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Chemical Structure| 137-17-7 Chemical Structure| 137-17-7

Structure of 137-17-7

Chemical Structure| 137-17-7

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Product Citations

Product Citations

Boyao Zhang ; George-Eugen Maftei ; Bartosz Bartmanski ; Michael Zimmermann ;

Abstract: Organic carcinogens, in particular DNA-reactive compounds, contribute to the irreversible initiation step of tumorigenesis through introduction of genomic instability. Although carcinogen bioactivation and detoxification by human enzymes has been extensively studied, carcinogen biotransformation by human-associated bacteria, the microbiota, has not yet been systematically investigated. We tested the biotransformation of 68 mutagenic carcinogens by 34 bacterial species representative for the upper and lower human gastrointestinal tract and found that the majority (41) of the tested carcinogens undergo bacterial biotransformation. To assess the functional consequences of microbial carcinogen metabolism, we developed a pipeline to couple gut bacterial carcinogen biotransformation assays with Ames mutagenicity testing and liver biotransformation experiments. This revealed a bidirectional crosstalk between gut microbiota and host carcinogen metabolism, which we validated in gnotobiotic mouse models. Overall, the systematic assessment of gut microbiota carcinogen biotransformation and its interplay with host metabolism highlights the gut microbiome as an important modulator of exposome-induced tumorigenesis.

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Product Details of [ 137-17-7 ]

CAS No. :137-17-7
Formula : C9H13N
M.W : 135.21
SMILES Code : NC1=CC(C)=C(C)C=C1C
MDL No. :MFCD00025201
InChI Key :BMIPMKQAAJKBKP-UHFFFAOYSA-N
Pubchem ID :8717

Safety of [ 137-17-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H373-H301+H311+H331
Precautionary Statements:P262-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P311-P330-P361-P363-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 137-17-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 137-17-7 ]

[ 137-17-7 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 6092-47-3 ]
  • [ 137-17-7 ]
  • [<i>N</i>-(2,4,5-trimethyl-phenyl)-glycyl]-carbamic acid ethyl ester [ No CAS ]
  • 2
  • [ 632-80-4 ]
  • [ 137-17-7 ]
  • [ 101439-62-7 ]
  • 3
  • [ 610-91-3 ]
  • [ 137-17-7 ]
YieldReaction ConditionsOperation in experiment
palladium; In methanol; a. 2,4,5-Trimethylphenylamine A solution of <strong>[610-91-3]5-nitropseudocumene</strong> (400 mg, 2.42 mmol) in methanol (30 ml) was hydrogenated over palladium (5 wt % on activated carbon) at 50 psi for 3 h. The mixture was filtered through Celite. The filtrate was rotary evaporated to leave a light purple residue (246 mg, 75%). 1H NMR (CDCl3): 6.82 (s, 1H), 6.50 (s, 1H), 3.42 (s, 2H), 2.16 (s, 3H), 2.14 (s, 3H), 2.11 (s, 3H).
With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 35℃; for 2.0h; 10 in a solution of <strong>[610-91-3]5-nitropseudocumene</strong> (2.00 g) in ethyl acetate (60.5 mL)% Palladium on carbon (56.5 wt% water content, 920 mg) is added and the mixture is hydrogenated.Below, the mixture was stirred at 35 C. for 2 hours. Filter the reaction mixture through a Celite paddid. The filtrate was concentrated under reduced pressure to give the title compound (1.62 g).
  • 4
  • [ 137-17-7 ]
  • [ 5469-19-2 ]
  • 5
  • [ 137-17-7 ]
  • [ 610-91-3 ]
 

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