Home Chemistry Organic Building Blocks Fluorinated Building Blocks 3-Fluorobenzamide
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—C(O)NH2).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Hofmann Rearrangement: Benzamide can undergo Hofmann rearrangement when treated with chlorine or bromine in the presence of a strong base, resulting in the conversion of the amide group to an 【isocyanate|https://www.ambeed.com/isocyanates-and-isothiocyanates.html】 group. Further hydrolysis of the isocyanate can yield an amine with one fewer carbon atom.
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2-Amino-4-bromo-3-fluoro-5-iodobenzamide
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(3-Carbamoyl-5-fluorophenyl)boronic acid
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