931-53-3|Cyclohexylisocyanide| Ambeed

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Structure of 931-53-3

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Quality Control of [ 931-53-3 ] Purity: 98% SDS Specification

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Product Details of [ 931-53-3 ]

CAS No. :	931-53-3
Formula :	C₇H₁₁N
M.W :	109.17
SMILES Code :	[C-]#[N+]C1CCCCC1
MDL No. :	MFCD00003839
InChI Key :	XYZMOVWWVXBHDP-UHFFFAOYSA-N
Pubchem ID :	79129

Safety of [ 931-53-3 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H227-H301+H311+H331-H315-H319
Precautionary Statements:	P210-P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P370+P378-P403+P233-P405-P501
Class:	6.1
UN#:	2810
Packing Group:	Ⅱ

Application In Synthesis of [ 931-53-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 931-53-3 ]

[ 931-53-3 ] Synthesis Path-Downstream 1~35

1
[ 931-53-3 ]
[ 42548-78-7 ]
[ 75-07-0 ]
[ 40934-32-5 ]

References: [1]Justus Liebigs Annalen der Chemie,1973,p. 359 - 364.

2
[ 931-53-3 ]
[ 42548-78-7 ]
[ 123-72-8 ]
[ 40934-34-7 ]

References: [1]Justus Liebigs Annalen der Chemie,1973,p. 359 - 364.

3
[ 931-53-3 ]
[ 4214-79-3 ]
[ 123-38-6 ]
[ 104-86-9 ]
2-(N-(4-chlorobenzyl)-N-(5-chloropyridin-2-yl)amino)-N-cyclohexylbutanamide [ No CAS ]

References: [1]Journal of Organic Chemistry,2007,vol. 72,p. 4169 - 4180.

4
[ 931-53-3 ]
[ 42182-27-4 ]
[ 123-11-5 ]
[ 1311991-81-7 ]

References: [1]Journal of the American Chemical Society,2011,vol. 133,p. 10058 - 10061.

5
[ 931-53-3 ]
[ 104-88-1 ]
[ 1701-18-4 ]
[ 107-11-9 ]
[ 1352943-18-0 ]

References: [1]Organic Letters,2012,vol. 14,p. 476 - 478.

6
[ 931-53-3 ]
[ 104-88-1 ]
[ 1701-18-4 ]
[ 109-85-3 ]
[ 1352943-20-4 ]

References: [1]Organic Letters,2012,vol. 14,p. 476 - 478.

7
[ 931-53-3 ]
[ 1701-18-4 ]
[ 107-11-9 ]
[ 590-86-3 ]
[ 1352943-17-9 ]

References: [1]Organic Letters,2012,vol. 14,p. 476 - 478.

8
[ 931-53-3 ]
[ 109466-87-7 ]
[ 1383956-64-6 ]

References: [1]Tetrahedron Letters,2012,vol. 53,p. 3619 - 3622.

9
[ 931-53-3 ]
[ 109466-87-7 ]
[ 107-95-9 ]
[ 1383956-69-1 ]

Yield	Reaction Conditions	Operation in experiment
		General procedure for the preparation of compound 5: The beta-amino acid (1.2 mmol, 1.2 equiv) and the nitro-aldehyde (1.0 mmol, 1.0 equiv.) were dissolved in 20 ml ethanol-water (2:1). The solution was allowed to stand at room temperature for half an hour. The isocyanide (1.0 mmol, 1.0 equiv.) was added to the previous solution and the resulting mixture was stirred at room temperature for 20 h, when the reaction appeared complete by TLC (CH2Cl2:MeOH 98:2), Fe powder (1 mmol) and solid NH4Cl (8-10 equiv.) were added. The reaction mixture was stirred at 80 0C for 16 h. Then it was cooled, filtered through a celite pad and extracted with ethyl acetate (3×30 mL). The extract was washed with brine (30 mL) and dried (sodium sulphate); the solvent was evaporated to give a crude product. This was purified by column chromatography over silica gel (60-120 mesh) using DCM in 5% methanol as an eluent, when 5a was isolated as a light yellow solid. The compounds 5b-h were prepared accordingly.

References: [1]Tetrahedron Letters,2012,vol. 53,p. 3619 - 3622.

10
[ 931-53-3 ]
[ 7311-34-4 ]
[ 494-52-0 ]
(+)-N-cyclohexyl-2-(3,5-dimethoxyphenyl)-2-[2-(pyridin-3-yl)piperidin-1-yl]acetamide [ No CAS ]

References: [1]Chemistry of Heterocyclic Compounds,2012,vol. 48,p. 606 - 612,7.
Khimiya Geterotsiklicheskikh Soedinenii,2012,vol. 48,p. 651 - 657,7.

11
[ 1918-77-0 ]
[ 372-19-0 ]
[ 931-53-3 ]
[ 5780-66-5 ]
[ 1395081-24-9 ]

References: [1]ACS Medicinal Chemistry Letters,2012,vol. 3,p. 850 - 855.

12
[ 931-53-3 ]
[ 32161-30-1 ]
[ 67-64-1 ]
[ 22483-09-6 ]
C₂₅H₄₁N₃O₆ [ No CAS ]

References: [1]Chemistry - A European Journal,2013,vol. 19,p. 8048 - 8052.

13
[ 931-53-3 ]
[ 32161-30-1 ]
N-cyclohexyl-2-((1R,5S)-8,9-dimethoxy-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocin-11-yl)-2-methylpropanamide [ No CAS ]

References: [1]Chemistry - A European Journal,2013,vol. 19,p. 8048 - 8052.

14
[ 931-53-3 ]
[ 157869-15-3 ]
(E)-N-(1-cyclohexyl-3-(4-methoxyphenyl)pyrrolo[2,3-b]indol-2(1H)-ylidene)cyclohexanamine [ No CAS ]

References: [1]Chemical Communications,2015,vol. 51,p. 9519 - 9522.

15
[ 931-53-3 ]
[ 157869-15-3 ]
C₂₉H₃₅N₃O [ No CAS ]

References: [1]Chemical Communications,2015,vol. 51,p. 9519 - 9522.

16
[ 931-53-3 ]
[ 5417-17-4 ]
(2-chloro-3,4-dimethoxyphenyl)(1-cyclohexyl-1H-tetrazol-5-yl)methanol [ No CAS ]

References: [1]Green Chemistry,2016,vol. 18,p. 3718 - 3721.

17
[ 96-50-4 ]
[ 931-53-3 ]
[ 33985-71-6 ]
N-cyclohexyl-6-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)imidazo[2,1-b]thiazol-5-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	In toluene; at 100℃; for 0.166667h;Microwave irradiation; Sealed tube;	General procedure: General Procedure (GP): In a MW sealed-tube equipped with a magnetic stirring bar, to a 0.5 M solution of aldehyde (1.0 equiv.) in anhydrous toluene [0.5 M], amine (1.0 equiv.) and isocyanide (1.0 equiv.) were added sequentially and the reaction mixture was MW-heated (100 oC,150 W) for 10 minutes. Then, the solvent was removed until dryness and the crude was immediately purified by silica-gel column chromatography using a mixture of hexanes with ethyl acetate (7/3; v/v) to afford the corresponding products 1a-w.

References: [1]Tetrahedron Letters,2016,vol. 57,p. 3556 - 3560.

18
[ 136-95-8 ]
[ 931-53-3 ]
[ 33985-71-6 ]
N-cyclohexyl-2-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)benzo[d]imidazo[2,1-b]thiazol-3-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	In toluene; at 100℃; for 0.166667h;Microwave irradiation; Sealed tube;	General procedure: General Procedure (GP): In a MW sealed-tube equipped with a magnetic stirring bar, to a 0.5 M solution of aldehyde (1.0 equiv.) in anhydrous toluene [0.5 M], amine (1.0 equiv.) and isocyanide (1.0 equiv.) were added sequentially and the reaction mixture was MW-heated (100 oC,150 W) for 10 minutes. Then, the solvent was removed until dryness and the crude was immediately purified by silica-gel column chromatography using a mixture of hexanes with ethyl acetate (7/3; v/v) to afford the corresponding products 1a-w.

References: [1]Tetrahedron Letters,2016,vol. 57,p. 3556 - 3560.

19
[ 931-53-3 ]
[ 5847-59-6 ]
[ 630-19-3 ]
2-(2-bromo-4-nitrophenoxy)-N-cyclohexyl-3,3-dimethylbutanamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With 1,4-diaza-bicyclo[2.2.2]octane; In neat (no solvent); at 55℃; for 12h;	General procedure: To 1.0 equiv. of phenol were added successively 1.0 equiv. of DABCO, 2.0 equiv. of aldehyde, and 1.0 equiv. of isocyanide. The resulting mixture was stirred neat at 80 C for 12 h. The crude product was dissolved in dichloromethane. The organic layer was washed with 1 M NaOH, water, dried over MgSO4 and then concentrated. The crude product was purified by flash chromatography on silica gel.

References: [1]Molecules,2016,vol. 21.

20
[ 931-53-3 ]
[ 40230-24-8 ]
[ 123-08-0 ]
4-(3-(cyclohexylamino)-5,7-diphenylimidazo[1,2-a]pyrimidin-2-yl)phenol [ No CAS ]