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Chemical Structure| 2368-53-8 Chemical Structure| 2368-53-8

Structure of 2368-53-8

Chemical Structure| 2368-53-8

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Product Details of [ 2368-53-8 ]

CAS No. :2368-53-8
Formula : C6HCl2F3
M.W : 200.97
SMILES Code : FC1=C(Cl)C(F)=C(Cl)C(F)=C1
MDL No. :MFCD00012242
InChI Key :UOGVNYNJSZHQCN-UHFFFAOYSA-N
Pubchem ID :137563

Safety of [ 2368-53-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315-H319
Precautionary Statements:P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501

Application In Synthesis of [ 2368-53-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2368-53-8 ]

[ 2368-53-8 ] Synthesis Path-Downstream   1~35

  • 3
  • [ 13656-36-5 ]
  • [ 2368-53-8 ]
YieldReaction ConditionsOperation in experiment
94% With calcium sulfate polyhydrate; calcium hydroxide; In diethylene glycol; at 120 - 140℃; Diethylene glycol (390 g), calcium hydroxide (20 g) and calcium sulphate hydrate (34g) were added sequentially in a reaction vessel. The reaction mixture was heated to 120-140C. 3,5-Dichloro-2,4,6- trifluorobenzoic acid dissolved in diethylene glycol (1170 g) was added to the reaction mixture at 120-140C. The reaction mass was stirred for additional 1 to 2 hours. The 1,3 -dichloro-2,4,6-trifluorobenzene was recovered by distillation at 150- 180C. (0123) Yield: 94% (0124) Purity: 99.5% (by gas chromatography).
  • 6
  • [ 2368-53-8 ]
  • [ 220987-93-9 ]
YieldReaction ConditionsOperation in experiment
With chlorosulfonic acid; Example A 3,5-Dichloro-2,4,6-trifluorophenylsulfonyl chloride 1,3-Dichloro-2,4,6-trifluorobenzene (5.0 g, 25 mmol) and chlorosulfonic acid (10.0 mL, 150 mmol) were mixed at ambient temperature under a nitrogen atmosphere and the reaction was heated at 80 C. for 24 h. The mixture was then allowed to cool to ambient temperature and was poured onto 12 g of crushed ice. The product was extracted with diethyl ether, dried over MgSO4, and the solvent was evaporated to produce 4.9 g of the title compound, which was used without further purification. MS(EI): 300 (30, M+), 298 (28), 263 (100), 199 (80).
With chlorosulfonic acid; Example B 3,5-Dichloro-2,4,6-trifluorophenylsulfonyl Chloride. 1,3-Dichloro-2,4,6-trifluorobenzene (5.0 g, 25 mmol) and chlorosulfonic acid (10.0 ml, 150 mmol) were mixed at ambient temperature under a nitrogen atmosphere and the reaction was heated at 80 C. for 24 h. The mixture was then allowed to cool to ambient temperature and was poured onto 12 g of crushed ice. The product was extracted with diethyl ether, dried over MgSO4, and evaporated to produce 4.9 g of the title compound, which was used without further purification. MS (EI): 300 (30, M+), 298 (28), 263 (100), 199 (80).
  • 9
  • [ 1521-51-3 ]
  • [ 213135-39-8 ]
  • [ 2368-53-8 ]
  • 1,3-dichloro-5-cyclohex-2-enyl-2,4,6-trifluoro-benzene [ No CAS ]
  • 10
  • [Pd2(μ-C6Cl2F3)2(5-C6F5-1,2-η3-cyclohexenyl)2] [ No CAS ]
  • [ 784-14-5 ]
  • [ 2368-53-8 ]
  • 1-cyclohex-3-enyl-2,3,4,5,6-pentafluoro-benzene [ No CAS ]
  • 11
  • [Pd(5-C6F5-η3-cyclohexenyl)(C6Cl2F3)(NCMe)] [ No CAS ]
  • [ 784-14-5 ]
  • [ 2368-53-8 ]
  • 1-cyclohex-3-enyl-2,3,4,5,6-pentafluoro-benzene [ No CAS ]
  • 12
  • [ 2368-53-8 ]
  • [ 3743-86-0 ]
  • [ 2369-29-1 ]
  • 2-chloro-5-fluoro-1,3-phenylenediamine [ No CAS ]
  • 13
  • [ 319-88-0 ]
  • [ 2368-53-8 ]
  • 20
  • C6Cl2F3NO2 [ No CAS ]
  • [ 2368-53-8 ]
  • 21
  • C6H2Cl2F3N [ No CAS ]
  • [ 2368-53-8 ]
YieldReaction ConditionsOperation in experiment
With phosphinic acid; In ethanol; at 20℃; for 12h; Step four, the three steps of the pure product or 10M after the product was concentrated, 10M hypophosphorous acid (or 8M, 12M, 15M, 20M, 30M range, is replaced or phosphorous acid or hypophosphorous acid is an acid salt / time phosphoric acid or a salt thereof) or 10M ethanol (or 20M, 30M, 40M, 50M, 60M range) into the reaction kettle and mixed well;Step five, kept at room temperature for 12 hours.
  • 22
  • [ 82-68-8 ]
  • [ 2368-53-8 ]
  • 23
  • [ 2368-53-8 ]
  • [ 31612-68-7 ]
YieldReaction ConditionsOperation in experiment
2987 g With potassium iodide; at 20℃; for 12h;Large scale; Step six, the 10M of KI (or 15M, 20M, 30M of KI, NaI, ICl, I2, KI3 or NaI3) into reactor, kept at room temperature for 12 hours;Step eight, after completion of the reaction was cooled to room temperature, washed with sodium nitrate acidic pH adjusted to 4-5 system, via at least once washed, acid-base refining and / or ethanol recrystallization process to obtain 2987g of product.
  • 24
  • [ 2368-53-8 ]
  • [ 2367-76-2 ]
  • 25
  • [ 2368-53-8 ]
  • [ 28314-80-9 ]
  • 26
  • [ 2368-53-8 ]
  • [ 372-38-3 ]
YieldReaction ConditionsOperation in experiment
85% With dipotassium hydrogenphosphate; palladium 10% on activated carbon; hydrogen; In water; at 140℃; under 11251.1 Torr; l,3-Dichloro-2,4,6-trifluorobenzene (100 g), water (500 g), dipotassium hydrogen phosphate (260 g) and Palladium/carbon (10%; 2 g) were taken in a reaction vessel. Reaction vessel was flushed first with nitrogen and then with hydrogen. The reaction mixture was heated to 140C. Hydrogen gas was purged continuously into the reaction vessel at 140C and 15 kg/centimeter2 pressure. Progress of the reaction was monitored by gas chromatography. After completion of the reaction, reaction mass was cooled to 10-15C and excess hydrogen pressure was released. 1,3,5- trifluorobenzene was recovered from the reaction mass. The bottom mass containing Pd/ C was filtered, washed with fresh water and recycled in next batch. Yield: 85% (0126) Purity: 99.6% (gas chromatography).
  • 27
  • [ 2368-53-8 ]
  • [ 1126-00-7 ]
  • C15H7Cl2F3N2 [ No CAS ]
  • 28
  • [ 2368-53-8 ]
  • C6(2)HCl2F3 [ No CAS ]
  • 29
  • [ 2368-53-8 ]
  • C15H7Cl2F3N2 [ No CAS ]
  • 30
  • [ 2368-53-8 ]
  • 3,6-di-methoxy-9H-carbazole [ No CAS ]
  • C20H13Cl2F2NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% With caesium carbonate; In N,N-dimethyl-formamide; at 130℃; for 3h;Inert atmosphere; In an argon atmosphere,Add 25-1 (10.0g, 0.050mol) into a 500mL three-necked flask,3,6-Dimethoxycarbazole (11.4g, 0.050 mol)And cesium carbonate (57.5g, 0.13mol),Take 210mL of N,N-dimethylformamide (DMF) into the bottle,Warm up to 130C, stir and react for 3 hours,After cooling to room temperature, the reaction solution was added to 400 mL of saturated brine to settle,Filter, vacuum dry,The obtained solid was separated by a silica gel column to obtain product 25-2 (14.7 g, yield: 72%).
  • 31
  • [ 2368-53-8 ]
  • N,N,N',N'-tetrakis(4-t-butylphenyl)-9H-carbazole-3,6-diamine [ No CAS ]
  • C58H59Cl2F2N3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With caesium carbonate; In N,N-dimethyl-formamide; at 130℃; for 3h;Inert atmosphere; In an argon atmosphere,Add 25-1 (10.0g, 0.050mol) into a 500mL three-necked flask,N3,N3,N6,N6-tetrakis(4-tert-butylphenyl)-9H-carbazole-3,6-diamine (36.3g, 0.050mol)And cesium carbonate (57.5g, 0.13mol), take 250mL of N,N-dimethylformamide (DMF) into the bottle, heat to 130, stir and react for 3 hours, cool to room temperature, add 400mL saturated Settling in brine, filtering, and vacuum drying, the obtained solid was separated by silica gel column to obtain product 26-1 (29.5 g, yield: 65%).
  • 32
  • [ 2368-53-8 ]
  • [ 194-59-2 ]
  • C26H13Cl2F2N [ No CAS ]
YieldReaction ConditionsOperation in experiment
66% With caesium carbonate; In N,N-dimethyl-formamide; at 130℃; for 3h;Inert atmosphere; In an argon atmosphere,Add 25-1 (10.0g, 0.050mol) into a 500mL three-necked flask,7H-Dibenzocarbazole (13.4g, 0.050 mol) and cesium carbonate (57.5g, 0.13mol),Take 230mL of N,N-dimethylformamide (DMF) into the bottle,Warm up to 130C, stir and react for 3 hours,After cooling to room temperature, the reaction solution was added to 400 mL of saturated brine to settle,Filter, vacuum dry,The obtained solid was separated by a silica gel column to obtain product 28-1 (14.8 g, yield: 66%).
  • 33
  • [ 2368-53-8 ]
  • C32H23Cl2NO2Se2 [ No CAS ]
  • 34
  • [ 2368-53-8 ]
  • C32H19B2NO2Se2 [ No CAS ]
  • 35
  • [ 2368-53-8 ]
  • C46H39Cl2NSe2 [ No CAS ]
 

Historical Records

Technical Information

• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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