Home Chemistry Heterocyclic Building Blocks Thiomorpholines Thiomorpholine
Nucleophilic Substitution: Thiomorpholine can undergo nucleophilic substitution reactions, where a nucleophile attacks the sulfur atom, leading to the displacement of a leaving group. For example, thiomorpholine can react with alkyl halides to form alkyl thiomorpholines.
Oxidation: Thiomorpholine can be oxidized using strong oxidizing agents to form sulfoxides or sulfones. This typically involves the oxidation of the sulfur atom within the ring.
Acylation: Thiomorpholine can be acylated with acyl halides or anhydrides to introduce acyl groups to the nitrogen atom or sulfur atom within the ring.
Ring Opening Reactions: Thiomorpholine can undergo ring-opening reactions under certain conditions, resulting in the formation of compounds with an open chain structure.
Reduction: Thiomorpholine can be reduced to its corresponding thiol derivative using reducing agents.
Alkylation: Thiomorpholine can be alkylated with alkyl halides or other alkylating agents to introduce alkyl groups onto the nitrogen or sulfur atoms.
Metal-Catalyzed Reactions: Thiomorpholine can participate in various metal-catalyzed reactions, such as palladium-catalyzed cross-coupling reactions, which can be used to form C-S bonds.
Condensation Reactions: Thiomorpholine can participate in condensation reactions with carbonyl compounds to form various types of products, such as imines and enamines.
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Thiomorpholine-2-carboxylic acid hydrochloride
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4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid
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Thiomorpholine-3-carboxylic acid hydrochloride
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tert-Butyl thiomorpholine-4-carboxylate
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Potassium trifluoro(thiomorpholinomethyl)borate
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Ethyl N-Boc-2-thiomorpholinecarboxylate
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