Home Chemistry Organic Building Blocks Bromides 2-Bromo-1-Chloro-4-Fluorobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—Cl,—F).
Suzuki-Miyaura Coupling: Bromobenzene can participate in cross-coupling reactions with organoboron compounds in the presence of a palladium catalyst, resulting in the formation of biaryl compounds.
Reduction: Chlorobenzene can be reduced to form cyclohexane under certain conditions, often using strong reducing agents like sodium in the presence of 【alcohol|https://www.ambeed.com/alcohols.html】.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
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4-Bromo-5-chloro-2-fluorobenzene-1-sulfonyl chloride
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1-Bromo-2-chloro-5-fluoro-4-nitrobenzene
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