Home Chemistry Heterocyclic Building Blocks Pyridines 2-Bromo-6-Methoxypyridine
Substitution Reactions: The bromine atom in the 2-position can be substituted by various nucleophiles such as amines, alcohols, thiols, etc., leading to the formation of corresponding substituted products. These substitutions can occur under various conditions such as basic or acidic conditions, or with the use of transition metal catalysts.
Cross-Coupling Reactions: 2-bromo-6-methoxypyridine can participate in cross-coupling reactions, such as Suzuki-Miyaura coupling, Stille coupling, Heck reaction, etc., where the bromine atom acts as a leaving group and couples with an appropriate partner molecule containing suitable functional groups.
Nucleophilic Aromatic Substitution: The pyridine ring can undergo nucleophilic aromatic substitution (SNAr) reactions where the nucleophile substitutes a substituent attached to the pyridine ring. The methoxy group can be substituted under appropriate conditions.
Metalation Reactions: The pyridine ring can be metalated at various positions, particularly at the 6-position adjacent to the methoxy group, by treatment with strong bases or organometallic reagents.
Functional Group Transformations: The methoxy group can be subjected to various transformations such as ether cleavage, oxidation, reduction, and functional group interconversion reactions to introduce or modify other functional groups in the molecule.
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(6-Bromo-2-methoxypyridin-3-yl)methanol
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6-Bromo-3-(bromomethyl)-2-methoxypyridine
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(6-Bromo-2-methoxypyridin-3-yl)methanamine dihydrochloride
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6-Bromo-2-methoxypyridine-3-boronic acid
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