Home Chemistry Organic Building Blocks Fluorinated Building Blocks 4-Fluorobenzamide
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—C(O)NH2).
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Hofmann Rearrangement: Benzamide can undergo Hofmann rearrangement when treated with chlorine or bromine in the presence of a strong base, resulting in the conversion of the amide group to an 【isocyanate|https://www.ambeed.com/isocyanates-and-isothiocyanates.html】 group. Further hydrolysis of the isocyanate can yield an amine with one fewer carbon atom.
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