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Chemical Structure| 93-40-3 Chemical Structure| 93-40-3
Chemical Structure| 93-40-3

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3,4-Dimethoxyphenylacetic Acid is the main metabolite of 3,4-dimethoxyphenylethylamine (DMPEA) in urine.

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Product Details of 3,4-Dimethoxyphenylacetic acid

CAS No. :93-40-3
Formula : C10H12O4
M.W : 196.20
SMILES Code : C1=CC(=CC(=C1OC)OC)CC(O)=O
MDL No. :MFCD00004335
InChI Key :WUAXWQRULBZETB-UHFFFAOYSA-N
Pubchem ID :7139

Safety of 3,4-Dimethoxyphenylacetic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3,4-Dimethoxyphenylacetic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93-40-3 ]

[ 93-40-3 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 93-40-3 ]
  • [ 68285-26-7 ]
  • [ 121443-80-9 ]
  • 2
  • [ 93-40-3 ]
  • [ 40505-27-9 ]
  • 4-O-(3,4-dimethoxybenzoic acid)-4-deoxy-4'-demethylepipodophyllotoxin [ No CAS ]
  • 3
  • [ 93-40-3 ]
  • [ 16582-58-4 ]
  • 2-(2-(3,4-dimethoxyphenyl)acetamide)-6-iodobenzothiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
50% With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; N,N-dimethylformamide solution (3 ml) containing <strong>[16582-58-4]2-amino-6-iodobenzothiazole</strong> (200 mg, 0.723 mmol) and 3,4-dimethoxyphenylacetic acid (157 mg, 0.795 mmol) was added with N,N-diisopropylethylamine (139 mul, 0.803 mmol) and 0-(6-chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (360 mg, 0.870 mmol) and stirred over night at room temperature. After completion of the reaction, the solution was diluted with ethyl acetate and washed with saturated sodium bicarbonate solution and saturated sodium chloride solution. The solution was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. The residue was recrystallized with ethanol and 167 mg of 2-(2-(3,4-dimethoxyphenyl)acetamide)-6-iodobenzothiazole was obtained in a yield of 50%. 1H NMR (DMSO-d6): delta 12.61 (s, 1H), 8.37 (s, 1H), 7.73-7.69 (m, 1H), 7.54 (d, J=8.0 Hz, 1H), 6.97-6.84 (m, 3H), 3.75-3.72 (m, 8H). MS (ESI) Found; 455[M+H]+
  • 4
  • [ 93-40-3 ]
  • [ 876343-24-7 ]
  • 2-(3,4-dimethoxyphenyl)-N-(1-ethyl-1H-pyrazol-4-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% General procedure: A mixture of bromoacetic acid (2 mmol), HOBt (2 mmol) and EDC (2 mmol) in dichloromethane was stirred for 30 min at room temperature. Then 3a (2 mmol) was added to the solution. The reaction was stirred for 16 h at room temperature. Finally, reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (30 mL × 3). The organic layer was concentrated in vacuum and subjected to flash column chromatography to give compound 4a.A mixture of 2-(3,4-dimethoxyphenyl) acetic acid (2 mmol), HOBt (2 mmol) and EDC (2 mmol) in dichloromethane was stirred for 30 min at room temperature. Then 3a (2 mmol) was added to the solution. The reaction was stirred for 16 h at room temperature. Finally, reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (30 mL × 3). The organic layer was concentrated in vacuum and subjected to flash column chromatography to give compound 5a.
  • 5
  • [ 93-40-3 ]
  • [ 369-26-6 ]
  • C18H18FNO5 [ No CAS ]
  • 6
  • [ 93-40-3 ]
  • [ 347-84-2 ]
  • 1-benzyl-1-(4-fluorophenyl)-6,7-dimethoxyisochroman-3-one [ No CAS ]
 

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