Home Chemistry Heterocyclic Building Blocks Tetrahydropyrans (R)-2-Phenoxytetrahydro-2H-Pyran
Ether Cleavage: The phenoxy group can undergo ether cleavage reactions, leading to the formation of an alcohol and a phenol. This can be achieved by using strong acids or Lewis acids.
Epoxidation: The double bond in the tetrahydro-2H-pyran ring can be epoxidized using reagents like mCPBA (meta-chloroperoxybenzoic acid), which would form an epoxide ring.
Hydrogenation: The double bond in the tetrahydro-2H-pyran ring can be reduced to a single bond through hydrogenation using a catalyst like palladium on carbon (Pd/C) or hydrogen gas with a suitable catalyst.
Grignard Reaction: The molecule can react with a Grignard reagent, such as phenylmagnesium bromide (PhMgBr), to form a new carbon-carbon bond.
Oxidation: The alcohol group can be oxidized to a ketone or carboxylic acid using oxidizing agents like chromic acid (H2CrO4) or potassium permanganate (KMnO4).
Reduction: The ketone or carbonyl group, if formed, can be reduced to an alcohol using reducing agents like sodium borohydride (NaBH4).
Nucleophilic Substitution: Depending on the reaction conditions and the presence of suitable leaving groups, nucleophilic substitution reactions can occur at various positions within the molecule.
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