Home Chemistry Heterocyclic Building Blocks Oxadiazoles 1,2,4-Oxadiazole
Nitration: 1,2,4-oxadiazole can undergo nitration reactions to introduce nitro groups (-NO2) into the molecule. This can be achieved by treating it with a nitrating agent, such as concentrated nitric acid or a mixture of nitric and sulfuric acids.
Reduction: 1,2,4-oxadiazole can be reduced to its corresponding hydrazine derivative using reducing agents like hydrazine hydrate or catalytic hydrogenation.
Substitution Reactions: The nitrogen and oxygen atoms in the 1,2,4-oxadiazole ring can participate in nucleophilic substitution reactions. For example, they can react with electrophiles to form substituted oxadiazole derivatives.
Ring Opening Reactions: 1,2,4-Oxadiazole can undergo ring-opening reactions under certain conditions, leading to the formation of different compounds.
Cyclization Reactions: 1,2,4-Oxadiazole can participate in intramolecular cyclization reactions with suitable functional groups, leading to the formation of fused or bridged ring systems.
Oxidation: 1,2,4-Oxadiazole can be oxidized to its corresponding N-oxide or other oxidized products using appropriate oxidizing agents.
Rearrangements: Under specific conditions, rearrangement reactions can occur in the 1,2,4-oxadiazole ring, resulting in the formation of different isomers or products.
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Potassium 5-methyl-1,2,4-oxadiazole-3-carboxylate
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3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole
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3-(Chloromethyl)-5-ethyl-1,2,4-oxadiazole
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Ethyl 3-bromo-1,2,4-oxadiazole-5-carboxylate
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Ethyl 3-methyl-1,2,4-oxadiazole-5-carboxylate
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(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)methanamine hydrochloride
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(5-Methyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride
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{2-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]ethyl}amine hydrochloride
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2-(5-(tert-Butyl)-1,2,4-oxadiazol-3-yl)ethan-1-amine hydrochloride
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Ethyl 5-(tert-butyl)-1,2,4-oxadiazole-3-carboxylate
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Ethyl 5-methyl-1,2,4-oxadiazole-3-carboxylate
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Ethyl 5-amino-1,2,4-oxadiazole-3-carboxylate
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