Home Chemistry Heterocyclic Building Blocks Piperidines Tert-Butyl Piperidin-3-Ylcarbamate
Nucleophilic Substitution: The carbamate group can undergo nucleophilic substitution reactions with various electrophiles, leading to the formation of substituted carbamate derivatives.
Alkylation: The nitrogen atom in the piperidine ring can be alkylated by reaction with alkyl halides or sulfonates.
Acylation: The nitrogen atom in the piperidine ring can undergo acylation reactions to form N-acyl derivatives.
Reduction: The carbonyl group of the carbamate moiety can be reduced to the corresponding alcohols using reducing agents such as lithium aluminum hydride or sodium borohydride.
Dealkylation: The tert-butyl group can be removed under certain conditions, such as treatment with strong acids or nucleophiles, leading to the formation of the corresponding primary amine.
Ring-opening Reactions: The piperidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Esterification: The hydroxyl group of the carbamate can react with carboxylic acids or acid derivatives to form esters through esterification reactions.
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tert-Butyl ((3R,4R)-4-fluoropiperidin-3-yl)carbamate
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tert-Butyl (4,4-difluoropiperidin-3-yl)carbamate
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tert-Butyl ((3S,5R)-5-methylpiperidin-3-yl)carbamate
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(R)-tert-Butyl 3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate
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(S)-tert-Butyl 3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate
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