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Chemical Structure| 53-96-3 Chemical Structure| 53-96-3

Structure of 2-Acetamidofluorene
CAS No.: 53-96-3

Chemical Structure| 53-96-3

2-Acetamidofluorene

CAS No.: 53-96-3

2-Acetamidofluorene is a carcinogen widely used to induce liver cancer in animal models for cancer research.

Synonyms: 2-AAF; N-2-Fluorenylacetamide; 2AAF, 2-AA-F, 2A-AF, 2-Acetylaminofluorene

4.5 *For Research Use Only !

Cat. No.: A534089 Purity: 99+%

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Product Citations

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Boyao Zhang ; George-Eugen Maftei ; Bartosz Bartmanski ; Michael Zimmermann ;

Abstract: Organic carcinogens, in particular DNA-reactive compounds, contribute to the irreversible initiation step of tumorigenesis through introduction of genomic instability. Although carcinogen bioactivation and detoxification by human enzymes has been extensively studied, carcinogen biotransformation by human-associated bacteria, the microbiota, has not yet been systematically investigated. We tested the biotransformation of 68 mutagenic carcinogens by 34 bacterial species representative for the upper and lower human gastrointestinal tract and found that the majority (41) of the tested carcinogens undergo bacterial biotransformation. To assess the functional consequences of microbial carcinogen metabolism, we developed a pipeline to couple gut bacterial carcinogen biotransformation assays with Ames mutagenicity testing and liver biotransformation experiments. This revealed a bidirectional crosstalk between gut microbiota and host carcinogen metabolism, which we validated in gnotobiotic mouse models. Overall, the systematic assessment of gut microbiota carcinogen biotransformation and its interplay with host metabolism highlights the gut microbiome as an important modulator of exposome-induced tumorigenesis.

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Product Details of 2-Acetamidofluorene

CAS No. :53-96-3
Formula : C15H13NO
M.W : 223.27
SMILES Code : CC(NC1=CC(CC2=C3C=CC=C2)=C3C=C1)=O
Synonyms :
2-AAF; N-2-Fluorenylacetamide; 2AAF, 2-AA-F, 2A-AF, 2-Acetylaminofluorene
MDL No. :MFCD00001116
InChI Key :CZIHNRWJTSTCEX-UHFFFAOYSA-N
Pubchem ID :5897

Safety of 2-Acetamidofluorene

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H351
Precautionary Statements:P201-P202-P264-P270-P280-P308+P313-P301+P312+P330-P405-P501

Isoform Comparison

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4.48mL

0.90mL

0.45mL

22.39mL

4.48mL

2.24mL

44.79mL

8.96mL

4.48mL

 

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