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[ CAS No. 99-59-2 ] {[proInfo.proName]}

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Chemical Structure| 99-59-2
Chemical Structure| 99-59-2
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Product Details of [ 99-59-2 ]

CAS No. :99-59-2 MDL No. :MFCD00007261
Formula : C7H8N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :NIPDVSLAMPAWTP-UHFFFAOYSA-N
M.W : 168.15 Pubchem ID :7447
Synonyms :

Safety of [ 99-59-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335-H351-H361 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 99-59-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 99-59-2 ]
  • Downstream synthetic route of [ 99-59-2 ]

[ 99-59-2 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 100-17-4 ]
  • [ 104-94-9 ]
  • [ 99-57-0 ]
  • [ 99-59-2 ]
Reference: [1] Organic Letters, 2006, vol. 8, # 7, p. 1451 - 1454
  • 2
  • [ 99-59-2 ]
  • [ 19056-41-8 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980, p. 832 - 834
  • 3
  • [ 99-59-2 ]
  • [ 455-93-6 ]
Reference: [1] Journal of Fluorine Chemistry, 1999, vol. 97, # 1-2, p. 127 - 133
  • 4
  • [ 99-59-2 ]
  • [ 4920-79-0 ]
Reference: [1] Chem. Zentralbl., 1901, vol. 72, # I, p. 739
[2] Journal of the Chemical Society, 1867, vol. 20, p. 94[3] Journal fuer Praktische Chemie (Leipzig), 1867, vol. <1> 101, p. 91
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980, p. 832 - 834
  • 5
  • [ 119-27-7 ]
  • [ 577-72-0 ]
  • [ 99-59-2 ]
Reference: [1] Tetrahedron Letters, 1994, vol. 35, # 42, p. 7867 - 7870
[2] Recueil des Travaux Chimiques des Pays-Bas, 1946, vol. 65, p. 346,350, 357
[3] Tetrahedron Letters, 1997, vol. 38, # 17, p. 3043 - 3046
[4] Russian Journal of General Chemistry, 2006, vol. 76, # 1, p. 76 - 81
  • 6
  • [ 119-27-7 ]
  • [ 121-44-8 ]
  • [ 13027-36-6 ]
  • [ 577-72-0 ]
  • [ 99-59-2 ]
Reference: [1] Tetrahedron, 1987, vol. 43, # 2, p. 351 - 360
  • 7
  • [ 99-59-2 ]
  • [ 5399-03-1 ]
YieldReaction ConditionsOperation in experiment
75%
Stage #1: With sulfuric acid; sodium nitrite In water at 5℃;
Stage #2: With potassium iodide In water at 90℃; for 1 h;
Step A. 2-Iodo-1-methoxy-4-nitrobenzene 2-Methoxy-5-nitroaniline (10.0 g, 0.060 mol) was stirred in water (150 mL) and concentrated (conc.) sulfuric acid (12 mL, 0.22 mol). The solution was cooled below 5° C. with an ice-salt bath, and a solution of sodium nitrite (4.8 g, 0.070 mol) in water (40 mL) was added dropwise while maintaining the temperature below 5° C. A solution of potassium iodide (16.8 g, 0.101 mol) was added and the mixture was heated to 90° C. for 1 hour. Cooling to 0° C. gave dark red crystals which were filtered, washed with water, and dried. Purification by silica gel chromatography using ethyl acetate/hexanes gave the desired compound (13.6 g, 75percent). 1H NMR (300 MHz, DMSO-d6): δ 8.57 (s, 1H), 8.28 (d, 1H), 7.19 (d, 1H), 3.98 (s, 3H). LCMS for C7H7INO3 (M+H)+: m/z=280.1.
Reference: [1] Canadian Journal of Chemistry, 2005, vol. 83, # 3, p. 213 - 219
[2] Patent: US2009/286778, 2009, A1, . Location in patent: Page/Page column 79
[3] Chem. News J. Ind. Sci., 1901, vol. 83, p. 285[4] Journal of the Chemical Society, 1901, vol. 79, p. 1076,1077
[5] P. Ch. S., p. 238[6] Chem. Zentralbl., 1901, vol. 72, # II, p. 97
[7] Journal of the American Chemical Society, 1984, vol. 106, # 15, p. 4218 - 4227
  • 8
  • [ 99-59-2 ]
  • [ 5197-28-4 ]
Reference: [1] Journal of the Chemical Society, 1867, vol. 20, p. 94[2] Journal fuer Praktische Chemie (Leipzig), 1867, vol. <1> 101, p. 91
[3] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980, p. 832 - 834
[4] Canadian Journal of Chemistry, 2005, vol. 83, # 3, p. 213 - 219
  • 9
  • [ 99-59-2 ]
  • [ 107575-60-0 ]
Reference: [1] Patent: CN104557921, 2018, B,
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