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Structure of 333-20-0
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 333-20-0 |
Formula : | CKNS |
M.W : | 97.18 |
SMILES Code : | [S-]C#N.[K+] |
MDL No. : | MFCD00011413 |
InChI Key : | ZNNZYHKDIALBAK-UHFFFAOYSA-M |
Pubchem ID : | 516872 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H302-H312-H332-H318-H401-H412 |
Precautionary Statements: | P261-P264-P270-P271-P273-P280-P301+P312+P330-P302+P352+P310-P304+P340+P312-P305+P351+P338+P310-P501 |
Class: | 8 |
UN#: | 3261 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | Stage #1: at 20℃; Cooling with ice Stage #2: With ammonium hydroxide In water |
General procedure: A mixture of 0.1 mol of 4-substituted aniline and 0.1 mol of Potassium thiocyanate (KCNS) in 100 ml glacial acetic acid (AcOH) was cooled in an ice bath and stirred for 10-20 min, and then 0.1 mol bromine in glacial acetic acid was added dropwise at such a rate to keep the temperature below 10 °C throughout the addition. The reaction mixture was stirred at room temperature for 2-4 h, the hydrobromide (HBr) salt thus separated out was filtered, washed with acetic acid, dried, dissolved in hot water and basified to pH 11.0 with ammonia solution (NH4OH) and the resulting precipitate was filtered, washed with water and dried to get the desired product 3a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene: acetone (8:2) solvent system. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | Stage #1: With nano-BF3/SiO2 In acetonitrile for 0.5 h; Cooling with ice Stage #2: With bromine In acetonitrile at 0 - 20℃; for 5 h; |
General procedure: A solution of substituted aniline (2 mmol) in acetonitrile (15 ml) was added to a solution of KSCN (8 mmol) in acetonitrile (15 ml). Then, 0.06 g (30 mol percent BF3) of nano-BF3/SiO2 was added to the mixture, then was placed in a freezing mixture of ice and salt and mechanically stirred for 30 min. Then, bromine (4 mmol, 0.2 ml) in acetonitrile (3 ml) as solvent was added from a dropping funnel at such a rate that the temperature never rose beyond 0°C. After all the bromine was added at 60 min, the solution was stirred for 4 h at room temperature. The progress of the reaction was monitored by TLC. Then, the mixture was poured into water with stirring and the mixture was heated to 70°C on a steam bath and filtered hot to remove the catalyst and the recovered catalyst was washed with acetone and reused in the reaction. The filtrate was neutralized with 10 percent NaOH solution and the precipitate was collected on a filter, dried and recrystallized from ethanol (10 ml) to afford the corresponding products. All of the 2-aminobenzothiazole products were identified by physical and spectroscopic data as reported below, compared and contrasted with authentic samples.#10;Spectral data for selected products#10;6-Bromo-1,3-benzothiazol-2-amine (2e) Yellow solid; Yield = 93 percent; m.p. =202–204°C; (m.p. = 203°C), FT-IR (KBr)/t(cm-1): 3315, 3012, 2835,1580, 1476, 1261, 920, 742, 512. 1H NMR (400 MHz, CDCl3)/d ppm: 5.44 (s, 2H, NH2) 7.4–7.5 (d, 2H, Ar–H), 7.71 (s, 1H, Ar–H); 13C NMR/(100 MHz, DMSO-d6)/d ppm: 119, 120.9, 125.15, 126.07, 133.1, 152.15, 167.75.#10; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19% | at 0 - 15℃; for 16 h; | j00320j To a mixture of 3,4-dichloroaniline (10 g, 62 mmol) and potassium thiocyanate (48 g, 0.49 mol) in acetic acid (160 mL) at 0 °C was added slowly with constant stirring a solution of liquidbromine (31 g, 0.19 mol) in acetic acid (160 mL). The temperature was maintained at 0 °C throughout the addition. The solution was stirred for 2 hours at 0°C and 14 hours at 15 °C, then diluted with water (100 mL), adjusted to pH 78 with ammonium hydroxide and extracted with ethyl acetate (3 x 50 mL). The combined organic layers were washed with brine (3 x 300 mL) and concentrated in vacuo. The residue was purified by prep-HPLC [Instmment: GX-B; Column: GEMNI 250 x 50 mm, particle size: 10 .im; Mobile phase: 25-50percent acetonitrile in H20 (add 0.1percent TFA, v/v)j to give compound B- 24 (2.6 g, 19percent yield) as a white solid. LCMS (J): tR=0.694 mi (ES) m/z (M+H)219.0. ‘H-NMR (CD3OD, 400 MHz): 7.89 (s, 1H), 7.55 (s, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With bromine; In acetic acid;Cooling with ice; | General procedure: A mixture of 0.1 mol of 4?substituted aniline and 0.1 mol ofPotassium thiocyanate (KCNS) in 100 ml glacial acetic acid (AcOH) was cooled inan ice bath and stirred for 10 to 20 min, and then 0.1 mol bromine in glacialacetic acid was added dropwise at such a rate to keep the temperature below 10C throughout the addition. Theprogress of the reaction was monitored by Thin Layer Chromatography usingtoluene: acetone (8:2) solvent system. The reaction mixture was stirredat room temperature for 2 to 4 hrs, the hydrobromide (HBr) salt thus separatedout was filtered, washed with acetic acid, dried, dissolved in hot water and basified to pH 11.0 with ammonia solution (NH4OH)and the resulting precipitate was filtered, washed with water and dried to getthe desired product 2a-q. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With bromine; In acetic acid; at 25℃; for 12h; | General procedure: An appropriate aniline derivative (1 and 2) (0.04 mol) and KSCN (0.16 mol, 15.5 g) weredissolved in glacial acetic acid (70 mL). A solution of bromine (0.04 mol, 2.05 mL) in glacialacetic acid (10 mL) was added dropwise. The mixture was stirred for 12 h. The solution wasfiltered and neutralized by ammonia (33%). The precipitate was filtered off, dried andrecrystallized from ethanol.1 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | To a solution of <strong>[1903-91-9]2-methoxy-acetamidine hydrochloride</strong> (4.66 g, 0.037 mol) in methanol (20 mL) at 0 C. under vigorous stirring was added dropwise bromine (1.90 mL, 0.037 mol) and a 5.4M sodium methylate solution in methanol (13.7 mL, 0.037 mol) simultaneously over 30 min maintaining a slight bromine excess by color. To the resulting nearly colorless suspension was added dropwise a solution of potassium thiocyanate (3.64 g, 0.037 mol) in methanol (20 mL) over 10 min at 0-10 C. The resulting mixture was stirred for 2 h at 0-10 C. and filtered. The isolated material was washed with methanol and dried which afforded a brown solid which was purified by flash chromatography (silica gel 60, 5% methanol/diethyl ether) and crystallized from diethyl ether/hexanes which afforded 3-methoxymethyl-[1,2,4]thiadiazol-5-ylamine (3.25 g, 60%) as a light yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
43% | Synthetic Example 4; (R)-3-Mercapto-2-(4,5,6,7-tetrahydro-benzothiazoI-2-yIamino)-propionic acid; Step 1 : (RV2-C4.5.6 J-Tetrahvdro-benzothiazol-2-ylaminoV3-tritylsulfanyl- propionic acid; 2-Chloro-cyclohexanone (1.06 g, 8.00 mmol) and potassium thiocyanate (1.04 g, 9.06 mmol) in MeCN (24 mL) are heated at 120 0C for 80 min under microwave conditions. The reaction mixture was filtered and the solvent was removed in vacuum. The resultant residue was dissolved in EtOH (40 mL). S-Trityl- L-cysteine (2.91 g, 8.00 mmol) and triethylamine (1.2 mL, 8.61 mmol) were added. The reaction mixture was stirred at 5O0C for 6.5 h, after which time the solvents were removed in vacuum. The residue was dissolved in CH2Cl2, washed with 0.1N HCl solution, then with brine, dried over anhydrous Na2SO4 and concentrated. The crude product was purified by flash column chromatography using gradient elution from CH2Cl2MeOH (50:1) to CH2Cl2-MeOH (3:1) to give 1.72 g (43percent) of (R)-2-(4,5,6,7- tetrahydro-benzothiazol-2-ylamino)-3 -tritylsulfanyl-propionic acid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | Step 2: (R)-2-('5-Methyl-4-phenyl-thiazol-2-ylamino)-3-tritylsulfanyl-propionic acid; 2-Bromo-l-phenyl-propan-l-one (2.13 g, 10.0 mmol) and potassium thiocyanate (1.04 g, 10.7 mmol) were stirred in EtOH (35 mL) for 3h at 5O0C. S- Trityl-L-cysteine (3.64 g, 10.0 mmol), triethylamine (1.5 mL, 11.0 mmol) and EtOH (15 mL) were added. The reaction mixture was stirred at 5O0C for 16 h. The ethanol was removed in vacuum and the residue was partitioned between water and EtOAc. The water phase was twice extracted with EtOAc. The combined organic extracts were washed with water, brine, dried over anhydrous Na2SO4 and concentrated. The crude product was purified by flash column chromatography using gradient elution <n="96"/>from CH2Cl2/Et0H (9:1) to CH2Cl2/Et0H (7:1) to give 3.37 g (63percent) of (R)-2-(5- methyl-4-phenyl-thiazol-2-ylamino)-3-tritylsulfanyl-propionic acid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58.33% | With bromine; acetic acid; at -10 - 20℃; | Preparation of Intermediate 2-amino-7,8-dihydrothiazolo[4,5-h]isoquinolin-9(6H)-one (I-66b) Potassium thiocyanate (8.62 g, 0.088 mol) was added to a stirred solution of <strong>[66491-03-0]7-amino-3,4-dihydroisoquinolin-1(2H)-one</strong> (I-66a: 1.8 g, 0.01 mol) in acetic acid (60 mL) at -10 C. and this was followed by the addition of bromine (5.33 g, 0.033 mol). The resulting reaction mass was stirred at -10 C. for 3 hours and further at room temperature overnight. The reaction was monitored by TLC (100% ethyl acetate). The reaction mass was diluted with ice water and filtered. The resulting mixture was basified at 0 C. using KOH solution to pH 10 and extracted using ethyl acetate. The organic layer was concentrated under reduced pressure to afford the crude product. Purification by column chromatography on silica gel (20% ethyl acetate in hexane) afforded 1.4 g of the product (58.33% yield). 1H NMR (300 MHz, DMSO): delta 8.04 (s, 1H), 7.4 (t, 3H), 7.14 (d, 1H), 3.46-3.3 (m, 2H), 2.9 (t, 2H). LCMS: 94.14%, m/z=294.3 (M+1) |
(I-66b) Potassium thiocyanate (8.62g, 0.088mol) was added to a stirred solution of 7- amino-3,4-dihydroisoquinolin-l(2H)-one (I-66a: 1.8g, 0.01 mol) in acetic acid (60mL) at -10C and this was followed by the addition of bromine (5.33g, 0.033mol). The resulting reaction mass was stirred at -10C for 3 hours and further at roomtemperature overnight. The reaction was monitored by TLC (100% ethyl acetate). The reaction mass was diluted with ice water and filtered. The resulting mixture was basified at 0C using KOH solution to pH 10 and extracted using ethyl acetate. The organic layer was concentrated under reduced pressure to afford the crude product. Purification by column chromatography on silica gel (20% ethyl acetate in hexane) afforded 1.4g of the product (58.33% yield).1H NMR (300 MHz, DMSO): delta 8.04 (s, 1H), 7.4 (t, 3H), 7.14 (d, 1H), 3.46- 3.3(m, 2H), 2.9 (t, 2H). LCMS: 94.14%, m/z = 294.3 (M+l) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | In ethanol; water; at 20 - 60℃; for 24h;Sealed tube; | General procedure: 4,4?-Dmo-2,2?-bpy (0.22 g, 1 mmol) was placed in oneof the arms of a branched tube [32], and zinc(II) acetatedihydrate (0.11 g, 0.5 mmol) and potassium thiocyanate(0.10 g, 1 mmol) were placed in the other arm. Ethanoland water in a ratio of 3:2 were carefully added to fill botharms. The tube was then sealed and the ligand-containingarm was immersed in a bath at 60°C, whereas the otherwas maintained at ambient temperature. After 1 day, crystalsthat were deposited in the cooler arm were filtered off,washed with mother liquid, and dried in air, yield: 0.18 g,59percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | In ethanol; water; at 20 - 60℃; for 24h;Sealed tube; | 4,4?-Dmo-2,2?-bpy (0.22 g, 1 mmol) was placed in oneof the arms of a branched tube [32], and zinc(II) acetatedihydrate (0.11 g, 0.5 mmol) and potassium thiocyanate(0.10 g, 1 mmol) were placed in the other arm. Ethanoland water in a ratio of 3:2 were carefully added to fill botharms. The tube was then sealed and the ligand-containingarm was immersed in a bath at 60°C, whereas the otherwas maintained at ambient temperature. After 1 day, crystalsthat were deposited in the cooler arm were filtered off,washed with mother liquid, and dried in air, yield: 0.18 g,59percent. ? C26H24N6O4S2Zn (614.02): calcd. C 50.81, H 3.91, N13.68; found C 51.05, H 4.10, N 13.44. ? IR (KBr): nu = 3081 w(C?Har), nu = 3022, 2977 w (C?H), 2066 and 2088 vs. (CNSCN), 1614 s (C = Npy), 1561 m (C = Car), 1405 m, 1337 vs, 1218 vs,1034 vs, rhow = 837 vs. (C?Har), nu = 819 w (CS), delta = 480 w(NCS) cm?1.? 1H NMR (250 MHz, [D6]DMSO, ppm): delta = 8.23(m, 4H, Ca,dH), 7.25 (d, 2H, CcH), 3.99 (s, 6H, CfH3). ? 13CNMR (62 MHz, [D6]DMSO, ppm): delta = 168.90 (Cb), 151.37 (Ce),149.48 (Cd), 132.76 (CSCN), 112.86 (Ca), 109.41 (Cc), 57.06 (Cf). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | With hydrogenchloride; In water; at 100℃; for 24h; | To a stirred solution of <strong>[6358-77-6]5-bromo-2-methoxyaniline</strong> (1 g, 4.95 mmol) in conc. HC1 (5 mL) and water (20 mL) was added potassium thiocyanate (0.48 1 g, 4.95 mmol) and the reaction mixture was heated at 100 C for 24 h. The reaction mixture was allowed to cool to room temperature. Water (150 mL) was added and thesolution was extracted with CHC13 (3 x 80 mL). The combined organic extracts were washed with brine (150 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (EtOAc in hexanes) to afford 1-(5-bromo-2-methoxyphenyl)thiourea (960 mg, 2.94 mmol, 59% yield) as a white solid. LCMS (ESI) m/e 261.0 [(M+2H), calcd forC8H10BrN2OS, 260.91; LC/MS retention time (method Al) tR = 2.09 mm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
43% | With hydrogenchloride; In water; at 20℃; for 16h;Darkness; | To a solution ofhydrochloric acid(12 mL, 0.25 M, 3 mmol) was added potassium thiocyanate (0.291 g, 3 mmol) and 4-iodophenylhydrazine (3 mmol). 3-pentanone (3 mmol) was added to the solution dropwise. The reaction was allowed to stir in the dark for 16 hours at room temperature. The precipitate thatformed was filtered using vacuum filtration and washed with water four times. The precipitatewas then recrystallized with methanol yield 5,5-diethyl-2-(4-iodophenyl)-1,2,4-triazolidine-3-thione as a white-orange solid (m.p = 161 °e, 43percent). 1H (400 MHz, DMSO-d6) 8 9.43 (s, 1H), 7.91(d, J=8.8, 2H), 7.67 (d, J=8.8, 2H), 6.57 (s, 1H), 1.62-1.57 (m, 4H), 0.879 (t, J=7.2, 3H) ppm; Be NMR (100 MHz, DMSO-d6) 8 175.6, 140.0, 136.5, 122.7, 87.6, 79.0, 29.1, 7.6 ppm; IR Vmax (em·1) 3180, 2970, 1498, 1376, 815; HRMS (ESI) calcd for e12H16IN3S [M+Ht 362.01824, found362.01763. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With bromine; acetic acid; at 0 - 20℃; | Potassium thiocyanate (0.73 8 g, 7.59 mmol) was dissolved in acetic acid (5 mL) and cooled to 0 C. <strong>[886372-63-0]5-fluoro-6-methoxypyridin-3-amine</strong> (1.079 g, 7.59 mmol) was dissolved in acetic acid (1.667 mL) and added dropwise. Bromine (0.782 mL, 15.18mmol) was dissolved in acetic acid (1.667 mL) and added dropwise to the reaction. The reaction mixture was allowed to warm to room temperature and stir overnight. The reaction mixture was concentrated under reduced pressure. The resultant residue was diluted with water and neutralized with 1 N NaOH. The aqueous solution was extracted with EtOAc x3. The combined organic layer was washed with brine, dried with sodiumsulfate, and concentrated under reduced pressure to yield Intermediate I-131A (1.496 g,7.51 mmol, 99 %yield). ?HNMR(400MHz, CDC13)oe 7.49(d,J=10.6Hz, 1H), 5.14(br. s., 2H), 4.03 (s, 3H). LC-MS: method H, RT = 0.65 mm, MS (ESI) m/z: 200.0 (M+H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With hydrogenchloride; In 1,4-dioxane; water; at 110℃; for 48h; | 4,6-Dichloropyridin-3-amine (int-57) (1.5 g, 9.3 mmol) and potassium thiocyanate (2.69 g, 27.8 mmol) were dissolved in dioxane (30 mL) and concentrated aq. HC1 (0.1 mL) was added. The solution was stirred at 1 1() C for 2 days. Then, the solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel using a mixture of petroleum ether and EtOAc (1:1) as eluent to give 6-chlorothiazolo[4,5-cjpyridin-2-arnine (int?58) (1.3 g, 76percent yield) as a yellow solid. MS (ESI): mz 185.9 [M+H]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetone; at 20℃; | General procedure: 4-(bromomethyl)-2H-chromen-2-one [24]/4-(bromomethyl)- quinolin-2(1H)-one [25] 1(0.01 mol equiv) was taken in 20 mL of acetone in a round-bottom flask. To this, potassiumthiocyanate (0.012 mol equiv) was added with stirring, which was continued for 12?14 h (reaction was monitored by TLC). The reaction mixture was then poured into ice-coldwater. Separated solid was filtered, dried and used in the next step. |
Tags: 333-20-0 synthesis path| 333-20-0 SDS| 333-20-0 COA| 333-20-0 purity| 333-20-0 application| 333-20-0 NMR| 333-20-0 COA| 333-20-0 structure
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P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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