Home Chemistry Heterocyclic Building Blocks Pyrrolines 3,4-Dihydro-2H-Pyrrole
Aldol Condensation: 3,4-dihydro-2H-pyrrole can undergo aldol condensation reactions with carbonyl compounds, such as aldehydes and ketones, in the presence of a base. This can lead to the formation of β-enaminones or β-enaminoesters.
Nucleophilic Addition: The nitrogen atom in the pyrrole ring is nucleophilic and can react with electrophiles. For example, it can react with alkyl halides to form N-alkylpyrroles.
Ring Opening Reactions: The pyrrole ring can undergo ring-opening reactions under certain conditions. For instance, it can react with strong acids to open the ring and form substituted amine compounds.
Oxidation: 3,4-dihydro-2H-pyrrole can be oxidized to form pyrrole, a five-membered aromatic ring, under oxidative conditions.
Reduction: It can also be reduced back to piperidine, a six-membered ring compound, by catalytic hydrogenation.
Heterocyclization Reactions: 3,4-dihydro-2H-pyrrole can participate in various heterocyclization reactions to form fused ring systems or other heterocyclic compounds.
Substitution Reactions: Depending on the reaction conditions and substituents on the pyrrole ring, various substitution reactions can occur, including nucleophilic aromatic substitution.
Polymerization: In certain conditions, multiple units of 3,4-dihydro-2H-pyrrole can polymerize to form polymeric materials with interesting properties.
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5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline N-oxide
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