Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1,4-Difluoro-2-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—NO2).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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1-Bromo-2,3,4,5-tetrafluoro-6-nitrobenzene
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(2,5-Difluoro-3-nitrophenyl)methanamine
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