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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 105650-23-5 Chemical Structure| 105650-23-5

Structure of PhIP
CAS No.: 105650-23-5

Chemical Structure| 105650-23-5

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PhIP is a heterocyclic aromatic amine (HAA) derived from cooked meat, belonging to the pyridine class of heterocyclic amines. It is a class 2B carcinogen with estrogenic activity and can form DNA adducts, promoting cancer development。

Synonyms: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

4.5 *For Research Use Only !

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Product Citations

Product Citations

Boyao Zhang ; George-Eugen Maftei ; Bartosz Bartmanski ; Michael Zimmermann ;

Abstract: Organic carcinogens, in particular DNA-reactive compounds, contribute to the irreversible initiation step of tumorigenesis through introduction of genomic instability. Although carcinogen bioactivation and detoxification by human enzymes has been extensively studied, carcinogen biotransformation by human-associated bacteria, the microbiota, has not yet been systematically investigated. We tested the biotransformation of 68 mutagenic carcinogens by 34 bacterial species representative for the upper and lower human gastrointestinal tract and found that the majority (41) of the tested carcinogens undergo bacterial biotransformation. To assess the functional consequences of microbial carcinogen metabolism, we developed a pipeline to couple gut bacterial carcinogen biotransformation assays with Ames mutagenicity testing and liver biotransformation experiments. This revealed a bidirectional crosstalk between gut microbiota and host carcinogen metabolism, which we validated in gnotobiotic mouse models. Overall, the systematic assessment of gut microbiota carcinogen biotransformation and its interplay with host metabolism highlights the gut microbiome as an important modulator of exposome-induced tumorigenesis.

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Product Details of PhIP

CAS No. :105650-23-5
Formula : C13H12N4
M.W : 224.26
SMILES Code : CN1C(N)=NC2=NC=C(C3=CC=CC=C3)C=C21
Synonyms :
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
MDL No. :MFCD00210745

Safety of PhIP

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302+H312-H315-H319-H331-H335-H350-H360
Precautionary Statements:P261-P280-P305+P351+P338-P311
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.46mL

0.89mL

0.45mL

22.30mL

4.46mL

2.23mL

44.59mL

8.92mL

4.46mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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