h-pyrrolo[2,3-b]pyridine 6-methoxy-3,4-dihydroisoquinolin-1(2h)-one 6-methoxybenzo[d]thiazole 6-methoxybenzofuran 6-methoxychromane 6-methoxyisoindolin-1-one 6-methoxyquinoxaline 7-(benzyloxy)quinoline 7-methoxy-1,2,3,4-tetrahydroisoquinoline 7-methoxy-1h-indazole 7-methoxy-1h-indole 7-methoxy-3,4-dihydroquinolin-2(1h)-one 7-methoxyisoquinoline 8-methoxyisoquinoline 8-methoxyquinazoline Butoxybenzene Ethoxybenzene Ethyl 2-phenoxyacetate Isobutoxybenzene Isopropoxybenzene Methoxycyclohexane Methyl 2-methoxybenzoate Methyl 2-phenoxyacetate Methyl 2-phenoxybenzoate Methyl 3-(benzyloxy)benzoate Methyl 3-methoxybenzoate Methyl 4-phenoxybenzoate N,n-dimethyl-2-phenoxyethan-1-amine N-(2-phenoxyphenyl)methanesulfonamide N-(4-phenoxyphenyl)acetamide N-phenyl-n-(4-(quinolin-4-yloxy)phenyl)cyclopropane-1,1-dicarboxamide Phenethoxybenzene Propoxybenzene Tert-butoxybenzene Tert-butyl 3-methoxypyrrolidine-1-carboxylate Tert-butyl 4-phenoxypiperidine-1-carboxylate Tert-butyl 5-methoxy-1h-indole-1-carboxylate

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(2-ethylhexyl)oxy (s)-2-methoxyethanamine (trimethylsilyl)ethoxy 2,2,2-trifluoroethoxy 2,2-difluoroethoxy 2,2-dimethoxyethyl 2-bromo-1,1,2,2-tetrafluoroethoxy 2-bromoethoxy 2-methoxyethoxy 2-methoxyethoxymethyl 2-methoxyethyl 2-methyl-2-oxypropanoic acid 2-oxoacetic acid 2-oxy-propanoic acid 3-(oxy)propanoic acid 3-methoxypropoxy 4-bromobutoxy Allyloxy Benzo-crown-ether Butoxy Butoxy-phenyl-boronic acid Butoxy-phenyl-boronic acid/ester Butoxy-phenyl-boronic-acid Chloroanisole Cyanomethoxy Decyloxy Diethoxy Diethoxy Diethoxyethyl Diethoxyethyl Diethoxymethyl Diethoxymethyl Diethylaminoethoxy Dimethoxyethyl Dimethoxymethyl Dimethoxypropane Dimethoxypropane Dimethylamino ethoxy Dimethylaminopropoxy Dioxane Dioxepine Dioxepine Dioxopropan Dioxopropan Disulfide Dodecyloxy Ethoxyethanol Ethyl 2-oxyacetate Fluoromethoxy-nitro-benzene Heptyloxy Hexyloxy Isobutoxy Isopentyloxy Isopropoxy Isopropoxyphenylboronic Methoxy-acetic acid Methoxy-benzoimidazole Methoxy-carbazole Methoxy-chromen-one Methoxy-indanone Methoxy-indazole-carboxylate Methoxy-inden-amine Methoxy-indole-carboxylate Methoxy-methyl-indole Methoxy-methylbenzene Methoxy-naphthyridine Methoxy-pyran Methoxy-pyrazolo-pyridine Methoxy-trifluoromethyl-benzene Methoxyacetate Methoxychroman Methoxyethoxyethoxyethoxy Methoxyphenylboronic-acid Methyl 2-oxy-acetate Nitroanisole Octyloxy Oxy ethanamine Oxy-acetohydrazide Oxyacetic acid Oxypropane-1,2-dio Prop-2-yn-1-oxy Propoxy Tert-butoxy Tert-butoxybromobenzene Tert-butoxymethyl Tetrahydroquinoline-methoxy

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Aliphatic heterocycles Aromatic heterocycles Azetidines Benzimidazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Carbazoles Dioxolanes Epoxides Furans Guanidines Imidazoles Imidazolines Indazoles Indoles Indolines Isoquinolines Isoxazoles Morpholines Naphthyridines Non-halogenated heterocycles Other aliphatic heterocycles Other aromatic heterocycles Oxadiazoles Oxazoles Oxazolidines Oxetanes Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Quinuclidines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Thiadiazoles Thiazoles Thiazolidines Thiophenols Triazines Triazoles

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