The ErbB family consists of receptor tyrosine kinases, including ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). Located on the cell membrane, these receptors activate downstream signaling pathways by binding to growth factors, regulating cell growth, division, and survival. Members of the ErbB family are expressed in various cell types and tissues, but are often overexpressed or mutated in cancer cells, leading to excessive signal activation. The specificity of gene expression and mutations are associated with various human diseases, particularly various forms of cancer.