4079-54-3|2-Hydroxy-4'-methylacetophenone| Ambeed

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Quality Control of [ 4079-54-3 ] Purity: 98% SDS Specification

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Product Details of [ 4079-54-3 ]

CAS No. :	4079-54-3
Formula :	C₉H₁₀O₂
M.W :	150.17
SMILES Code :	O=C(C1=CC=C(C)C=C1)CO
MDL No. :	MFCD07778990
InChI Key :	BFOWHGYYZRTDOV-UHFFFAOYSA-N
Pubchem ID :	317549

Safety of [ 4079-54-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 4079-54-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 4079-54-3 ]

[ 4079-54-3 ] Synthesis Path-Downstream 1~35

1
[ 65143-37-5 ]
[ 4079-54-3 ]

Yield	Reaction Conditions	Operation in experiment
6 g	With hydrogenchloride; water; In ethanol;Reflux;	General procedure: α-bromo-3’-chloroacetophenone (6a, 17.5 g, 75 mM) in ethanol (100 mL) was refluxed for 10 h with anhydrous sodium acetate (6.2 g, 76 mM). The mixture was diluted with water and the solid which separated was collected and recrystallized from ethyl acetate. Then the solid (2-(3-chlorophenyl)-2-oxoethyl acetate, 10.4 g, 49 mM, 65%) in ethanol (50 mL) and hydrochloric acid (50 mL of 1 M) was refluxed for 6 h. The mixture was diluted with water and was then extracted with ethyl acetate. The extract was dried (sodium sulfate) and concentrated to give 2a (6.8 g, 40 mM, 53%).

References: [1]Journal of Organic Chemistry,2012,vol. 77,p. 5144 - 5148.
[2]Bulletin of the Chemical Society of Japan,1941,vol. 16,p. 252,258.
Bulletin of the Chemical Society of Japan,1943,vol. 18,p. 200.
[3]Chemical Communications,2001,p. 956 - 957.
[4]Tetrahedron Letters,2011,vol. 52,p. 999 - 1002.

2
[ 54731-27-0 ]
[ 4079-54-3 ]

References: [1]Tetrahedron Letters,1982,vol. 23,p. 2917 - 2920.

3
1-(phenylsulfenyl)-2-(p-tolyl)-1,2-bis(trifluoroacetoxy)ethane [ No CAS ]
[ 4079-54-3 ]

References: [1]Tetrahedron Letters,1990,vol. 31,p. 6441 - 6444.
[2]Tetrahedron,1993,vol. 49,p. 11263 - 11304.

4
[ 122-00-9 ]
[ 4079-54-3 ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: To a stirred solutionof the corresponding α-aryl ketones (32 mmol, 1.0 equiv.) and powderedpotassium hydroxide (176 mmol, 5.5 equiv.) in 80 mL methanol was added iodobenzenediacetate (35 mmol, 1.1 equiv) slowly at 0 C. The reaction mixturewas kept at room temperature until TLC indicated the total consumption of the α-arylketones. Then the whole reaction mixture was concentrated. The residue wasshaken with water and ethyl acetate. The combined organic layer was evaporatedunder reduced pressure. The residue was dissolved in a mixture of 20 mL methanoland 20 mL 2 M aqueous hydrochloric acid and then stirred overnight at roomtemperature, and then filtered. The solid was washed with hexanes, and the obtained1-aryl-2-hydroxypropan-1-one 1 wasused directly for the next step without further purifications.1

References: [1]Journal of Chemical Research,2006,p. 32 - 33.
[2]Tetrahedron Letters,1992,vol. 33,p. 6065 - 6068.
[3]European Journal of Organic Chemistry,2016,vol. 2016,p. 5257 - 5262.
[4]Synthetic Communications,2002,vol. 32,p. 1875 - 1879.
[5]Bulletin of the Chemical Society of Japan,1999,vol. 72,p. 2351 - 2356.
[6]Synthesis,2008,p. 3205 - 3208.
[7]Tetrahedron Letters,1981,vol. 22,p. 1283 - 1286.
[8]Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical,1987,vol. 26,p. 475 - 480.
[9]Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical,1987,vol. 26,p. 475 - 480.
[10]Synthetic Communications,1997,vol. 27,p. 4079 - 4084.
[11]Journal of Organic Chemistry,2002,vol. 67,p. 2556 - 2565.
[12]Organic Preparations and Procedures International,2006,vol. 38,p. 473 - 476.
[13]Chemical Communications,2001,p. 956 - 957.
[14]Chemical Communications,2001,p. 956 - 957.
[15]Tetrahedron Letters,1982,vol. 23,p. 2917 - 2920.
[16]Tetrahedron Letters,2016,vol. 57,p. 658 - 662.
[17]Organic and Biomolecular Chemistry,2016,vol. 14,p. 5708 - 5713.
[18]Journal of the American Chemical Society,2016,vol. 138,p. 11093 - 11096.
[19]Advanced Synthesis and Catalysis,2018,vol. 360,p. 744 - 750.
[20]Bioorganic and Medicinal Chemistry Letters,2018,vol. 28,p. 2861 - 2864.
[21]Organic Letters,2018,vol. 20,p. 6033 - 6036.
[22]Chemical Communications,2018,vol. 54,p. 12182 - 12185.
[23]Chemistry - A European Journal,2018,vol. 24,p. 19156 - 19161.
[24]Chemical Communications,2019,vol. 55,p. 4079 - 4082.
[25]Organic Letters,2019,vol. 21,p. 6674 - 6678.
[26]Journal of Organic Chemistry,2019,vol. 84,p. 11945 - 11957.
[27]Journal of the American Chemical Society,2020,vol. 142,p. 9982 - 9992.
[28]Organic Letters,2020,vol. 22,p. 7158 - 7163.
[29]Organic Letters,2021,vol. 23,p. 4715 - 4720.
[30]Green Chemistry,2022,vol. 24,p. 2919 - 2926.
[31]Advanced Synthesis and Catalysis,2022,vol. 364,p. 1757 - 1762.

5
2-methylthio-3-(4-methylphenyl)oxirane [ No CAS ]
[ 4079-54-3 ]

References: [1]Tetrahedron,1995,vol. 51,p. 10593 - 10600.

6
2-(1,5-dithiahexyl)-3-(4-methylphenyl)oxirane [ No CAS ]
[ 4079-54-3 ]

References: [1]Tetrahedron,1995,vol. 51,p. 10593 - 10600.

7
[ 13154-24-0 ]
[ 4079-54-3 ]
1-p-Tolyl-2-triisopropylsilanyloxy-ethanone [ No CAS ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 5280 - 5282.

8
[ 4079-54-3 ]
[ 107-30-2 ]
2-methoxymethoxy-1-p-tolyl-ethanone [ No CAS ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 8100 - 8101.

9
[ 110-87-2 ]
[ 4079-54-3 ]
[ 244031-70-7 ]

References: [1]Tetrahedron Asymmetry,1999,vol. 10,p. 1843 - 1846.
[2]Chemical Communications,2015,vol. 51,p. 4473 - 4476.
[3]Advanced Synthesis and Catalysis,2018,vol. 360,p. 744 - 750.

10
[ 67-56-1 ]
[ 122-00-9 ]
[ 54149-77-8 ]
[ 4079-54-3 ]

References: [1]Bulletin of the Chemical Society of Japan,1999,vol. 72,p. 2351 - 2356.

11
2-halo-4'-methylacetophenone [ No CAS ]
[ 4079-54-3 ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 8100 - 8101.

12
[ 357943-48-7 ]
[ 4079-54-3 ]

References: [1]Chemical Communications,2001,p. 956 - 957.

13
[ 17263-64-8 ]
[ 4079-54-3 ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 5113 - 5116.

14
[ 13107-39-6 ]
[ 4079-54-3 ]

References: [1]Tetrahedron Letters,2002,vol. 43,p. 3237 - 3238.
[2]Journal of Organic Chemistry,2003,vol. 68,p. 9119 - 9121.
[3]Tetrahedron Letters,2005,vol. 46,p. 4111 - 4113.

15
[ 32315-10-9 ]
[ 18328-11-5 ]
[ 4079-54-3 ]
(2S,3R)-2,3-carbonyldioxy-1-(4-methylphenyl)-6-phenyl-1-hexanone [ No CAS ]
(2R,3S)-2,3-carbonyldioxy-1-(4-methylphenyl)-6-phenyl-1-hexanone [ No CAS ]
(2R,3R)-2,3-carbonyldioxy-1-(4-methylphenyl)-6-phenyl-1-hexanone [ No CAS ]

References: [1]Journal of Organic Chemistry,2002,vol. 67,p. 2556 - 2565.

16
[ 4079-54-3 ]
[ 66-25-1 ]
[ 77-76-9 ]
(2S,3R)-2,3-dihydroxy-2,3-O-isopropylidene-1-(4-methylphenyl)-1-octanone [ No CAS ]
(2R,3R)-2,3-dihydroxy-2,3-O-isopropylidene-1-(4-methylphenyl)-1-octanone [ No CAS ]
(2R,3S)-2,3-dihydroxy-2,3-O-isopropylidene-1-(4-methylphenyl)-1-octanone [ No CAS ]

References: [1]Journal of Organic Chemistry,2002,vol. 67,p. 2556 - 2565.

17
[ 18328-11-5 ]
[ 4079-54-3 ]
[ 77-76-9 ]
(2S,3R)-2,3-dihydroxy-2,3-O-isopropylidene-1-(4-methylphenyl)-6-phenyl-1-hexanone [ No CAS ]
(2R,3R)-2,3-dihydroxy-2,3-O-isopropylidene-1-(4-methylphenyl)-6-phenyl-1-hexanone [ No CAS ]
(2R,3S)-2,3-dihydroxy-2,3-O-isopropylidene-1-(4-methylphenyl)-6-phenyl-1-hexanone [ No CAS ]

References: [1]Journal of Organic Chemistry,2002,vol. 67,p. 2556 - 2565.

18
[ 13603-62-8 ]
[ 4079-54-3 ]

Yield	Reaction Conditions	Operation in experiment
89%	With N-Bromosuccinimide; In methanol; water; at 20℃; for 5.5h;Green chemistry;	General procedure: Aromatic alcohol (1-2 mmol) was dissolved in methanol (or acetone in somecases, 2-4 mL) at room temperature, followed by addition of the aqueous solutionof N-bromosuccinimide (1.5 eq.=alcohol) with continuous stirring. GMP-b-CD (3,100mg=mmol of alcohol) were added in the reaction mixture and stirring was continued.Progress of the reaction was monitored by TLC until the reaction was completed(4-6 h). GMP was separated by filtration after completion of the reaction. Thereaction mixture was extracted with ethyl acetate (45 mL), combined organiclayers were dried over Na2SO4, and solvent was removed under reduced pressure.The product was further purified by flash column chromatography and analyzedby NMR spectroscopy.

References: [1]Journal of Organic Chemistry,2003,vol. 68,p. 2058 - 2059.
[2]Advanced Synthesis and Catalysis,2004,vol. 346,p. 346 - 350.
[3]Journal of Chemical Research,2006,p. 188 - 191.
[4]Synthetic Communications,2014,vol. 44,p. 589 - 599.
[5]Tetrahedron Letters,2005,vol. 46,p. 8483 - 8486.
[6]Tetrahedron Letters,2006,vol. 47,p. 8953 - 8957.

19
[ 50-00-0 ]
[ 1218-89-9 ]
[ 4079-54-3 ]
(S)-2-hydroxy-1,2-bis(4-methylphenyl)ethan-1-one [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 6509 - 6512.

20
[ 4079-54-3 ]
(E)-N-(2-methylbenzylidene)-P,P-diphenylphosphinic amide [ No CAS ]
C₂₉H₂₈NO₃P [ No CAS ]
2-hydroxy-1-(4-methylphenyl)-3-(2-methylphenyl)-3-[N-di(2-methylphenyl)phosphinoylamino]-1-propanone [ No CAS ]
C₂₉H₂₈NO₃P [ No CAS ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 8777 - 8785.

21
[ 50-00-0 ]
[ 104-87-0 ]
[ 4079-54-3 ]

References: [1]Tetrahedron,2004,vol. 60,p. 6509 - 6512.
[2]Chemical Communications,2011,vol. 47,p. 573 - 575.
[3]Journal of the American Chemical Society,2016,vol. 138,p. 11970 - 11978.
[4]Angewandte Chemie - International Edition,2019,vol. 58,p. 3903 - 3907.
Angew. Chem.,2019,vol. 131,p. 3943 - 3947,5.
[5]Chemical Communications,2022,vol. 58,p. 4639 - 4642.

22
[ 139016-20-9 ]
[ 1075-47-4 ]
[ 4079-54-3 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 1217 - 1220.

23
[ 4079-54-3 ]
[ 98837-46-8 ]
2-hydroxy-1-(4-methylphenyl)-3-(N-diphenylphosphinoylamino)-3-phenylpropan-1-one [ No CAS ]
2-hydroxy-1-(4-methylphenyl)-3-(N-diphenylphosphinoylamino)-3-phenylpropan-1-one [ No CAS ]
2-hydroxy-1-(4-methylphenyl)-3-(N-diphenylphosphinoylamino)-3-phenylpropan-1-one [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2006,vol. 79,p. 1906 - 1912.

24
[ 4079-54-3 ]
[ 98837-46-8 ]
2-hydroxy-1-(4-methylphenyl)-3-(N-diphenylphosphinoylamino)-3-phenylpropan-1-one [ No CAS ]
2-hydroxy-1-(4-methylphenyl)-3-(N-diphenylphosphinoylamino)-3-phenylpropan-1-one [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2006,vol. 79,p. 1906 - 1912.

25
[ 518068-74-1 ]
[ 4079-54-3 ]

References: [1]Organic Preparations and Procedures International,2006,vol. 38,p. 473 - 476.

26
[ 619-41-0 ]
[ 4079-54-3 ]

Yield	Reaction Conditions	Operation in experiment
53%	With anhydrous sodium formate; In methanol; for 12h;Reflux;	A mixture of 10d (3.0 mmol) and sodium formate (8.0equiv.) in 9 mL MeOH was heated to reflux for 12 h. After the reaction was completed, the mixturewas cool to room temperature, and ethanol was removed in vacuum, diluted with water (10 mL),aqueous layer was extracted with ethyl acetate (3 × 20 mL), and the combined organic phases weredried over Na2SO4, filtered and concentrated. After evaporation, the crude residue was purified bysilica gel column chromatography (200-300 mesh) using petroleum ether and ethyl acetate (15:1, v/v)as eluent to give target compound 15d: Light yellow solid, yield 53%.

References: [1]Advanced Synthesis and Catalysis,2016,vol. 358,p. 74 - 80.
[2]Journal of Organometallic Chemistry,2009,vol. 694,p. 3452 - 3455.
[3]Tetrahedron Letters,2006,vol. 47,p. 9359 - 9364.
[4]Bioorganic and Medicinal Chemistry Letters,2018,vol. 28,p. 2861 - 2864.
[5]Tetrahedron Letters,2011,vol. 52,p. 999 - 1002.
[6]Organic Letters,2014,vol. 16,p. 4400 - 4403.
[7]Chemical Communications,2015,vol. 51,p. 4473 - 4476.
[8]Journal of the American Chemical Society,2016,vol. 138,p. 11093 - 11096.
[9]European Journal of Organic Chemistry,2017,vol. 2017,p. 4434 - 4438.
[10]Advanced Synthesis and Catalysis,2018,vol. 360,p. 1926 - 1931.
[11]Chemical Communications,2018,vol. 54,p. 12182 - 12185.
[12]Chemistry - A European Journal,2018,vol. 24,p. 19156 - 19161.
[13]Organic Letters,2019,vol. 21,p. 6674 - 6678.
[14]Journal of the American Chemical Society,2020,vol. 142,p. 9982 - 9992.
[15]Organic Letters,2020,vol. 22,p. 7158 - 7163.
[16]Organic Letters,2021,vol. 23,p. 4715 - 4720.
[17]Organic Letters,2021,vol. 23,p. 5750 - 5754.
[18]Chemical Communications,2022,vol. 58,p. 2850 - 2853.
[19]Green Chemistry,2022,vol. 24,p. 2919 - 2926.

27
[ 4209-24-9 ]
[ 4079-54-3 ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 9359 - 9364.

28
[ 4079-54-3 ]
[ 139016-20-9 ]
[ 179914-05-7 ]

References: [1]Organic Letters,2007,vol. 9,p. 2564 - 2567.

29
[ 4079-54-3 ]
[ 139016-20-9 ]

Yield	Reaction Conditions	Operation in experiment
86.7%Chromat.	With D-(+)-glucose; NADPH; at 20℃; for 6h;pH 6.5;aq. phosphate buffer;	General procedure: In order to exclude the catalysis of heteroprotein and prove that the reactions were catalyzed by the recombinant protein, we conducted the reduction of ketones by using cell-free extract of E. coli BL21(DE3)/pET-21c and purified enzyme. The reaction mixture in 2 mL comprised 1 mL potassium phosphate buffer (pH 6.5, 0.1 M), 1 mL cell-free extract of E. coli BL21(DE3)/pET-21c (or 5 mg purified enzyme), 10 g/L glucose, NADPH and substrate. The mixture was shaken for 6 h at 20oC. After reaction, mixture was extracted with five volumes of ethyl acetate by vigorous mixing. The organic layer was analyzed by HPLC or GC. The results indicated that the reactions were catalyzed by the purified enzyme and the heteroprotein had no effect on the reactions. (Table 1)
	With bis(1,5-cyclooctadiene)diiridium(I) dichloride; f-amphol; hydrogen; sodium hydroxide; In isopropyl alcohol; at 20℃; under 15201.0 Torr; for 12h;	Under argon atmosphere within the glove box, ligand L24 (Ar=3,5-(tBu)2C6H3) (12.9 mg, 0.0168mmol) and [Ir(COD)Cl]2 (5.4 mg, 0.008mmol) are added into a 2.5 ml vial. After dissolving in iPrOH (1.6 ml), at room temperature complexation for 1h to get the catalyst solution. The catalyst solution (10uL, 0.0001mmol) was added in the 5 ml of hydrogenation vial. Then sequentially add isopropanol solution of NaOH (0.05mmol/mL, 20uL, 0.001mmol), <strong>[4079-54-3]p-methyl-α-hydroxyacetophenone</strong> substrate (0.1mmol), 1 ml isopropanol solvent. Place the hydrogenation vial into the hydrogenation reactor. After replacing with hydrogen three time, place 20atm H2. At room temperature, react for 12h. After completion of reaction the release of hydrogen, the reaction mixture over a short silica gel column. NMR fixed conversion (> 99%), using high performance liquid chromatography (HPLC) assay reaction enantioselectivity ee value (> 99%).

References: [1]Advanced Synthesis and Catalysis,2018,vol. 360,p. 1926 - 1931.
[2]Tetrahedron Asymmetry,1999,vol. 10,p. 1843 - 1846.
[3]Journal of Organic Chemistry,1998,vol. 63,p. 5280 - 5282.
[4]Tetrahedron Letters,2011,vol. 52,p. 999 - 1002.
[5]Patent: CN105732725,2016,A .Location in patent: Paragraph 0115; 0116; 0117.

30
[ 4079-54-3 ]
2-methoxymethoxy-1-p-tolyl-ethanone oxime [ No CAS ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 8100 - 8101.

31
[ 4079-54-3 ]
[ 217650-29-8 ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 8100 - 8101.

32
[ 4079-54-3 ]
N-(2-methoxymethoxy-1-p-tolyl-ethyl)-acetamide [ No CAS ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 8100 - 8101.

33
(+/-)_S-2-(p-tolyl)-1-(phenylsulfinyl)ethene [ No CAS ]
[ 4079-54-3 ]

References: [1]Tetrahedron,1993,vol. 49,p. 11263 - 11304.
[2]Tetrahedron Letters,1990,vol. 31,p. 6441 - 6444.

34
[ 4079-54-3 ]
[ 1795-48-8 ]
isopropyl-carbamic acid 2-oxo-2-p-tolyl-ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
29%	With triethylamine; In dichloromethane; benzene;	(2) A mixture of <strong>[4079-54-3]2-hydroxy-1-p-tolyl-ethanone</strong> (5.6 g, 37 mmol), prepared in the previous step, isopropyl isocyanate (5.5 ml, 56 mmol) and triethylamine (5.16 ml, 37 mmol) in 100 ml of benzene was refluxed under nitrogen for approximately 23 hours. The solvent was removed under reduced pressure. The residue was dissolved in CH2 Cl2 and extracted with 1N HCl. The organic layer was dried (MgSO4) and the solvent removed under reduced pressure to give 8.295 g of an oil. Crystallization of the oil from isopropyl alcohol gave isopropyl-carbamic acid 2-oxo-2-p-tolyl-ethyl ester (2.5267 g, 29%) as a light yellow solid, mp 130-133 C. Elemental Analysis for C13 H17 NO3, Calc'd: C, 66.36; H, 7.28; N, 5.95, Found: C, 66.02; H, 7.39; N, 5.93

References: [1]Patent: US5968975,1999,A .

35
[ 4079-54-3 ]
[ 95-54-5 ]
[ 17286-62-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	With gallium(III) perchlorate; In ethanol; at 25℃;	General procedure: Representative experimental procedure for the synthesis of 2-phenylquinoxaline (3a) (Table 2, entry 1): A mixture of o-phenylenediamine (1a, 0.0541 g, 0.5 mmol), 2-hydroxyaceto-phenone (2a, 0.0681 g, 0.5 mmol) and Ga(ClO4)3 (0.018g, 0.05 mmol) in EtOH (3 mL) was stirred at room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was directly purified by silica gel column chromatography (petroleum ether/ethyl acetate, 10:1) to afford the product 3a. The structures of all products were confirmed by IR, 1H NMR spectroscopy and melting points, which were consistent with literature data.
70%	With triphenylantimony; In toluene; at 20℃; for 3h;	General procedure: Triphenylstibane(35.5 mg, 0.1 mmol, 10 mol%) and diamine 2 (1.2 mmol) were added to a solution of -hydroxy ketone 1(1 mmol) in toluene (6 mL) under air. The solution was stirred at room temperature and monitored byTLC. The reaction mixture was concentrated under reduced pressure and the residue was purified bycolumn chromatography (CH2Cl2) on silica gel. The products were confirmed by comparison of mp,NMR data, and MS spectra with that in the literature. 822:

References: [1]RSC Advances,2016,vol. 6,p. 57154 - 57162.
[2]Tetrahedron Letters,2012,vol. 53,p. 2508 - 2510.
[3]Journal of Organometallic Chemistry,2009,vol. 694,p. 3215 - 3217.
[4]Chemical Communications,2005,p. 1321 - 1323.
[5]Heterocycles,2016,vol. 93,p. 75 - 83.
[6]European Journal of Organic Chemistry,2017,vol. 2017,p. 4434 - 4438.

Historical Records

Technical Information

• Appel Reaction • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chugaev Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Corey-Kim Oxidation • Dess-Martin Oxidation • Fischer Indole Synthesis • Friedel-Crafts Reaction • Grignard Reaction • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Jones Oxidation • Lawesson's Reagent • Leuckart-Wallach Reaction • Martin's Sulfurane Dehydrating Reagent • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mitsunobu Reaction • Moffatt Oxidation • Oxidation of Alcohols by DMSO • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Alcohols • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Alcohols • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Reformatsky Reaction • Ritter Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Sharpless Olefin Synthesis • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Swern Oxidation • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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[ 4079-54-3 ]

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Ketones

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2-Hydroxy-1-phenylethanone

Similarity: 1.00

A102363 [408332-94-5]

1,1'-(1,3-Phenylene)bis(2-hydroxyethanone)

Similarity: 1.00

A555465 [872611-37-5]

1-(2-Acetylphenyl)-2-hydroxyethanone

Similarity: 0.90

A396517 [145070-48-0]

2-Hydroxy-1-(o-tolyl)ethanone

Similarity: 0.90

A277299 [131496-21-4]

2-Hydroxy-1-(naphthalen-1-yl)ethanone

Similarity: 0.90

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 4079-54-3

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