Ephrin receptors are a crucial class of cell surface receptors that participate in various biological activities upon binding with Ephrin ligands. They regulate cell adhesion, migration, and intercellular interactions through receptor tyrosine kinase activity. Ephrin receptor signaling involves phosphorylation of tyrosine residues and modulation of cell proliferation and growth via signaling pathways such as Ras-MAPK and PI3K-Akt. These receptors play critical roles in neurodevelopment, angiogenesis, and immune response. Dysregulation of Ephrin receptors is associated with various diseases including cancer and neurodegenerative disorders. Therefore, Ephrin receptors and their ligands are of significant importance in cell biology and pathophysiology.