Structure of 16582-58-4
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CAS No. : | 16582-58-4 |
Formula : | C7H5IN2S |
M.W : | 276.10 |
SMILES Code : | NC1=NC2=CC=C(I)C=C2S1 |
MDL No. : | MFCD00996639 |
InChI Key : | WMKLSFIAHMBOTP-UHFFFAOYSA-N |
Pubchem ID : | 3524848 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 11 |
Num. arom. heavy atoms | 9 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 1.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 56.74 |
TPSA ? Topological Polar Surface Area: Calculated from | 67.15 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 1.93 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 2.68 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 2.49 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | 2.17 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 3.39 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 2.53 |
Log S (ESOL):? ESOL: Topological method implemented from | -3.85 |
Solubility | 0.0394 mg/ml ; 0.000143 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (Ali)? Ali: Topological method implemented from | -3.74 |
Solubility | 0.05 mg/ml ; 0.000181 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -3.56 |
Solubility | 0.076 mg/ml ; 0.000275 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | Yes |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -6.08 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<0.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 2.35 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | Stage #1: at 20℃; Cooling with ice Stage #2: With ammonium hydroxide In water | General procedure: A mixture of 0.1 mol of 4-substituted aniline and 0.1 mol of Potassium thiocyanate (KCNS) in 100 ml glacial acetic acid (AcOH) was cooled in an ice bath and stirred for 10-20 min, and then 0.1 mol bromine in glacial acetic acid was added dropwise at such a rate to keep the temperature below 10 °C throughout the addition. The reaction mixture was stirred at room temperature for 2-4 h, the hydrobromide (HBr) salt thus separated out was filtered, washed with acetic acid, dried, dissolved in hot water and basified to pH 11.0 with ammonia solution (NH4OH) and the resulting precipitate was filtered, washed with water and dried to get the desired product 3a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene: acetone (8:2) solvent system. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With bromine In chloroform for 6 h; Reflux | (0143) Chloroform suspension (7 ml) of 1-(4-iodophenyl)thiourea (889 mg, 3.19 mmol) was added with bromine (328 μl, 6.40 mmol), and heated to reflux and stirred for 6 hours. After the reaction was completed and the solvent was removed, the residue was added with dichloromethane and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. After the solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure, the resulting deposits were filtered to obtain 650 mg 2-amino-6-iodobenzothiazole in a yield of 73percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With bromine; In chloroform; for 6h;Reflux; | (0143) Chloroform suspension (7 ml) of 1-(4-iodophenyl)thiourea (889 mg, 3.19 mmol) was added with bromine (328 mul, 6.40 mmol), and heated to reflux and stirred for 6 hours. After the reaction was completed and the solvent was removed, the residue was added with dichloromethane and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. After the solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure, the resulting deposits were filtered to obtain 650 mg 2-amino-6-iodobenzothiazole in a yield of 73%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Listed below are some typical examples of said 2-aminobenzothiazole compounds: ... 2-amino-6-methoxybenzothiazole 2-amino-6-ethoxybenzothiazole 2-amino-6-chlorobenzothiazole 2-amino-6-bromobenzothiazole 2-amino-6-iodobenzothiazole 2-amino-6-cyanobenzothiazole 2-amino-6-thiocyanobenzothiazole 2-amino-6-methylbenzothiazole ... |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With potassium carbonate; In benzene;Reflux; | General procedure: Chloroacetyl chloride (0.06 mol) was added dropwise to a mixture of the appropriate 2-amino-6-Substituted benzothiazole, 3a-k (0.05 mol) and K2CO3 (0.06 mol) in benzene (50 mL) at room temperature. The reaction mixture was refluxed for 6-12 h, then, after cooling to room temperature, it was slowly poured into 100 mL of ice water. A solid was formed thereafter. The precipitate was separated by filtration and washed successively with water. The product was dried under vacuum to obtain 4a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene: acetone (8:2) solvent system. |
With potassium carbonate; In benzene;Reflux; | General procedure: Chloroacetyl chloride (0.06mol) was added dropwise to a mixture of the appropriate 2-amino-6-substituted benzothiazoles, 2a-k (0.05mol) and K2CO3 (0.06mol) in benzene (50mL) at room temperature. The reaction mixture was refluxed for 6-12h, then, after cooling to room temperature, it was slowly poured into 100mL of ice water. A solid was formed thereafter. The precipitate was separated by filtration and washed successively with water. The product was dried under vacuum to obtain 3a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene:acetone (8:2) solvent system. | |
With potassium carbonate; In benzene;Reflux; | General procedure: To 0.05 mol of each 2-amino-6-substituted benzothiazole derivative (3a-k) and 0.06 mol of anhydrous K2CO3 in 50 mL of benzene, 0.06 mol of chloroacetyl chloride (0.06 mol) was added dropwise at room temperature and mixture was allowed to reflux for 6 to 12 h. The reaction progress was monitored by TLC using toluene : acetone (V/V, 8:2) solvent system. After the completion of the reaction, the mixture was cooled and poured into crushed ice. A solid thus obtained was filtered, washed with water and dried on vacuum oven to get 4a-k [27]. |
With potassium carbonate; In benzene; at 20℃;Reflux; | General procedure: Chloroacetyl chloride (0.06 mol) was added dropwise to a mixture of the appropriate 2-amino-6-substituted benzothiazole, 3a-k (0.05 mol)and K2CO3 (0.06 mol) in benzene (50 mL) at room temperature. The reaction mixture was refluxed for 6 to 12 h, then, after cooling to room temperature, it was slowly poured into ice water (100 mL). The solid that formed was separated by filtration, washed successively with water, then dried under vacuum to obtain 4a-k.17-20 The progress of the reaction was monitored by TLC using toluene: acetone (8 : 2) solvent system. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | General procedure: A mixture of 0.1 mol of 4-substituted aniline and 0.1 mol of Potassium thiocyanate (KCNS) in 100 ml glacial acetic acid (AcOH) was cooled in an ice bath and stirred for 10-20 min, and then 0.1 mol bromine in glacial acetic acid was added dropwise at such a rate to keep the temperature below 10 C throughout the addition. The reaction mixture was stirred at room temperature for 2-4 h, the hydrobromide (HBr) salt thus separated out was filtered, washed with acetic acid, dried, dissolved in hot water and basified to pH 11.0 with ammonia solution (NH4OH) and the resulting precipitate was filtered, washed with water and dried to get the desired product 3a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene: acetone (8:2) solvent system. | |
General procedure: A mixture of 0.1mol of appropriate 4-substituted amines and 0.1mol of Potassium thiocyanate (KCNS) in 100mL glacial acetic acid (AcOH) were cooled in an ice bath and stirred for 10-20min, and then 0.1mol bromine in glacial acetic acid was added dropwise at such a rate to keep the temperature below 10C throughout the addition. The reaction mixture was stirred at room temperature for 2-4h, the hydrobromide (HBr) salt thus separated out was filtered, washed with acetic acid, dried, dissolved in hot water and basified to pH 11.0 with ammonia solution (NH4OH) and the resulting precipitate was filtered, washed with water and dried to get the desired product 2a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene:acetone (8:2) solvent system. | ||
General procedure: To 100 mL glacial acetic acid, 0.1 mol of appropriate para-substituted amine derivative and equimolecular amount of potassium thiocyanate was added and reaction mixture was kept in an ice bath and cooled. The mixture was allowed to cool at this temperature up to 20 min. Then, in the reaction mixture, bromine in glacial acetic acid (0.1 mol) was added very slowly to maintain the temperature of the reaction mixture below 10 C and was stirred at room temperature for 2 to 4 h to obtain the hydrobromide (HBr) salt. The salt was then filtered, washed with acetic acid, dried on vacuum oven and basified to pH 11.0 with NH3·H2O. The solid precipitate thus formed was filtered, washed with water and dried on vacuum oven to yield the intermediates 3a-k. TLC technique involving toluene : acetone (V/V, 8:2) solvent system was used to monitor the reaction progress [26]. |
With bromine; In acetic acid;Cooling with ice; | General procedure: A mixture of 0.1 mol of 4-substituted aniline and 0.1 mol ofPotassium thiocyanate (KCNS) in 100 ml glacial acetic acid (AcOH) was cooled inan ice bath and stirred for 10 to 20 min, and then 0.1 mol bromine in glacialacetic acid was added dropwise at such a rate to keep the temperature below 10C throughout the addition. Theprogress of the reaction was monitored by Thin Layer Chromatography usingtoluene: acetone (8:2) solvent system. The reaction mixture was stirredat room temperature for 2 to 4 hrs, the hydrobromide (HBr) salt thus separatedout was filtered, washed with acetic acid, dried, dissolved in hot water and basified to pH 11.0 with ammonia solution (NH4OH)and the resulting precipitate was filtered, washed with water and dried to getthe desired product 2a-q. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonium hydroxide; In water; | General procedure: A mixture of 4-substituted aniline (0.1 mol) and potassium thiocyanate (0.1 mol) in glacial acetic acid (100 mL) was cooled in an ice bath and stirred for 10 to 20 min, and then bromine (0.1 mol) in glacial acetic acid was added dropwise at such a rate as to keep the temperature below 10 C throughout the addition. The reaction mixture was stirred at room temperature for 2-4 h, and the hydrobromide salt that separated out was filtered, washed with acetic acid, dried, dissolved in hot water and basified to pH 11.0 with ammonia solution. The resulting precipitate was filtered, washed with water and dried to give the products 3a-k.13-16 The progress of the reaction was monitored by TLC using toluene: acetone (8 : 2) solvent system. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | In acetonitrile;Reflux; | General procedure: In a flask charged with 50 mL of CH3CN was added2.5 mmol of compound 5 andappropriate benzothiazole derivatives (2a-r,1.5 eq.) and the reaction mixture was refluxed for 10-38 h until the completeconsumption of starting material as detected by TLC.After the completion of the reaction, the reactionmixture was treated with ice and the resulting solid was filtered and washedwith water (2 x 25 mL). The residue was purifiedby a silica gel column chromatography andwas eluted with dichloromethane: methanol (40:1) to afford correspondingproducts 6a-r in 49-82% of yields. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; | N,N-dimethylformamide solution (3 ml) containing <strong>[16582-58-4]2-amino-6-iodobenzothiazole</strong> (200 mg, 0.723 mmol) and 3,4-dimethoxyphenylacetic acid (157 mg, 0.795 mmol) was added with N,N-diisopropylethylamine (139 mul, 0.803 mmol) and 0-(6-chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (360 mg, 0.870 mmol) and stirred over night at room temperature. After completion of the reaction, the solution was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. The solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. The residue was recrystallized with ethanol and 167 mg of 2-(2-(3,4-dimethoxyphenyl)acetamide)-6-iodobenzothiazole was obtained in a yield of 50%. 1H NMR (DMSO-d6): delta 12.61 (s, 1H), 8.37 (s, 1H), 7.73-7.69 (m, 1H), 7.54 (d, J=8.0 Hz, 1H), 6.97-6.84 (m, 3H), 3.75-3.72 (m, 8H). MS (ESI) Found; 455[M+H]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
48% | With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; | N,N-dimethylformamide solution (2 ml) containing <strong>[16582-58-4]2-amino-6-iodobenzothiazole</strong> (100 mg, 0.362 mmol) and 3-(3,4-dimethoxyphenyl)propionic acid (91.4 mg, 0.435 mmol) was added with N,N-diisopropylethylamine (69.4 mul, 0.398 mmol) and O-(6-chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (180 mg, 0.435 mmol) and stirred over night at room temperature. After completion of the reaction, the solution was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. The solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. The residue was recrystallized with ethanol and 83 mg of 2-(3-(3,4-dimethoxyphenyl)propanamide)-6-iodobenzothiazole in a yield of 48%. 1H NMR (DMSO-d6): delta 12.42 (s, 1H), 8.37 (s, 1H), 7.72-7.69 (m, 1H), 7.52 (d, J=8.4 Hz, 1H), 6.85-6.83 (m, 2H), 6.75-6.72 (m, 1H), 3.71 (s, 3H), 3.69 (s, 3H), 2.90-2.76 (m, 4H). MS (ESI) Found; 469[M+H] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30% | With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; | N,N-dimethylformamide solution (3 ml) containing <strong>[16582-58-4]2-amino-6-iodobenzothiazole</strong> (250 mg, 0.905 mmol) and 4-(3,4-dimethoxyphenyl)butanoic acid (224 mg, 0.995 mmol) was added with N,N-diisopropylethylamine (174 mul, 0.995 mmol) and O-(6-chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (450 mg, 1.09 mmol) and stirred over night at room temperature. After completion of the reaction, the solution was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. The solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. The residue was recrystallized with ethanol and 131 mg of 2-(4-(3,4-dimethoxyphenyl)butanamide)-6-iodobenzothiazole was obtained in a yield of 30%. 1H NMR (DMSO-d6): delta 12.37 (s, 1H), 8.37 (s, 1H), 7.72-7.69 (m, 1H), 7.52 (d, J=8.4 Hz, 1H), 6.86-6.79 (m, 2H), 6.70 (d, J=8.0 Hz, 1H), 3.73 (s, 3H), 3.70 (s, 3H), 2.58-2.48 (m, 4H), 1.96-1.86 (m, 2H). MS (ESI) Found; 483[M+H]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; | N,N-dimethylformamide solution (3 ml) containing <strong>[16582-58-4]2-amino-6-iodobenzothiazole</strong> (200 mg, 0.723 mmol) and 3-(3-methoxy-4-propoxyphenyl)propionic acid (200 mg, 0.839 mmol) was added with N,N-diisopropylethylamine (140 mul, 0.803 mmol) and O-(6-chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (360 mg, 0.870 mmol) and stirred over night at room temperature. After completion of the reaction, the solution was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. The solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. The residue was recrystallized with ethanol and 217 mg of 2-(3-(3-methoxy-4-propoxyphenyl)propanamide)-6-iodobenzothiazole was obtained in a yield of 60%. 1H NMR (DMSO-d6): delta 12.42 (s, 1H), 8.38-8.37 (m, 1H), 7.72-7.69 (m, 1H), 7.54-7.51 (m, 1H), 6.85-6.82 (m, 2H), 6.72 (d, J=8.0 Hz, 1H), 3.86-3.82 (m, 2H), 3.72 (s, 3H), 2.87-2.78 (m, 4H), 1.72-1.65 (m, 2H), 094 (t, J=7.3 Hz, 3H). MS (ESI) Found; 497[M+H]+ |
Tags: 16582-58-4 synthesis path| 16582-58-4 SDS| 16582-58-4 COA| 16582-58-4 purity| 16582-58-4 application| 16582-58-4 NMR| 16582-58-4 COA| 16582-58-4 structure
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P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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