Structure of 66655-67-2
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 66655-67-2 |
Formula : | C8H8N2O |
M.W : | 148.16 |
SMILES Code : | O=C1NC2=C(C=CC=C2)CN1 |
MDL No. : | MFCD03425132 |
InChI Key : | CTOUNZIAEBIWAW-UHFFFAOYSA-N |
Pubchem ID : | 12360756 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P261-P280-P305+P351+P338 |
Num. heavy atoms | 11 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.12 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 1.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 48.84 |
TPSA ? Topological Polar Surface Area: Calculated from |
41.13 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
1.26 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
0.89 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
0.22 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
1.07 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
1.23 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
0.93 |
Log S (ESOL):? ESOL: Topological method implemented from |
-1.72 |
Solubility | 2.8 mg/ml ; 0.0189 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-1.34 |
Solubility | 6.8 mg/ml ; 0.0459 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-2.92 |
Solubility | 0.178 mg/ml ; 0.0012 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.57 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.75 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Reference Example 177 6-(5-Chloropentanoyl)-3,4-dihydro-2(1H)-quinazoline Using 3,4-dihydro-2(1H)-quinazoline (4.0 g) and 5-chlorovaleryl chloride (8.37 g) according to the same method as that of Reference Example 1, the title compound was obtained as colorless crystals (3.9 g) 1H NMR (200MHz, DMSO-d6) delta 1.73 (4H, m), 2.96 (2H, t, J = 7.0 Hz), 3.67 (2H, t, J = 6.4 Hz), 4.38 (2H, s), 6.83 (1H, d, J = 8.8 Hz), 7.01 (1H, s), 7.75-7.80 (2H, m), 9.44 (1H, s). MS m/z: 267 [M+H]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | In methanol; water; ethyl acetate; | Example 3 3-(2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)propionaldehyde Benzoylene urea (4.0 g, 24.7 mmol), Triton B (40 wt % in methanol) (11.0 mL, 24.7 mmol), water (80 mL) and methanol (400 mL) were combined at ambient temperature and stirred vigorously for 15 minutes. (until all the solids had gone into solution). To this colorless solution, acrolein (1.7 mL, 24.7 mmol) in methanol (20 mL) was added dropwise over 5 minutes. to give a yellow solution. The reaction was then heated to 55 C and stirred for 2 hours. and then at room temperature for approximately 16 hours. The yellow solution was concentrated to give a yellow oil which was taken up in ethyl acetate (25 mL) and water (50 mL). The aqueous layer was extracted again with ethyl acetate (25 mL). The organic layers were combined, washed with 1N HCl (20 mL), water (20 mL), saturated sodium bicarbonate solution (20 mL) and brine (20 mL), the organic layer was dried over magnesium sulfate and concentrated to give 3-[2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]propionaldehyde as a yellow foam (3.2 g, 59%) which was used without further purification. The NMR data showed a purity of ~70%. NMR CDCl3 delta 9.85 (s, 1H), 8.10-8.06 (m, 1H), 7.63-7.57 (m, 1H), 7.24-7.19 (m, 1H), 7.13-7.07 (m, 1H), 4.44-4.40 (m, 2H), 2.85 (dt, 2H, J1,2=2 Hz, J1,3=7 Hz); MS=219 (p+1). |
59% | In hydrogenchloride; methanol; water; ethyl acetate; | Example 5 Preparation of 3-[2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl]propionaldehyde Benzoylene urea (4.0 g, 24.7 mmol), Triton B (40 wt % in methanol) (11.0 mL, 24.7 mmol), water (80 mL) and methanol (400 mL) were combined at ambient temperature and stirred vigorously for 15 minutes. (until all the solids had gone into solution). To this colorless solution, acrolein (1.7 mL, 24.7 mmol) in methanol (20 mL) was added dropwise over 5 minutes. to give a yellow solution. The reaction was then heated to 55 C. and stirred for 2 hours. and then at room temperature for approximately 16 hours. The yellow solution was concentrated to give a yellow oil which was taken up in ethyl acetate (25 mL) and water (50 mL). The aqueous layer was extracted again with ethyl acetate (25 mL). The organic layers were combined, washed with IN HCl (20 mL), water (20 mL), saturated sodium bicarbonate solution (20 mL) and brine (20 mL), the organic layer was dried over magnesium sulfate and concentrated to give 3-[2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]propionaldehyde as a yellow foam (3.2 g, 59%) which was used without further purification. The NMR data showed a purity of 70%. NMR CDCl3 delta 9.85 (s, 1H), 8.10-8.06 (m, 1H), 7.63-7.57 (m, 1H), 7.24-7.19 (m, 1H), 7.13-7.07 (m, 1H), 4.44-4.40 (m, 2H), 2.85 (dt, 2H, J1,2=2 Hz, J1,3=7 Hz); MS=219 (p+1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
10.4% | In N-methyl-acetamide; water; | i) Synthesis of 1,3-bis[3-(4-pyridylthio)propyl]-quinazoline-2,4(1H,3H)-dione To a solution of 1.62 g (10 mmol) of benzoylene urea and 1.88 g (10 mmol) of 4-(3-chloropropylthio)pyridine in 50 ml of dimethylformamide, 1.65 ml (11 mmol) of 1,8-diazabicyclo[5.4.0]-7-undecene was added, and the mixture was stirred at 80 C. for 16 hours. After cooling, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried and the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate/ethanol =25:1 to 10:1 to 2:1). First, 0.973 g of 3-[3-(4-pyridylthio)propyl]quinazoline-2,4-(1H,3H)-dione (31.1% yield, pale yellow crystals) was obtained, and then, 0.487 g of the desired product was obtained (10.4% yield, yellow oil). NMR (200 MHz, CDCl3) delta: 2.04-2.24 (4H, m), 3.02-3.16 (4H, m), 4.27-4.35 (4H, m), 7.08-7.30 (6H, m), 7.62 (1H, ddd, J=1.8, 7.0, 7.2 Hz), 8.23 (1H, dd, J=1.6, 8.0 Hz), 8.35-8 41 (4H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95.3% | aluminium chloride; In dichloromethane; | Example 6 6-(3-Chloro-1-oxopropyl)-<strong>[66655-67-2]1,2,3,4-tetrahydroquinazolin-2-one</strong> 20 g of aluminium chloride (0.15 mol) are taken up in 100 ml of dichloromethane. 7.43 g of <strong>[66655-67-2]1,2,3,4-tetrahydroquinazolin-2-one</strong> (0.05 mol) are added in portions with stirring at a maximum of 20 C. The reaction mixture thus obtained is subsequently stirred for 30 minutes. A solution consisting of 6.98 g of 3-chloropropionyl chloride (0.055 mol) and 50 ml of dichloromethane is then added dropwise with stirring at a temperature of at most 25 C. and the mixture is subsequently stirred for a further hour. After completion of the reaction, the reaction mixture obtained is stirred into 300 g of ice, and the precipitate is filtered off with suction and washed with plenty of water and small amounts of methanol. The reaction forms a slightly more polar product than the starting material, which can be separated by thin-layer chromatography using an eluent consisting of chloroform and methanol in the mixture ratio 95:5. Yield: 11.37 g of 6-(3-chloro-1-oxopropyl)-<strong>[66655-67-2]1,2,3,4-tetrahydroquinazolin-2-one</strong> (95.3% of theory); m.p: >270 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride;aluminium trichloride; In carbon disulfide; | Step 1. 6-(3-Carboxy-propionyl)-<strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> 3,4-Dihydro-2(1H)-quinazolinone (4.8 g) is added to a stirred suspension of anhydrous aluminum chloride (21.7 g) in carbon disulfide (100 ml) under nitrogen. Methyl succinyl chloride (4.9 g) is added dropwise to the stirred suspension, the reaction mixture refluxed for about 70 hours, cooled to RT and the liquid phase decanted. The residue is treated with ice and 6N HCl, filtered, and the solid air dried, affording the desired crude product, M.P. 176-180 C., which is used in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride;aluminium trichloride; In carbon disulfide; | Step 1 6-(Bromoacetyl)-<strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> Bromoacetyl chloride (6.2 g) is added dropwise to a stirring mixture of <strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> (2.6 g) and anhydrous aluminum chloride (6.3 g) in carbon disulfide (60 ml). The reaction mixture is stirred under reflux for 4.5 hours, the carbon disulfide decanted, and the residue treated with HCl (6N). The resulting solid is poured into ice water, filtered, the filtered solid washed with water and dried in vacuo, affording the desired product, which is used in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride;aluminium trichloride; In carbon disulfide; | Step 1 6-(2-Bromopropionyl)-<strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> 2-Bromopropionyl bromide (10.6 g) is added dropwise to a stirring mixture of <strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> (3.2 g) and anhydrous aluminum chloride (7.9 g) in carbon disulfide (60 ml). The reaction mixture is refluxed for four hours, the carbon disulfide decanted and the residue treated with aqueous hydrochloric acid (6N). The acidic residue is poured into ice water, and the precipitate filtered, washed with water and dried, affording the desired product as a solid, which is used in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
aluminium trichloride; In carbon disulfide; diethyl ether; water; | Step 1. 6-(3-Carbomethoxy-2-methyl-propionyl)-<strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> 3,4-Dihydro-2(1H)-quinazolinone (3.6 g) is added to a stirred suspension of anhydrous aluminum chloride (16.5 g) in carbon disulfide (120 ml) under nitrogen. 3-Carbomethoxy-2-methyl-propionyl chloride (4 g) is added dropwise to the stirred suspension, and the reaction mixture refluxed for about 18 hours, cooled to RT and further cooled to 0 C. in an ice bath. The liquid phase is decanted and ice and cold water slowly added to the residue. The aqueous mixture is filtered and the filtered solid suspended and stirred in the anhydrous diethyl ether overnight. The suspension is filtered and the filtered solid used in the next step without further purification. | |
aluminium trichloride; In carbon disulfide; diethyl ether; water; | Step 1. 6-(3-Carbomethoxy-2-methyl-propionyl)-<strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> 3,4-Dihydro-2(1H)-quinazolinone (3.6 g) is added to a stirred suspension of anhydrous aluminum chloride (16.5 g) in carbon disulfide (120 ml) under nitrogen. 3-Carbomethoxy-2-methyl-propionyl chloride (4 g) is added dropwise tothe stirred suspension, and the reaction mixture refluxed for about 18 hours, cooled to RT and further cooled to 0 C. in an ice bath. The liquid phase is decanted and ice and cold water slowly added to the residue. The aqueous mixture is filtered and the filtered solid suspended and stirred in the anhydrous diethyl ether overnight. The suspension is filtered and the filtered solid used in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | In tetrahydrofuran;Inert atmosphere; | Triphosgene (3.31 g, 12.3 mmol) was added toa solution of 2-(aminomethyl)aniline (1.50 g, 12.3 mmol) in 30 ml THF under a nitrogenatmosphere. After precipitation of a colorless solid, stirring was continued for 30 minbefore water was added. The solution was extracted several times with ethyl acetate. Thecombined organic layers were washed with brine and dried over anhydrous MgSO4 toafford 10b (1.80 g, 12.2 mmol, 99 %) as colorless solid. 1H-NMR (500 MHz, DMSO-d6):delta = 4.30 (s, 2H), 6.75-6.77 (m, 2H), 6.84 (ddd, 3J = 3J = 7.4 Hz, 4J = 1.9 Hz, 1H), 7.06 (d,3J = 7.3 Hz, 1H), 7.09 (dd, 3J = 3J = 7.7 Hz, 1H), 8.98 (s, 1H). 13C-NMR (125 MHz,DMSO-d6): delta = 42.4, 113.4, 118.0, 120.8, 125.5, 127.4, 138.0, 154.5. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0℃; for 2.0h; | A solution of N-bromosuccinimide(2.26 g, 12.7 mmol) in 30 ml dry DMF was added drop wise to a solution of 10b (1.79 g,12.1 mmol) in 35 ml dry DMF at 0 C. The mixture was stirred at 0 C for 2 h. Waterwas added and the solution was extracted with ethyl acetate. The organic layer waswashed with brine, and then dried over anhydrous MgSO4. The resulting yellow solidwas purified by crystallization from acetone to afford 10a (1.37 g, 6.00 mmol, 50 %) aswhite solid. 1H-NMR (500 MHz, DMSO-d6): delta = 4.29 (s, 2H), 6.71 (d, 3J = 8.2 Hz, 1H),6.87 (s, 1H), 7.27 (dd, 3J = 8.4 Hz, 4J = 2.3 Hz, 1H), 7.29 (s, 1H), 9.13 (s, 1H). 13C-NMR(125 MHz, DMSO-d6): delta = 41.9, 112.0, 115.3, 120.7, 128.2, 130.1, 137.5, 154.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
12% | With copper diacetate; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 95℃; | General procedure: The reaction was performed in a double-chamber system [67,68]. Amine/amines, Pd(OAc)2(0.05 equiv.) and Cu(OAc)2 (0.5 equiv.) were added to the reaction chamber and dissolved in1,4-dioxane (2 mL). In the CO-chamber was Mo(CO)6 (200 mg) dissolved in 1,4-dioxane (2 mL).After capping of the system, 1,8-diazabicyclo[5.4.0]undec-7-ene was added to the CO-chamber.The double-chamber system was positioned in a Dry-Syn heating block and heated to 95 C. Aftercompletion of the reaction, the reaction mixture was filtered through a short silica plug before flashcolumn chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91.8% | In N,N-dimethyl-formamide; at 80℃; for 2.0h; | To <strong>[66655-67-2]3,4-dihydroquinazoline-2(1H)-one</strong> (1.7 g, 11.6 mmol)N,N-dimethylformamide dimethyl acetal (5.5 g, 46.3 mmol) was added dropwise to the DMF solution (10 ml), and the mixture was reacted at 80 C for 2 h.Water (28 ml) and ethyl acetate (15 ml) were added, and the mixture was evaporated, evaporated, evaporated, evaporated, evaporated Concentrated to a crude product,The crude product was separated by column chromatography (eluent: petroleum ether: ethyl acetate = 10:1)The yield relative to <strong>[66655-67-2]3,4-dihydroquinazoline-2(1H)-one</strong> was 91.8%.The product purity is 99.6%(mass fraction) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89.8% | In N,N-dimethyl-formamide; at 80℃; for 2.0h; | To a solution of <strong>[66655-67-2]3,4-dihydroquinazoline-2(1H)-one</strong> (0.3 g, 2.0 mmol) in DMF (4 mL)N,N-dimethylformamide diethyl acetal (1.0 g, 8.2 mmol) was added dropwise.The reaction was carried out at 80 C for 2 h.Water (10 ml) and ethyl acetate (10 ml) were added.The organic layer was combined, washed with brine, dried over anhydrous sodium sulfateThe filtrate was concentrated under reduced pressure to give a crude material.Ethyl acetate = 10:1) separation,A white solid (0.32 g, yield 89.8%) was obtained.Product purity is 99.4%(mass fraction) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84.2% | In N,N-dimethyl-formamide; at 80℃; for 2.0h; | To <strong>[66655-67-2]3,4-dihydroquinazoline-2(1H)-one</strong> (0.7 g, 4.7 mmol)DMF solution (4ml)N,N-dimethylformamide diisopropyl acetal (3.2 g, 27.2 mmol) was added dropwise.The reaction was carried out at 80 C for 2 h.Add water (18 ml) and ethyl acetate (15 ml), and separate.The aqueous layer was extracted with ethyl acetate (15×2 mL).Dry over anhydrous sodium sulfate, filter, and concentrate the filtrate under reduced pressure.The crude product was separated by column chromatography (eluent: petroleum ether: ethyl acetate = 10:1).A white solid (0.75 g, yield: 84.2%) was obtainedProduct purity is 99.4%(mass fraction) |
A164894 [41921-63-5]
4,5-Dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one
Similarity: 0.87
A287574 [67014-36-2]
5-Amino-6-methyl-1H-benzo[d]imidazol-2(3H)-one
Similarity: 0.81
A264417 [1246765-38-7]
6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Similarity: 0.80
A532977 [59674-85-0]
7-Aminoquinazoline-2,4(1H,3H)-dione
Similarity: 0.80
A264417 [1246765-38-7]
6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Similarity: 0.80
A532977 [59674-85-0]
7-Aminoquinazoline-2,4(1H,3H)-dione
Similarity: 0.80
A177886 [67449-23-4]
8-Methylquinazoline-2,4(1H,3H)-dione
Similarity: 0.79
A227883 [79098-75-2]
3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one
Similarity: 0.75