Home Chemistry Heterocyclic Building Blocks Pyridines 3-Iodopyridin-4-Ol
Substitution reactions: The iodine atom can undergo substitution reactions with various nucleophiles such as amines, thiols, or organometallic reagents to yield substituted products.
Oxidation reactions: The hydroxyl group can undergo oxidation to yield various products depending on the oxidizing agent used. For example, it can be oxidized to the corresponding ketone or carboxylic acid.
Esterification reactions: The hydroxyl group can react with carboxylic acids or acyl chlorides in the presence of an acid catalyst to form esters.
Reduction reactions: The iodine atom or the hydroxyl group can undergo reduction reactions to yield corresponding products. For instance, the iodine atom can be reduced to iodide, while the hydroxyl group can be reduced to an alkyl group or a hydrogen atom.
Metal-mediated reactions: The compound can undergo various reactions in the presence of metal catalysts or reagents. For example, it can undergo metal-catalyzed cross-coupling reactions to form biaryl compounds.
Nucleophilic aromatic substitution: The pyridine ring can undergo nucleophilic aromatic substitution reactions at the 4-position with suitable nucleophiles, leading to substituted pyridine derivatives.
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2-(Difluoromethyl)-5-iodo-4-hydroxypyridine
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4-Hydroxy-5-iodo-2-(trifluoromethyl)pyridine
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