Liver Receptor Homolog-1 (LRH-1) is a member of the nuclear receptor family, existing as a ligand-dependent transcription factor, predominantly expressed in the liver, intestines, pancreas, and ovaries. LRH-1 plays a crucial role in regulating cholesterol metabolism, bile acid synthesis, and the production of steroid hormone precursors. By binding to specific DNA sequences, LRH-1 activates or inhibits the expression of target genes, affecting various physiological processes including cholesterol homeostasis, glucose metabolism, and reproductive functions. The expression regulation and functional mutations of LRH-1 are closely associated with metabolic diseases, cancer development, and reproductive health, making it a potential therapeutic target that is being extensively studied.