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[ CAS No. 7758-99-8 ] Copper sulfate pentahydrate

Cat. No.: A148190
Chemical Structure| 7758-99-8
Chemical Structure| 7758-99-8
Structure of 7758-99-8 * Storage: Inert atmosphere,Room Temperature

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* Storage: Inert atmosphere,Room Temperature

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Product Citations

Product Citations

Elbatrawy, Ahmed A ; Ademoye, Taiwo A ; Alnakhala, Heba , et al. DOI:

Abstract: Alzheimer’s (AD) and Parkinson’s (PD) disease are neurodegenerative disorders that are considered to be a significant global health challenge due to their increasing prevalence and profound impact on both individuals and society. These disorders are characterized by the progressive loss of neuronal function, leading to cognitive and motor impairments. A key pathological feature of AD and PD is the abnormal accumulation of misfolded proteins within the brain. In AD, amyloid-beta aggregates into plaques, while tau proteins form neurofibrillary tangles (NFTs). Parkinson’s disease, on the other hand, is marked by the accumulation of α-synuclein (α-syn) in the form of Lewy bodies (LBs). These protein aggregates are involved in neuronal dysfunction and neurodegeneration, contributing to disease progression. Research efforts are increasingly focused on identifying small molecules that can simultaneously target multiple pathological processes, offering the potential to not only alleviate symptoms but also modify the progression of neurodegeneration. Herein, a novel group of triazole-based compounds was designed and synthesized to curtail the aggregation of α-syn and tau proteins, which are closely linked to the physiopathology of PD and AD, respectively. A thioflavin T (ThT) fluorescence assay was used to measure fibril formation and assess the antiaggregation effects of various compounds. To further validate these findings, transmission electron microscopy (TEM) was employed as a direct method to visualize the impact of these compounds on fibril morphology. Inhibition of oligomer formation was evaluated using photoinduced cross-linking of unmodified proteins (PICUP), enabling the detection of early protein aggregation events. During fibril formation assays, three compounds (3e, 4b, 4d) demonstrated superior inhibitory activity as assessed by ThT fluorescence and TEM imaging. Subsequent evaluations, which included tests for antioligomer, anti-inclusion, and disaggregation effects identified compound 4d as the most promising candidate overall.

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Product Details of [ 7758-99-8 ]

CAS No. :7758-99-8 MDL No. :MFCD00149681
Formula : CuH10O9S Boiling Point : -
Linear Structure Formula :- InChI Key :JZCCFEFSEZPSOG-UHFFFAOYSA-L
M.W : 249.69 Pubchem ID :24463
Synonyms :
Chemical Name :Copper(II) sulfate pentahydrate

Calculated chemistry of [ 7758-99-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 0
Fraction Csp3 : None
Num. rotatable bonds : 0
Num. H-bond acceptors : None
Num. H-bond donors : None
Molar Refractivity : 25.76
TPSA : 134.79 Ų

Pharmacokinetics

GI absorption : None
BBB permeant : None
P-gp substrate : None
CYP1A2 inhibitor : None
CYP2C19 inhibitor : None
CYP2C9 inhibitor : None
CYP2D6 inhibitor : None
CYP3A4 inhibitor : None
Log Kp (skin permeation) : None cm/s

Lipophilicity

Log Po/w (iLOGP) : None
Log Po/w (XLOGP3) : None
Log Po/w (WLOGP) : None
Log Po/w (MLOGP) : None
Log Po/w (SILICOS-IT) : None
Consensus Log Po/w : None

Druglikeness

Lipinski : None
Ghose : None
Veber : None
Egan : None
Muegge : None
Bioavailability Score : None

Water Solubility

Log S (ESOL) : None
Solubility : None mg/ml ; None mol/l
Class : None
Log S (Ali) : None
Solubility : None mg/ml ; None mol/l
Class : None
Log S (SILICOS-IT) : None
Solubility : None mg/ml ; None mol/l
Class : None

Medicinal Chemistry

PAINS : None alert
Brenk : None alert
Leadlikeness : None
Synthetic accessibility : None

Safety of [ 7758-99-8 ]

Signal Word:Danger Class:9
Precautionary Statements:P264-P270-P273-P280-P301+P312+P330-P305+P351+P338+P310-P391-P501 UN#:3077
Hazard Statements:H302-H318-H410 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 7758-99-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 7758-99-8 ]
  • Downstream synthetic route of [ 7758-99-8 ]

[ 7758-99-8 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 625-92-3 ]
  • [ 7758-99-8 ]
  • [ 4318-78-9 ]
Reference: [1] Recueil des Travaux Chimiques des Pays-Bas, 1936, vol. 55, p. 122,126
[2] Chemische Berichte, 1936, vol. 69, p. 1534,1536
  • 2
  • [ 2457-47-8 ]
  • [ 7758-99-8 ]
  • [ 4318-78-9 ]
Reference: [1] Roczniki Chemii, 1938, vol. 18, p. 39,41[2] Chemisches Zentralblatt, 1939, vol. 110, # I, p. 1366
  • 3
  • [ 64-17-5 ]
  • [ 2457-47-8 ]
  • [ 7664-41-7 ]
  • [ 7758-99-8 ]
  • [ 22353-34-0 ]
Reference: [1] Roczniki Chemii, 1938, vol. 18, p. 39,41[2] Chemisches Zentralblatt, 1939, vol. 110, # I, p. 1366
  • 4
  • [ 822-16-2 ]
  • [ 7758-99-8 ]
  • [ 660-60-6 ]
Reference: [1] Gmelin Handbuch, Gmelin Handbook: Cu: MVol.B2, 44, page 715 - 717,
[2] 8th int. Congr. appl. Chem., Washington-New York 1912, Bd. 11, S. 7/11,
[3] Annalen der Physik (Weinheim, Germany), 1852, vol. 87, p. 553 - 587
[4] Journal fuer Praktische Chemie (Leipzig), 1855, vol. 66, p. 1 - 51
[5] Gmelin Handbuch, Gmelin Handbook: Cu: MVol.B2, 44, page 715 - 717,
  • 5
  • [ 593-29-3 ]
  • [ 7758-99-8 ]
  • [ 660-60-6 ]
Reference: [1] Russian Journal of Inorganic Chemistry (Translation of Zhurnal Neorganicheskoi Khimii), 1979, vol. 24, p. 213 - 216[2] Russ. J. Inorg. Chem. (Transl. of Zh. Neorg. Khim.), 1979, vol. 24, p. 384 - 388
[3] Thermochimica Acta, 1982, vol. 52, p. 121 - 130
  • 6
  • [ 148-24-3 ]
  • [ 7758-99-8 ]
  • [ 10380-28-6 ]
Reference: [1] Investigational New Drugs, 2017, vol. 35, # 6, p. 682 - 690
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