Home Chemistry Heterocyclic Building Blocks Pyridines Methyl 3-Chloropicolinate
Nucleophilic substitution: The chlorine atom can be replaced by a nucleophile, such as an alcohol or amine, to form a new compound.
Ester hydrolysis: Under acidic or basic conditions, the ester bond in methyl 3-chloropicolinate can undergo hydrolysis to produce the corresponding carboxylic acid and alcohol.
Friedel-Crafts acylation: Methyl 3-chloropicolinate can undergo acylation reactions with acid chlorides or acid anhydrides in the presence of Lewis acids like aluminum chloride to form acylated products.
Reduction: The carbonyl group in methyl 3-chloropicolinate can be reduced to a primary alcohol using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: The alcohol moiety in methyl 3-chloropicolinate can be oxidized to the corresponding carboxylic acid using oxidizing agents such as chromic acid (CrO3/H2SO4), potassium permanganate (KMnO4), or Jones reagent (CrO3/H2SO4).
Substitution reactions: The methyl group or the picolinate ring may undergo substitution reactions with appropriate reagents under suitable conditions.
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Dimethyl 3-chloropyridine-2,5-dicarboxylate
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Methyl 3-chloro-5-(methylamino)picolinate
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Methyl 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylate
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