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Chemical Structure| 13575-74-1 Chemical Structure| 13575-74-1
Chemical Structure| 13575-74-1

4-(3,4-Dimethoxyphenyl)butanoic acid

CAS No.: 13575-74-1

4.5 *For Research Use Only !

Cat. No.: A875908 Purity: 95%

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Product Details of [ 13575-74-1 ]

CAS No. :13575-74-1
Formula : C12H16O4
M.W : 224.25
SMILES Code : O=C(O)CCCC1=CC=C(OC)C(OC)=C1
MDL No. :MFCD00134101
InChI Key :IDQKCIAJGRMMNC-UHFFFAOYSA-N
Pubchem ID :323675

Safety of [ 13575-74-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 13575-74-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 13575-74-1 ]

[ 13575-74-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 3929-47-3 ]
  • [ 13575-74-1 ]
  • 2
  • [ 13575-74-1 ]
  • [ 16582-58-4 ]
  • 2-(4-(3,4-dimethoxyphenyl)butanamide)-6-iodobenzothiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
30% With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; N,N-dimethylformamide solution (3 ml) containing <strong>[16582-58-4]2-amino-6-iodobenzothiazole</strong> (250 mg, 0.905 mmol) and 4-(3,4-dimethoxyphenyl)butanoic acid (224 mg, 0.995 mmol) was added with N,N-diisopropylethylamine (174 mul, 0.995 mmol) and O-(6-chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (450 mg, 1.09 mmol) and stirred over night at room temperature. After completion of the reaction, the solution was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. The solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. The residue was recrystallized with ethanol and 131 mg of 2-(4-(3,4-dimethoxyphenyl)butanamide)-6-iodobenzothiazole was obtained in a yield of 30%. 1H NMR (DMSO-d6): delta 12.37 (s, 1H), 8.37 (s, 1H), 7.72-7.69 (m, 1H), 7.52 (d, J=8.4 Hz, 1H), 6.86-6.79 (m, 2H), 6.70 (d, J=8.0 Hz, 1H), 3.73 (s, 3H), 3.70 (s, 3H), 2.58-2.48 (m, 4H), 1.96-1.86 (m, 2H). MS (ESI) Found; 483[M+H]+
 

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