The Lats kinase family primarily includes Lats1 and Lats2, both featuring a kinase activity domain and a regulatory domain. These proteins are primarily localized in the cytoplasm and nucleus, playing a crucial role in regulating the cell cycle and apoptosis. Through the Hippo signaling pathway, Lats kinase regulates organ size and tissue growth by inhibiting the YAP/TAZ transcriptional co-activators, preventing excessive proliferation. The expression patterns in specific tissues and gene mutations are closely associated with the development of cancers and other diseases.