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Chemical Structure| 7148-74-5 Chemical Structure| 7148-74-5

Structure of 7148-74-5

Chemical Structure| 7148-74-5

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Product Details of [ 7148-74-5 ]

CAS No. :7148-74-5
Formula : C3H4BrClO
M.W : 171.42
SMILES Code : O=C(Cl)C(Br)C
MDL No. :MFCD00000711
InChI Key :OZGMODDEIHYPRY-UHFFFAOYSA-N
Pubchem ID :97980

Safety of [ 7148-74-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H302-H312-H314-H332
Precautionary Statements:P210-P280-P305+P351+P338-P310
Class:3(8)
UN#:2924
Packing Group:

Application In Synthesis of [ 7148-74-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7148-74-5 ]

[ 7148-74-5 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 28170-13-0 ]
  • [ 555-30-6 ]
  • [ 7148-74-5 ]
  • [ 72634-60-7 ]
  • 2
  • [ 19932-85-5 ]
  • [ 7148-74-5 ]
  • 6-bromo-3-(2-bromo-propionyl)-3<i>H</i>-benzooxazol-2-one [ No CAS ]
  • 3
  • [ 66655-67-2 ]
  • [ 7148-74-5 ]
  • [ 109916-28-1 ]
  • 4
  • [ 7148-74-5 ]
  • [ 42538-40-9 ]
  • [ 882068-31-7 ]
YieldReaction ConditionsOperation in experiment
Introduce 28.8 g of <strong>[42538-40-9](S)-2-bromophenylalanine</strong>, 7.5 ml of water and 15 ml of toluene into a reactor; then bring the mixture to between 0 and 5° C. and add 25 ml of 5M sodium hydroxide solution and then a solution of 20.2 g of (2R)-2-bromopropionyl chloride in toluene, whilst keeping the temperature below 10° C. and maintaining the pH of the mixture at 10 by adding 5M sodium hydroxide solution. After stirring for a further 1 hour at 10° C., add concentrated hydrochloric acid to bring the pH of the mixture to 6. Separate off the toluene phase and then add concentrated hydrochloric acid to the aqueous phase to bring the pH to 2. The precipitate formed is then filtered off and dried to yield the title compound.
  • 5
  • [ 142009-99-2 ]
  • [ 7148-74-5 ]
  • C16H20BrNO2 [ No CAS ]
  • 6
  • [ 35613-44-6 ]
  • [ 7148-74-5 ]
  • methyl 2-(2-(2-bromopropionamido)phenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With sodium carbonate; In tetrahydrofuran; at -78℃; for 1.5h; Methyl 2- (2-aminophenyl) acetate (0.71 g, 4.3 mmol) andSodium carbonate (0.16g, 1.6mmol)Dissolved in tetrahydrofuran (10mL),Reduce the temperature to -78 and stir for 1h.2-bromopropionyl chloride (0.77g, 4.5mmol) andTetrahydrofuran (5mL) was mixed slowly and completely within 0.5 hours.After the addition is complete, move to room temperature and stir for 5h.Methyl 2- (2- (2-bromopropionamide) phenyl) acetate (white solid, 1.16 g) was obtained in a yield of 90%.
 

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[ 7148-74-5 ]

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