The Ryanodine Receptor-1 (RyR1) is a large calcium ion channel protein belonging to the RyR family, which includes RyR1, RyR2, and RyR3. RyR1 is primarily expressed on the sarcoplasmic reticulum of skeletal muscle, where it is responsible for regulating the release of calcium ions during muscle contraction. By interacting with various signaling molecules such as calcium, magnesium, and ATP, RyR1 is involved in intracellular calcium signaling and regulation of muscle contraction strength. The specific expression of the RyR1 gene is more pronounced in muscle tissue, and its mutations are associated with various muscle diseases, including malignant hyperthermia and central core disease.