Chiral Phosphoric Acids

A623140791616-63-2

(11bR)-4-Hydroxy-2,6-bis(2,4,6-triisopropylphenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide

A1324845874948-63-7

(11bS)-4-Hydroxy-2,6-bis(2,4,6-triisopropylphenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide

A11478781359764-39-8

(R)-4-Hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide

A11478791309446-14-7

(S)-4-Hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide

A1326423226393-33-5

(2R,5R)-1-Hydroxy-2,5-diphenylphospholane 1-oxide

A1326304474049-73-5

(2S,5S)-1-Hydroxy-2,5-diphenylphospholane 1-oxide

Technical Notes:

1.Merging chiral phosphoric acid (CPA) catalysis with NaI/PPh3 photoredox catalysis for enantioselective Minisci-type α-aminoalkylation.

2.Catalyst for redox deracemization of tertiary stereocenter adjacent to perfluoroalkyl and polyfluoroalkyl group.

3.Catalyst for kinetic resolution of tertiary 2-alkoxycarboxamido-allylic alcohols.

4.Chiral phosphoric acid-catalyzed pseudotransannular desymmetrization for enantioselective synthesis of tropanes.

5.Catalyst for enantioselective Friedel− Crafts alkylation of indoles.

6.Catalyst for enantioselective synthesis of atropisomers.

Merging chiral phosphoric acid (CPA) catalysis with NaI/PPh3 photoredox catalysis for enantioselective Minisci-type α-aminoalkylation.[1]

Catalyst for redox deracemization of tertiary stereocenter adjacent to perfluoroalkyl and polyfluoroalkyl group.[2]

Catalyst for kinetic resolution of tertiary 2-alkoxycarboxamido-allylic alcohols.[3]

Chiral phosphoric acid-catalyzed pseudotransannular desymmetrization for enantioselective synthesis of tropanes.[4]

Catalyst for enantioselective Friedel− Crafts alkylation of indoles.[[5]

Catalyst for enantioselective synthesis of atropisomers.[6]

Reference： [1] Science, 2019, 363, 1429. [2] ACS Catal., 2020, 10, 7785. [3] Angew. Chem. Int. Ed., 2019, 58, 10315. [4] Angew. Chem. Int. Ed., 2020, 59, 6780. [5] Org. Lett., 2017, 19, 3426. [6] J. Am. Chem. Soc., 2019, 141, 6698.