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Chemical Structure| 7758-99-8 Chemical Structure| 7758-99-8
Chemical Structure| 7758-99-8

Copper sulfate pentahydrate

CAS No.: 7758-99-8

4.5 *For Research Use Only !

Cat. No.: A148190 Purity: 99%

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Product Citations

Product Citations

Elbatrawy, Ahmed A ; Ademoye, Taiwo A ; Alnakhala, Heba ; Tripathi, Arati ; Zhu, Xiongwei ; Plascencia-Villa, Germán , et al.

Abstract: Alzheimer’s (AD) and Parkinson’s (PD) disease are neurodegenerative disorders that are considered to be a significant global health challenge due to their increasing prevalence and profound impact on both individuals and society. These disorders are characterized by the progressive loss of neuronal function, leading to cognitive and motor impairments. A key pathological feature of AD and PD is the abnormal accumulation of misfolded proteins within the brain. In AD, amyloid-beta aggregates into plaques, while tau proteins form neurofibrillary tangles (NFTs). Parkinson’s disease, on the other hand, is marked by the accumulation of α-synuclein (α-syn) in the form of Lewy bodies (LBs). These protein aggregates are involved in neuronal dysfunction and neurodegeneration, contributing to disease progression. Research efforts are increasingly focused on identifying small molecules that can simultaneously target multiple pathological processes, offering the potential to not only alleviate symptoms but also modify the progression of neurodegeneration. Herein, a novel group of triazole-based compounds was designed and synthesized to curtail the aggregation of α-syn and tau proteins, which are closely linked to the physiopathology of PD and AD, respectively. A thioflavin T (ThT) fluorescence assay was used to measure fibril formation and assess the antiaggregation effects of various compounds. To further validate these findings, transmission electron microscopy (TEM) was employed as a direct method to visualize the impact of these compounds on fibril morphology. Inhibition of oligomer formation was evaluated using photoinduced cross-linking of unmodified proteins (PICUP), enabling the detection of early protein aggregation events. During fibril formation assays, three compounds (3e, 4b, 4d) demonstrated superior inhibitory activity as assessed by ThT fluorescence and TEM imaging. Subsequent evaluations, which included tests for antioligomer, anti-inclusion, and disaggregation effects identified compound 4d as the most promising candidate overall.

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Product Details of Copper sulfate pentahydrate

CAS No. :7758-99-8
Formula : CuH10O9S
M.W : 249.69
SMILES Code : O=S([O-])([O-])=O.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Cu+2]
MDL No. :MFCD00149681
InChI Key :JZCCFEFSEZPSOG-UHFFFAOYSA-L
Pubchem ID :24463

Safety of Copper sulfate pentahydrate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H318-H410
Precautionary Statements:P264-P270-P273-P280-P301+P312+P330-P305+P351+P338+P310-P391-P501
Class:9
UN#:3077
Packing Group:

Application In Synthesis of Copper sulfate pentahydrate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 7758-99-8 ]
  • Downstream synthetic route of [ 7758-99-8 ]

[ 7758-99-8 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 625-92-3 ]
  • [ 7758-99-8 ]
  • [ 4318-78-9 ]
References: [1] Recueil des Travaux Chimiques des Pays-Bas, 1936, vol. 55, p. 122,126.
[2] Chemische Berichte, 1936, vol. 69, p. 1534,1536.
  • 2
  • [ 2457-47-8 ]
  • [ 7758-99-8 ]
  • [ 4318-78-9 ]
References: [1] Roczniki Chemii, 1938, vol. 18, p. 39,41[2] Chemisches Zentralblatt, 1939, vol. 110, # I, p. 1366.
  • 3
  • [ 64-17-5 ]
  • [ 2457-47-8 ]
  • [ 7664-41-7 ]
  • [ 7758-99-8 ]
  • [ 22353-34-0 ]
References: [1] Roczniki Chemii, 1938, vol. 18, p. 39,41[2] Chemisches Zentralblatt, 1939, vol. 110, # I, p. 1366.
  • 4
  • [ 822-16-2 ]
  • [ 7758-99-8 ]
  • [ 660-60-6 ]
References: [1] Gmelin Handbuch, Gmelin Handbook: Cu: MVol.B2, 44, page 715 - 717, .
[2] 8th int. Congr. appl. Chem., Washington-New York 1912, Bd. 11, S. 7/11, .
[3] Annalen der Physik (Weinheim, Germany), 1852, vol. 87, p. 553 - 587.
[4] Journal fuer Praktische Chemie (Leipzig), 1855, vol. 66, p. 1 - 51.
[5] Gmelin Handbuch, Gmelin Handbook: Cu: MVol.B2, 44, page 715 - 717, .
  • 5
  • [ 593-29-3 ]
  • [ 7758-99-8 ]
  • [ 660-60-6 ]
References: [1] Russian Journal of Inorganic Chemistry (Translation of Zhurnal Neorganicheskoi Khimii), 1979, vol. 24, p. 213 - 216[2] Russ. J. Inorg. Chem. (Transl. of Zh. Neorg. Khim.), 1979, vol. 24, p. 384 - 388.
[3] Thermochimica Acta, 1982, vol. 52, p. 121 - 130.
  • 6
  • [ 148-24-3 ]
  • [ 7758-99-8 ]
  • [ 10380-28-6 ]
References: [1] Investigational New Drugs, 2017, vol. 35, # 6, p. 682 - 690.
 

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