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Structure of 532-55-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 532-55-8 |
Formula : | C8H5NOS |
M.W : | 163.20 |
SMILES Code : | O=C(N=C=S)C1=CC=CC=C1 |
MDL No. : | MFCD00004815 |
InChI Key : | CPEKAXYCDKETEN-UHFFFAOYSA-N |
Pubchem ID : | 68284 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H301-H317-H318 |
Precautionary Statements: | P261-P264-P270-P272-P280-P301+P310-P302+P352-P305+P351+P338-P310-P321-P330-P333+P313-P363-P405-P501 |
Class: | 8(6.1) |
UN#: | 2922 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | for 3 h; Reflux | To the solution of benzylisothiocyanate (83.0 g, 509.3 mmol) in acetone (700mL) was added compound 6-methylpyridin-2 -amine (50 g, 463.0mmol) in acetone (600 ml) dropwise, then the reaction mixture was stirred at reflux for 3h. The reaction mixture was poured on to crushed ice, then filtered and washed with water, water/MeOH (1 : 1) and MeOH to give l-benzoyl-3-(6- methylpyridin-2-yl)thiourea as a yellow solid (100.1 g, yield 80percent). To a solution of 1-benzoyl-3-(6-methylpyridin-2-yl)thiourea (60 g,221.4 mmol) in THF ( 1000 ml) was added 2N NaOH (243.5ml), then heated at reflux for 3 h. Cooled to RT and filtered to give (6-methylpyridin-2- yl)thiourea as a white solid (34.1 g, yield 92percent). A mixture of (6-methylpyridin-2-yl)thiourea (13.2 g, 79.16 mmol) and 2-bromo-l-(4-bromophenyl)ethan-l-one (22 g, 79.16 mmol) in ethanol (300 mL) was stirred at reflux for 3h, then concentrated and purified with silica gel column to give N-[4-(4-bromophenyl)-l,3-thiazol-2-yl]-6-methylpyridin-2-amine as a yellow solid (14.3 g,53percent). A solution of N-[4-(4-bromophenyl)-l,3-thiazol-2-yl]-6-methylpyridin-2-amine (5 g. 14.5mmol), Bis(pinacolato)diboron (4.8 g, 18.8mmol), Pd(dppf)2Ci2 (1.2 mg, 1.5mmol) and AcOK (4.3 g, 43.3mmol) in dioxane (100ml) was heated to 80 under 2 overnight. The mixture was evaporated to give (6-methyl-N-{4-[4-(tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl]-l,3-thiazol-2-yl}pyridin-2-amine). Coupling (200mg) with 2-dimethylamino-4- bromopyridine under standard conditions gave 33 mg from 200 mg of, yellow solid, 17 percent yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: Benzoylchloride was added drop wise to a stirred solution of NH4SCN inacetone and stirred at 50°C for 2 hours. Next, a solution of substitutednaphthylamines in acetone was added drop wise, and the mixture wasstirred at 50oC for 24 hours. The reaction mixture was diluted withwater; the precipitated crystals collected by filtration and washedwith water. The crystals were then suspended in 2M NaOH (50 ml),refluxed for 1 hour, and poured into cold water and filtered. The crudecrystals of the resulting thiourea were dissolved in acetic acid, towhich benzyl trimethylammonium tribromide was added and allowedto react overnight. Ethyl ether (Et2O) was added and the precipitate ofthe resulting product-HBr salt was collected by filtration and washedwith Et2O. The salt was then treated with 1M NaOH to liberate thefree base, which was recrystallized in methanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87.2% | With 2,2-dimethyl-N-(7-methyl-6-oxo-6,7-dihydro-1H-purin-2-yl)-propionamide; In ethanol; water; for 2.0h; | Intermediate LL (4.0 g, 31.74 mmol) was dissolved by warming in water (200 mL). A mixture of benzoyl isothiocyanate (5.7 g, 34.92 mmol) and ethanol (200 mL) was added slowly to the rapidly stirred solution of compound J. The mixture was stirred for 2 hours, during which time the sides of the flask were frequently scraped clean of adhering solid. At this time, the solid was collected, washed with hot ethanol (50 mL), and dried to yield Intermediate MM as a pale yellow solid (8g, 87.2%). 1H NM (300 MHz, DMSO-<¾): delta 13.68 (s, 1H), 13.3 (s, 1H), 1 1.4 (s, 1H), 9.09 (s, 1H), 7.96 (d, J= 7.5 Hz, 2H), 7.71 (bs, 1H), 7.66-7.63 (m, 1H), 7.55-7.51 (m, 2H), 7.41 (bs, 1H), Mass (M+H): 290 (100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | In acetonitrile; at 20℃; for 1h; | A mixture of <strong>[76045-71-1]3-amino-5-hydoxybenzoic acid</strong> (30.7 g, 200.7 MMOL) and benzoylisothiocyanate (26.57 g) in acetonitrile (450 mL) was stirred at room temperature for 1 h. The precipitate was filtered and washed with acetonitrile and dried to afford 57.17 g (90%) of the desired product as a YELLOW POWDER. 1H NMR (CD30D) 8 8.01-8. 04 (m, 2H), 7.79 (m, 1 H), 7.69 (m, 1 H), 7.58-7. 63 (m, 2H), 7.37 (m, 1H). ANAL. CALCD FOR C15H12N2SO4 : Mol. Wt, 316.0518. Found. 317.0593 (M+H, HRMS). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In chloroform; at 61℃; for 2.5h; | [0555] (b) Preparation of N-([(2-chloro-6-nitrophenyl)methyl]-amino}thioxomethyl)benzamide. To solution of <strong>[101252-73-7](2-chloro-6-nitrophenyl)methylamine</strong> (Step a) (3.19 g, 17 mmol) in 100 mL CHCl3 was added benzoyl isothiocyanate (2.3 mL, 17 mmol) and the reaction was heated to 61 C. After 2.5 h, the reaction was cooled to RT and purified by flash chromatography with hexanes:EtOAc (9:1, 4:1, 13:7, 1:1) as eluant to give an off-white amorphous solid. MS m/z: 348 (M-1). Calc'd for C15H12ClN3O3S-349.03. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57.7% | In tetrahydrofuran; ethanol; | Example 15 <strong>[32326-25-3]<strong>[32326-25-3]3-amino-5-methoxyisoxazol</strong>e</strong> (1.2 g) was dissolved in tetrahydrofuran (10 ml) and benzoylisothiocyanate (2.2 g) was added dropwise thereto at 2-3 C. After the mixture was stirred for 1 hour, the reaction mixture was poured into ice-water and then the formed crystals were filtered off. After washing with water and isopropylether, the crystals was dissloved in ethanol (50 ml) with warming. The solution was concentrated under reduced pressure to give methyl 2-(5-benzoylamino-1,2,4-thiadiazol-3-yl)acetate (1.6 g, 57.7%). m.p.143-144.5C. NMR delta (CDCl3): 3.68(3H,s,--COOOCH3), 3.81(2H,s,CH2), 7.05-8.0(5H,m, --C6 H5) IR(KBr)cm-1: 1720, 1660, 1540. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51.1% | With sodium hydroxide; In water; | 4,4'-di(benzoylthiocarbamoylamino)diphenylamine 4,4'-Diaminodiphenylamine sulfate (1.486 g, 5 mM) was dissolved in 100 ml of water, sodium hydroxide (0.40 g, 10 mM) was added and stirred, and extracted with 150 ml of ethyl acetate. The resulting ethyl acetate solution was thoroughly washed with water, dewatered, and vacuum concentrated to about 20 ml. Precipitated insoluble substances were filtered out, and an ethyl acetate solution of 2 equivalents of benzoylisothiocyanate (1.492 g, 10 mM) was added to the filtrate. The mixture was stirred at room temperature for 30 minutes, the reaction mixture was filtered, and washed with ethyl acetate/n-hexane to obtain 1.60 g (51.1% yield) of a light brown crystal of compound A-22. Melting point: 210 C. 1 H-NMR (DMSO-d6) ppm delta=7.12-8.00 (18H, m, --C6 H4 -- x 2, C6 H5 -- x 2) delta=8.47 (1H, s, --NH--) delta=11.50 (2H, s, --NH-- x 2) delta=12.53 (2H, s, --NH-- x 2) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In hexane; ethyl acetate; acetone; | Step 1) Synthesis of N'-(2-cyanophenyl)-N'-methyl-N''-benzoyl thiourea To a solution of 4.36 g of benzoyl isothiocyanate dissolved in 30 ml of acetone was slowly added a solution of 5.67g of <strong>[17583-40-3]N-methylamino-2-cyanobenzene</strong> dissolved in 40ml of acetone with heating. The reaction solution was distilled under a reduced pressure to remove acetone solvent to obtain residues, which were separated by a column chromatography (using as an eluent a mixture of hexane and ethyl acetate (5:2)) to obtain 2.97g of the title compound. NMR(delta, CDCl3): 8.50(s, 1H), 7.3-7.8(m, 9H), 3.79(s, 3H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 254 4-Methoxy-3-[3-(3-nitro-phenyl)-thioureido]-N-phenyl-benzamide The title compound has been made using the procedure of Example 60, but using 3-amino-4-methoxy-N-phenyl benzamide and benzoyl isothiocyanate as starting materials, which are commercially available from Aldrich; m.p. 217-219 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 67 4-Methoxy-N-phenyl-3-(3-benzoyl-thioureido)-benzamide Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.243 g, 1.0 mmol) and benzoyl isothiocyanate (0.171 g, 1.04 mmol) to afford the product (0.371 g); m.p. 219-222 C. CI Mass Spectrum: [M+H+]+=406. Calculated for C22H19N3O3S: C, 65.17; H, 4.72; N, 10.36. Found: C, 64.98; H, 4.57; N, 10.26. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 6; N-(2-(1H-indol-2-yl)phenyl)-4-tert-butylthiazol-2-amine; 6a. 1-(2-(1H-indol-2-yl)phenyl)thiourea; To a solution of commercially available 2-(1H-indol-2-yl)benzenamine (111 mg, 0.534 mmol) in THF (3.5 mL) was added benzoyl isothiocyanate (79 μL, 0.587 mmol). The reaction was capped and heated at 50 C. with stirring for 2 h. MeOH (1.0 mL) and 2.0M LiOH in water (0.54 mL) was added and the reaction was stirred overnight at 50 C. The reaction was extracted into ethyl acetate (10 mL) and washed with sat. NaCl solution (4 mL). The organic layer was dried over MgSO4, filtered and concentrated. The residue was taken up in dichloromethane (5 mL) and hexane was added slowly to initiate precipitation. Once cloudy appearance observed, addition of hexane was stopped and the reaction was allowed to set for 5-10 min to allow the precipitation to form. Additional hexane was then added (2 mL) and the solid was collected by filtration to provide 6a (103 mg). (M+H)+=268.3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | In acetone; at 20℃; for 0.5h; | To a solution of 5-bromo-2,4-difluoro aniline (1.0 g, 4.81 mmol) in acetone (25.0 ml.) was added drop wise benzoyl isothiocyanate (0.71 mL, 5.29 mmol). The resulting reaction mixture was allowed to stir at room temperature for 30 min. After the completion of the reaction (TLC monitoring), the solvent was evaporated and the residue was washed with hexane and ether to get the title compound (1.70 g, quantitative yield) as a white solid. 1H-NMR (400 MHz, CDCI3): delta 7.02-7.06 (m, 1 H), 7.56 (t, J= 8.0 Hz, 2H), 7.68 (t, J= 7.60 Hz, 1 H), 7.91 (d, J= 7.60 Hz, 2H), 8.67 (t, J= 7.60 Hz, 1 H), 9.15 (br s, 1 H) and 12.65 (br s, 1 H). |
1.70 g | In [(2)H6]acetone; at 20℃; for 0.5h; | To a solution of <strong>[452-92-6]5-bromo-2,4-difluoro-aniline</strong> (1.0 g, 4.81 mmol) in acetone (25.0 mL) was added drop wise benzoyl isothiocyanate (0.71 mL, 5.29 mmol) and the mixture stirred at RT for 30 min. The solvent was evaporated and the residue washed with hexane and Et2O to get i(1.70 g). 1H-NMR (400 MHz, CDCl3): delta 7.02-7.06 (m, 1H), 7.56 (t, J=8.0 Hz, 2H), 7.68 (t, J=7.60 Hz, 1H), 7.91 (d, J=7.60 Hz, 2H), 8.67 (t, J=7.60 Hz, 1H), 9.15 (br s, 1H) and 12.65 (br s, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-thiourea To a solution of commercially available 2,3-dihydro-benzo[1,4]dioxin-5-ylamine (1.00 g, 6.62 mmol) at reflux in acetone (30 mL) was slowly added benzoyl isothiocyanate (0.98 mL, 7.28 mmol). The mixture was stirred at reflux for 50 min and poured into a mixture of ice and water. The resulting precipitate was collected by vacuum filtration and treated with 10% aq. NaOH (15 mL). The mixture was heated to reflux for 1 h and cooled to room temperature. A white solid precipitated and was collected by vacuum filtration, affording the crude title compound which was used without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | In acetone; at 75℃; for 1.5h;Inert atmosphere; | 1-Benzoyl-3-[3-chloro-4-(trifluoromethoxy)phenyl] thiourea To a stirred solution of <strong>[64628-73-5]3-chloro-4-(trifluoromethoxy)aniline</strong> (5.00 g, 23.6 mmol) in acetone (150 mL) under nitrogen was added benzoyl isothiocyanate (3.98 mL, 29.5 mmol). The reaction was heated at 75C for 1.5 h. The cooled reaction mixture was poured into water (400 mL). The resulting precipitate was collected by filtration to give the title compound as a pale orange solid (9.0 g, quantitative yield); m/z = 374.9 (MH)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetone; for 2.0h;Reflux; | General procedure: A solution of acyl chloride (5mmol) and potassium thiocyanate (5.5mmol) in acetone (20mL) was reacted under reflux for 1h. Aromatic amine (5mmol) was added and the mixture was stirred under reflux for 2h. The reaction mixture was cooled to room temperature. The precipitate was filtered, washed with water and recrystallized from ethanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | In acetone; at 20℃; for 1h; | To a solution of <strong>[16618-68-1]3-bromo-5-methoxyaniline</strong> (5.0 g, 25 mmol) stirred in acetone (100 mL) at room temperature, benzoyl isothiocyanate (3.95 mL, 27.2 mmol) was added. The reaction mixture was stirred for 1 hour before the acetone was removed by evaporation. The crude residue obtained was washed with hexanes and collected by filtration to give N-((3-bromo-5-ethoxyphenyl)carbamothioyl)benzamide as a yellow solid (8.0 g, 89 %). LC (Method B): 2.351 min. MS (APCI): calcd for Ci5Hi4BrN202S [M+H]+ m/z 365.0, 367.0, found 365.0, 367.0. 1H NMR (DMSO-d6, 400 MHz) 5 ppm 12.57 (br s, 1H), 11.64 (br s, 1H), 7.98 (d, J = 7.4 Hz, 2H), 7.67 (t, J = 7.4 Hz, 1H), 7.60 (br s, 1H), 7.55 (t, J = 7.8 Hz, 2H), 7.34 (br s, 1H), 7.08 (t, J = 2.0 Hz, 1H), 3.79 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | In acetone; at 20℃; for 3h; | To a solution of <strong>[886372-63-0]5-fluoro-6-methoxypyridin-3-amine</strong> (0.100 g, 0.704 mmol) in acetone (1 mL) was added dropwise benzoyl isothiocyanate (0. 104 mL, 0.774 mmol). The reaction mixture was all owed to stir at room temperature for 3 h. The reaction mixture was diluted with water and EtOAc. The layers were separated and the organic layer was washed with brine, dried with sodium sulfate, and concentrated under reduced pressure to yield Intermediate 1-21 A (0.215 g, 0.704 mmol, 100 % yield): 1H NMR (400MHz, CDCl3) delta 12,48 (brs, 1H), 9.12 (br s, 1 H), 8,06 (d, 2.0 Hz, 1H ). 8.01 (dd, J=10.8, 2,2 Hz, 1H), 7.91 (d, J=1.1Hz, 1 H), 7.89 (d, J = 1 .5 Hz, 1H), 7.71-7.65 (m, 1H), 7.60-7.54 (m, 2H), 4,06 (s, 3H), LC-MS: method H, RT = 1.18 rnin. MS (ESI) m/z: 306.1 (M+H)+. |
100% | In acetone; at 20℃; for 3h; | To a solution of <strong>[886372-63-0]5-fluoro-6-methoxypyridin-3-amine</strong> (0.100 g, 0.704 mmol) in acetone (1 mL) was added dropwise benzoyl isothiocyanate (0.104 mL, 0.774 mmol). The reaction mixture was allowed to stir at room temperature for 3 h. The reaction mixture was diluted with water and EtOAc. The layers were separated and the organiclayer was washed with brine, dried with sodium sulfate, and concentrated under reduced pressure to yield Intermediate I-17A (0.215 g, 0.704 mmol, 100 % yield): ?H NMR (400MHz, CHLOROFORM-d) 12.48 (br. s., 1H), 9.12 (br. s., 1H), 8.06 (d, J2.0 Hz, 1H), 8.01 (dd,J=10.8, 2.2 Hz, 1H), 7.91 (d,J=1.1 Hz, 1H), 7.89 (d,J1.5 Hz, 1H),7.71-7.65 (m, 1H), 7.60-7.54 (m, 2H), 4.06 (s, 3H). LC-MS: method H, RT = 1.18 mm,MS (ESI) m/z: 306.1 (M+H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69.1% | To a solution of <strong>[6635-91-2]6-methoxy-4-methylpyridin-3-amine</strong> (0.150 g, 1.086 mmol) in acetone (1 mL) was added dropwise benzoyl isothiocyanate (0.161 mL, 1.194 mmol). The reaction mixture was allowed to stir at room temperature for 2.5h. The reaction mixture was concentrated under reduced pressure and re-dissolved in tetrahydrofuran (1 mL). To this solution was added sodium methoxide (0.5 M in MeOH) (3.26 mL, 1.628 mmol), and the reaction mixture was allowed to stir at room temperature for 30 mm. The reaction mixture was diluted with water and EtOAc. The layers were separated and the5 organic layer was washed with brine, dried with sodium sulfate, and concentrated under reduced pressure. The reaction mixture was triturated with Et20 and filtered. The solid was collected to yield Intermediate I-16A (0.148 g, 0.750 mmol, 69.1 % yield) as a brown solid. ?H NMR (400MHz, CHLOROFORM-d) 8.04 (s, 1H), 7.54 (br. s., 1H), 6.69 (s, 1H), 6.51-5.18 (m, 2H), 3.93 (s, 3H), 2.28 (s, 3H). LC-MS: method H, RT= 0.93 mm,10 MS (ESI) m/z: 198.1 (M+H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | In acetone; at 50℃; for 16.0h; | To a solution of <strong>[89283-92-1]5-bromo-4-chloropyridin-3-amine</strong> (2.97 g, 14.3 mmol) in acetone(64 mL) was added benzoyl isothiocyanate (4.47 g, 27.4 mmol) at roomtemperature. The resulting mixture was stirred for 16 h at 50°C. When the reactionwas done, the solids were collected by filtration to yield N-[7-bromo-[1 ,3]thiazolo[4,5-c]pyridin-2-yl]benzamide as a yellow solid (3.36 g, 70percent). MS: m/z= 333.8 [M+H]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | In acetone; at 60℃; for 3h; | A solution of commercially available <strong>[7321-93-9]4,6-dichloropyridin-3-amine</strong> (8.0 g, 49.07 mmol) and benzoyl isothiocyanate (7.3 ml_, 53.98 mmol) in acetone (120 ml_) was stirred at 60 C for 3 hours. The reaction was monitored by the TLC. The solvent was evaporated and the solid was filtered, washed with n-hexane (100 ml.) and dried to give the desired product as an off-white solid (14.0 g, 87%). (0683) MS: 328.0 (M+H)+. (0684) 1H-NMR (400 MHz, DMSO- 6) d =12.39 (s, 1 H), 12.02 (s, 1 H), 8.74 (s, 1 H), 7.98-7.99 (m, 3H), 7.67-7.68 (m, 1 H), 7.56 (t, J = 7.60 Hz, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | In acetone; at 20℃; for 3h; | A solution of <strong>[1050501-88-6]2-bromo-6-chloropyridin-3-amine</strong> (30.0 g, 144.46 mmol) and benzoyl isothiocyanate (23.4 ml, 173.52 mmol, 1 .2 eq) in acetone (600 mL, 20 vol) was stirred at room temperature for 3 hours, the reaction was monitored by the TLC. The solvent was evaporated and the solid was filtered and washed with n-hexane (500 mL) and dried to give the desired product as 37.0 g of an off-white solid with 69 % yield. 1H-NMR (500 MHz, CDCI3) d 9.18 (brs, 1 H), 8.84 (d, 1 H), 7.93 (d, 2H), 7.69 (t, 1 H), 7.59-7.56 (m, 2H), 7.37 (d, 1 H). MS (ESI); m/z = 369.8 [M-Hf |
Tags: 532-55-8 synthesis path| 532-55-8 SDS| 532-55-8 COA| 532-55-8 purity| 532-55-8 application| 532-55-8 NMR| 532-55-8 COA| 532-55-8 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
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Code | Phrase |
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P222 | Do not allow contact with air. |
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P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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