Home Chemistry Heterocyclic Building Blocks Indazoles 3-Chloro-1H-Indazole
Nucleophilic Substitution: The chlorine atom can undergo nucleophilic substitution reactions with various nucleophiles, leading to the formation of substituted products.
Grignard Reaction: The chlorine atom can be replaced by a Grignard reagent to introduce various functional groups.
Metalation: The 3-position of the indazole ring can be metalated using strong bases such as butyllithium or sodium amide, allowing for further functionalization.
Reduction: The chlorine atom can be reduced to a hydrogen atom using reducing agents such as lithium aluminum hydride or hydrogen gas over a metal catalyst.
Transition Metal Catalyzed Cross-Coupling Reactions: The 3-chloro-1H-indazole can undergo cross-coupling reactions with various organometallic reagents in the presence of transition metal catalysts, such as palladium or copper.
Substitution Reactions: The chlorine atom can be substituted by various functional groups, such as alkyl, aryl, or heteroaryl groups, through nucleophilic aromatic substitution or electrophilic aromatic substitution reactions.
Halogenation: The indazole ring can be further halogenated at other positions using halogenating agents under appropriate conditions.
Ring Closure Reactions: The 3-chloro-1H-indazole can participate in ring closure reactions under specific conditions, leading to the formation of fused or bridged heterocyclic compounds.
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3-Chloro-4-fluoro-1H-indazole-6-carboxylic acid
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Methyl 3-chloro-4-fluoro-1H-indazole-6-carboxylate
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