Structure of 42548-78-7
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CAS No. : | 42548-78-7 |
Formula : | C2H8ClNO |
M.W : | 97.54 |
SMILES Code : | ONCC.[H]Cl |
MDL No. : | MFCD00144881 |
InChI Key : | LTZZYVWUGIPISL-UHFFFAOYSA-N |
Pubchem ID : | 10219386 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 5 |
Num. arom. heavy atoms | 0 |
Fraction Csp3 | 1.0 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 22.22 |
TPSA ? Topological Polar Surface Area: Calculated from |
32.26 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
0.0 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
0.47 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
0.79 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
0.18 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
-0.81 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
0.13 |
Log S (ESOL):? ESOL: Topological method implemented from |
-0.67 |
Solubility | 20.6 mg/ml ; 0.211 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-0.72 |
Solubility | 18.7 mg/ml ; 0.192 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
0.02 |
Solubility | 103.0 mg/ml ; 1.05 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.56 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.43 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of the compound prepared in Example 5(15) (912 mg) in ethanol (10 mL) were added pyridine (5 mL) and O-<strong>[42548-78-7]ethylhydroxyamine hydrochloride</strong> (340 mg) and the solution was refluxed for 3 hours. After finishing the reaction, the reaction solution was concentrated. Water and 2N hydrochloric acid were added thereto and the solution was extracted with ethyl acetate. The organic layer was washed with brine and concentrated. The obtained residue was purified by column chromatography on silica gel (ethyl acetate: methanol=25:1) and 4N hydrogen chloride/ethyl acetate solution was added to the obtained residue, which was concentrated to give the compound of the present invention (E-form: 409 mg, Z-form: 500 mg) having the following physical data. E-form: TLC:Rf 0.37(chloroform:methanol=10:1); NMR (CD3OD): delta 1.29 (t, J=7.0 Hz, 3H), 1.90-2.00 (m, 2H), 2.14-2.28 (m, 2H), 2.86-2.96 (m, 2H), 3.38-3.48 (m, 3H), 4.16 (s, 2H), 4.18 (q, J=7.0 Hz, 2H), 7.02 (d, J=9.0 Hz, 2H), 7.11 (d, J=9.0 Hz, 2H), 7.36 (d, J=9.0 Hz, 2H), 7.50 (d, J=9.0 Hz, 2H), 7.52 (d, J=9.0 Hz, 2H), 8.00 (d, J=9.0 Hz, 2H). Z-form: TLC:Rf 0.35(chloroform;methanol=10:1); NMR (CD3OD): delta 1.16 (t, J=7.0 Hz, 3H), 1.76-1.91 (m, 2H), 2.43-2.14 (m, 2H), 2.89 (m, 1H), 3.02-3.11 (m, 2H), 3.50-3.58 (m, 2H), 4.03 (q, J=7.0 Hz, 2H), 4.31 (s, 2H), 7.06 (d, J=9.0 Hz, 2H), 7.16 (d, J=9.0 Hz, 2H), 7.25 (d, J=9.4 Hz, 2H), 7.55 (d, J=9.0 Hz, 2H), 7.57 (d, J=9.0 Hz, 2H), 8.03 (d, J=9.0 Hz, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; water; ethyl acetate; | Example 49 9-(2-Ethyloximino-3-nonyl)-2-(2-n-propoxyphenyl)-purin-6-one STR91 412 mg (1 mmol) of 9-(2-oxo-3-nonyl)-2-(2-n-propoxyphenyl)-purin-6-one (Example 48) are dissolved in 10 ml of methanol, and 117 mg (1.2 mmol) of <strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong>, dissolved in 1.5 ml of water, are added. The mixture is boiled under reflux for 2 hours, cooled and evaporated in vacuo. The residue is taken up in 10 ml of ethyl acetate and washed with 10 ml of saturated NaHCO3 solution. After the organic phase has been dried with Na2 SO4, the solvent is distilled off in vacuo and the residue is purified by flash chromatography (eluent: toluenelacetone 4:1). Rf =0.53 (toluene/acetone 1:1) Yield: 366 mg (80.8percent) The oximes listed in Table III are prepared in accordance with these instructions using the corresponding hydroxylamine hydrochlorides (all the oximes are in the form of cis/trans mixtures). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | EXAMPLE 3 The reaction is carried out under the same conditions as those described in Example 2, except that the following reactants are used: Crystalline N-ethylhydroxylamine hydrochloride is obtained with a yield of 72percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In tetrahydrofuran; pyridine; dichloromethane; water; | EXAMPLE 14 3-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)-N-ethyl-N-hydroxypropanamide A stirring solution of 8.98 g of <strong>[42548-78-7]N-<strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong></strong> in 300 ml of dry pyridine was chilled, degassed using several vacuum/N2 cycles, and treated dropwise over several minutes with a solution of 9.00 g of 3-(6,11-dihydro-11-oxodibenz[b,e]-oxepin-2-yl)propanyl chloride in 200 ml of dry tetrahydrofuran. The solution was allowed to equilibrate to room temperature overnight. The reaction was quenched with 200 ml of water, concentrated in vacuo to remove solvents, and partitioned against a total of 250 ml of methylene chloride and 600 ml of 10percent hydrochloric acid (pH of the resulting aqueous phase was below 1). The organic phase was washed with 500 ml of water, dried (Na2 SO4), and concentrated to an oil in vacuo. The oil was triturated with 25percent hexane/ethyl acetate to give 6.11 g of solids, which were recrystallized from hexane/ethyl acetate to give 4.56 g of 3-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)-N-ethyl-N-hydroxypropanamide, m.p. 120° C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In tetrahydrofuran; pyridine; thionyl chloride; dichloromethane; water; | EXAMPLE 10 2-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)-N-ethyl-N-hydroxypropanamide To a flask was added a solution of a few drops of dimethylformamide and 50.0 g of 2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)propionic acid in 500 ml of methylene chloride, and the solution was chilled. To the chilled solution was added dropwise over several minutes, 13.14 ml of thionyl chloride. The solution was intermittenly warmed on a steam bath until all gas evolution had ceased, and was then allowed to stir for 24 hours. The solution was concentrated to an oil in vacuo to remove solvents and any unreacted thionyl chloride to give 45.4 g of the pure acid chloride. A stirring solution of 10.14 g of <strong>[42548-78-7]N-<strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong></strong> in 350 ml of dry pyridine was chilled and treated dropwise over several minutes with a solution of 8.0 g of 2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)propionyl chloride in 400 ml of tetrahydrofuran. The solution was allowed to equilibrate to room temperature overnight (16 hours) with continued stirring. The reaction was quenched with 500 ml of water and concentrated in vacuo to remove solvents. The product mixture was partitioned against a total of 500 ml of methylene chloride and 1000 ml of 10percent HCl (pH of aqueous layers <1). The organic phase was washed with 500 ml of water, dried (Na2 SO4) and concentrated in vacuo to an oil. Thin layer analysis indicated a mixture, which was separated twice via preparative HPLC to give 2.65 g of 2-(6,11-dihydro-11-oxodibenz[b,e]-oxepin-2-yl)-N-ethyl-N-hydroxypropanamide, as an oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In tetrahydrofuran; pyridine; dichloromethane; water; | EXAMPLE 4 2-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)-N-ethyl-N-hydroxyacetamide To a flask was added 4.0 g of <strong>[42548-78-7]N-<strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong></strong> in 300 ml of dry pyridine. The mixture was stirred to afford a solution, chilled with an ice bath, and was treated dropwise over several minutes with a solution of 5.72 g of 2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl) acetyl chloride in 200 ml of dry tetrahydrofuran. The solution was stirred for 24 hours while allowing the bath to equilibrate to room temperature. The resulting suspension was condensed to an oil via rotary evaporation and was then transferred to a separatory funnel. The product was partitioned against 500 ml of methylene chloride and a sufficient amount (250 ml) of 10percent HCl to acidify the aqueous phase below pH 1. The organic phase was then washed with 250 ml of water. The dried (Na2 SO4) organic phase was filtered and concentrated to an oil using rotary evaporation. Thin layer analysis indicated a mixture, which was separated via HPLC to give 3.03 g of pure material. The product was combined with another lot of identically prepared material, which was found to be pure by thin layer analysis. The total amount of combined material was 4.53 g. Recrystallization from acetone afforded 2-(6,11-dihyrdo-11-oxodibenz[b,e]-oxepin-2-yl)-N-ethyl-N-hydroxyacetamide, m.p. 119°-121° C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With triethylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 18.0h; | To 1 -(2,4-difluorobenzyl)-3-({4-hydroxy-4-t(2-oxopyrrolidin-1 -yl)methyl]piperidin-1 -yl}methyl)-1 H- pyrrolo[2,3-c]pyridine-5-carboxyiic acid (0.4 g, 0.8 mmol) in DMF (10 mL) were added HATU ( 0.669 g, 1.76 mmol), triethylamine (0.446 ml, 3.2 mmol), and /V-<strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong> [prep, ace. . Baillie, L C; Batsanov, A. Bearder, J. R.; Whiting, D. J.Chem.Soc.Perkin Trans.1 ; 1998, 20, 3471-3478] (0.270 g, 1.76 mmol). The resulting mixture was stirred for 18 hours at ambient temperature. The solvent was evaporated and the residue was dissolved in methanol and purified by preparative HPLC to provide the title compound as a white powder (0.237 g, 55% yield). 1 H NMR (300 MHz, MeOH) delta ppm 8.88 (s, 1 H) 8.31 (s, 1 H) 7.88 (s, 1 H) 7.35 - 7.44 (m, 1 H) 6.94 - 7.07 (m, 2 H) 5.64 (s, 2 H) 4.34 (s, 2 H) 3.87 - 3.97 (m, 2 H) 3.58 - 3.69 (m, 4 H) 3.12 - 3.22 (m, 2 H) 3.02 - 3.12 (m, 2 H) 2.33 - 2.40 (m, 2 H) 1.95 - 2.07 (m, 4 H) 1.68 - 1.79 (m, 5 H); LC-MS (APCI, M+H+): 542.3. HPLC: 96% purity. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium acetate; In ethanol; dichloromethane; water; | EXAMPLE VI 2-(1-(Ethoxyimino)propyl)-3-hydroxy-5-(4-(5-(trifluoromethyl)-3-fluoro-2-pyridylthio)phenyl)cyclohex-2-en-1-one STR44 To a slurry of 2.10 g (0.00478 mol) of 2-propionyl-3-hydroxy-5-(4-((5-(trifluoromethyl)-3-fluoro-2-pyridylthio)phenyl)cyclohex-2-en-1-one in 75 mL of ethanol was added 0.61 g (0.0621 mol) of o-<strong>[42548-78-7]ethylhydroxyamine hydrochloride</strong> and 0.59 g (0.00717 mol) of anhydrous sodium acetate. The slurry was stirred at ambient temperature for 19 hours and then diluted with 100 mL of methylene chloride and 150 mL of water. The organic layer was separated and washed twice with 150 mL portions of water and dried over sodium sulfate. The solvent was removed in vacuo leaving 2.05 g (89 percent of theoretical) of the crude product. The product was purified by column chromatography using methylene chloride as eluent. Recrystallization form hexane afforded 1.6 g (70 percent of theoretical) of the above named title compound, melting at 91°-92° C.; Rf -0.36 (silica gel, 20:80 acetone:hexane), 1 H NMR (CDCl3): delta1.0-1.4 (m, 6H, CH3 CH2 -- and CH3 CH2 O--), 2.50-3.65 (m, 7H, ring protons and CH3 CH2 --), 4.05 (q, 2H, CH3 CH2 O--), 7.15-8.65 (m, 6H, ArH), 15.0 (broad s, 1H, OH). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
2. alpha-(1-methyl-2-nitroimidazole-5-yl)-N-ethylnitrone, m.p. 138°-139°, by reacting 1-methyl-2-nitro-5-imidazolecarboxaldehyde with <strong>[42548-78-7]N-<strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong></strong> |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In methanol; | Example 1 A mixture of 5-[2-(3,4-difluorophenylthio)ethyl]-3-hydroxy-2-propionyl-2-cyclohexen-1-one (3.40 g), O-<strong>[42548-78-7]ethylhydroxyamine hydrochloride</strong> (1.39 g) and triethylamine (1,5 g) in methanol (50 ml) was stirred at room temperature. After twelve hours stirring the reaction mixture was poured into water and then acidified with diluted hydrochloric acid, followed by extraction with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate filtered and the solvent was distilled off under reduced pressure. The residue was purified through column chromatography (eluent: hexane:ethyl acetate = 85:15) to obtain 3.25 9 of 5-[2-(3,4-difluorophenylthio)ethyl]-3-hydroxy-2-(1-ethoxyiminopropyl)-2-cyclohexen-1-one. n [20/D ] 1.5576. | |
With triethylamine; In methanol; | Example 2 5-[2-(3,4-difluorophenylthio)ethyl]-3-hydroxy-2 propionyl-2-cyclohexen-1-one (3.40 g), O-<strong>[42548-78-7]ethylhydroxyamine hydrochloride</strong> (1.39 g) and triethylamine (1.5 g) were dissolved in methanol (50 ml). The mixture was stirred for twelve hours at room temperature. The solvent was distilled off under reduced pressure, and the resulting residue was mixed with ethyl acetate (60 ml). The organic layer was washed with diluted hydrochloric acid and water successively. Then the extract was dried over anhydrous magnesium sulfate, filtered and evaporated to give crude product. The product was column chromatographed on silica gel (eluent; hexane:ethyl acetate = 5:1) to give 3.30 g of 5-[2-(3,4-difluorophenylthio)ethyl]-3-hydroxy-2-(1-ethoxyiminopropyl)-2-cyclohexen-1-one. n [20/D ] 1.5576 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium acetate; In methanol; at 85℃; for 1.0h; | EXAMPLE 167; E/Z mixture 6-({2,6-Dichloro-4-[N-ethoxyethanimidoyl]phenyl}amino)pyrido[4,3-c]-l ,6- naphthyridin- 10(9H)-one; Step 1 : To a solution of 6-[(4-acetyl-2,6-dichlorophenyl)amino]pyrido[4,3-c]-l ,6- naphthyridin-10(9H)-one (Examples 144 and 145, Step 3) (20 mg, 0.50 mmol) in MeOH (1 mL) was added N-hydroxyethanamine HCl (24 mg, 0.25 mmol) and sodium acetate (21 mg, 0.25 mmol). The solution was heated to 850C for 1 hr then cooled to room temperature and extracted with 3 : 1 CHCl3/iPrOH and water. The organic layers were dried with MgSO4, filtered, and concentrated under reduced pressure. Purification by silica gel chromatography (100percent CH2Cl2 to 70percent CH2Cl2 30percent MeOH) provided the product as a mixture of rotamers and E/Z isomers. LRMS (ESI) calc'd for C21Hi8Cl2N5O2 [M+H]+, 442.1; found 442.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | In methanol; at 20℃; for 3.0h;Molecular sieve; | A solution of (E)-methyl 2-(2-((3-formylphenoxy)methyl)phenyl)-3-methoxyacrylate (0.10 g, 0.306 mmol) in Step 1 and <strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong> (45 mg, 1.5 eq) in 7 mL of methanol was stirred at room temperature for 3 hours in the presence of a molecular sieve for dehydration and filtered through celite.After concentration of the filtrate in a vacuum, the residue was stirred in water (10 mL) and extracted twice with 15 mL of dichloromethane.The organic layer was dried over anhydrous magnesium sulfate and concentrated in a vacuum.Purification of the residue by silica gel chromatography afforded 80 mg of (E)-methyl 2-(2-((3-((E)-(ethoxyimino)methyl)phenoxy)methyl)phenyl)-3-methoxyacrylate as a white oil (yield: 71percent).m/s [M+1]=370.101H NMR (300 MHz, CDCl3): delta 8.12 (s, 1H), 7.60 (s, 1H), 7.56-7.53 (m, 2H), 7.44 (s, 1H), 7.36-7.32 (m, 2H), 7.26-7.23 (m, 1H), 7.20-7.18 (m, 1H), 6.76-6.75 (d, 1H), 5.01 (s, 2H), 4.12-4.08 (q, 2H), 3.84 (s, 3H), 3.72 (s, 3H), 1.30-1.27 (t, 3H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 22℃; for 16.0h; | Example P.4: (E/Z)-2-chloro-N-ethoxy-ethanimine:A mixture of chloracetyl chloride (26.99 g, 170 mmol) and ethyl hydroxalamine hydrochloride (22.3 g, 230 mmol, 1 .33 equiv.) was stirred at 22°C for 16 h. Water (150 mL) was added and the mixture was extracted with ether twice. The combined organic layers were washed with brine, dried over sodium sulfate and evaporated at 30°C and 200 mbar to obtainthe title compound (18.18 g, 87percent) as an 67:33 E/Z mixture which was used in the next step as such.Characterization by 1H-NMR (400 MHz, CDCI3): oe[delta] = 1.24 (t, 3H), 4.12 (m, 2H), 4.13- 4.21 (m, 2H), 6.80 & 7.41 (2xt, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
8.86 g | With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0℃; for 0.75h;Reflux; | To a suspension of (4R)-2-oxooxazolidine-4-carboxylic acid (10.0 g, 75.9 mmol) in dry THF (50 ml) was added three drops of DMF followed by a dropwise addition of oxalyl chloride (7.31 ml, 83.5 mmol) at 0C. After the addition the reaction mixture was stirred for another 30 min at ambient temperature. In a separate flask triethylamine (37.2 ml, 266 mmol) was slowly added to a solution of N- <strong>[42548-78-7]ethylhydroxylamine hydrochloride</strong> in THF (100 ml). To this formed thick white suspension was added a solution of acid chloride prepared above over 45 min at 0 C. After finishing of addition the reaction mixture was warmed up to ambient temperature, additional THF (50 ml) was added and the reaction mixture was brought to reflux. The remaining precipitate (triethylamine hydrochloride) was filtered off and the filtrate was concentrated under reduced pressure to afford crude product (15.9 g). Quantitative NMR analysis using trimethoxy benzene as an internal standard indicated that the mixture contains (4R)- N-ethyl-N-hydroxy-2-oxo-oxazolidine-4-carboxamide (11.39 g) as the major component. Crystallization of the crude product from methanol afforded (4R)-N-ethyl-N-hydroxy-2-oxo-oxazolidine-4-carboxamide (8.86 g) as a white powder. (0813) lH NMR (400MHz, D20) delta 5.01 (dd, J = 9.9, 5.9 Hz), 4.77 (t, J = 9.2 Hz, 1H), 4.39 (dd, J = 9.0, 5.7 Hz, 1H), 3.65 (q, J = 7.1 Hz, 2H), 1.16 (t, J = 7.1 Hz, 3H). |
Tags: 42548-78-7 synthesis path| 42548-78-7 SDS| 42548-78-7 COA| 42548-78-7 purity| 42548-78-7 application| 42548-78-7 NMR| 42548-78-7 COA| 42548-78-7 structure
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Code | Phrase |
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P103 | Read label before use |
Prevention | |
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P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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