Home Chemistry Heterocyclic Building Blocks Pyridines Picolinamide
Substitution Reactions: Picolinamide can undergo substitution reactions where one of the hydrogen atoms on the pyridine ring is replaced by another functional group. This can include nucleophilic substitution, electrophilic substitution, or radical substitution reactions.
Acylation Reactions: Picolinamide can undergo acylation reactions where an acyl group (-COR) is added onto the nitrogen atom or the oxygen atom of the amide group. This can be achieved using acyl chlorides, acid anhydrides, or esters in the presence of appropriate catalysts.
Reduction Reactions: Picolinamide can be reduced to produce various derivatives, including the corresponding amine or dihydropyridine compounds. Reduction can be achieved using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen gas in the presence of a catalyst.
Oxidation Reactions: Picolinamide can be oxidized to produce various derivatives, including the corresponding carboxylic acid or N-oxide compounds. Oxidation can be achieved using oxidizing agents such as potassium permanganate (KMnO4) or chromium trioxide (CrO3).
Complexation Reactions: Picolinamide can form complexes with metal ions due to the presence of the nitrogen atom in the pyridine ring and the oxygen atom in the amide group. These complexes can have various applications in coordination chemistry and catalysis.
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tert-Butyl (2-carbamoylpyridin-3-yl)carbamate
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