Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1,3-Difluoro-2-Methylbenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CH3).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Sulfonation: Toluene can be sulfonated, leading to the introduction of a sulfonic acid group (-SO3H) onto the benzene ring. This is often carried out using concentrated sulfuric acid.
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3,5-Difluoro-4-methylphenylboronic acid
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1-Bromo-2,4,5-trifluoro-3-methylbenzene
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(2,4-Difluoro-3-methylphenyl)boronic acid
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