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CAS No. : | 2293-07-4 |
Formula : | C8H10N2OS |
M.W : | 182.24 |
SMILES Code : | S=C(N)NC1=CC=C(OC)C=C1 |
MDL No. : | MFCD00004936 |
Boiling Point : | No data available |
InChI Key : | SRYLJBWDZZMDSK-UHFFFAOYSA-N |
Pubchem ID : | 667549 |
GHS Pictogram: | ![]() |
Signal Word: | Danger |
Hazard Statements: | H301 |
Precautionary Statements: | P301+P310 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In tetrahydrofuran; water; at 100℃; for 1h; | General procedure: A solution of N-aryl-N'-benzoylthiourea (D) in aqueous sodium hydroxide (2 M)/THF (1:1) was heated to 100 C for 1 h. The precipitating solid N-substituted thiourea (E) was collected and washed with H2O.30 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In water; at 80℃; | General procedure: Substituted aniline’s (1 g, 0.0107 mmol) and potassiumthiocyante (4.17 g, 0.043 mmol) were dissolved in 10 mlof conc.HCl and the mixture was refluxed for overnight at80 C. The completion of the reaction was monitored byTLC. The solid formed was filtered, dried and recrystallizedusing ethanol to obtain the required thiourea with 78-80%yield (Hantzsch and Weber 1887). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of 3.0 g (15 mmol) 4-(2-bromo)acetylpyridine (6-2) in 50 mL water was added an equimolar amount of 4-methoxyphenylthiourea (7-1; 2.75 g). The reaction was diluted with 20 mL EtOH. The reaction was allowed to stir at rt overnight, over which time a color change occurred from clear to a thick orange precipitate. The reaction mixture was diluted with 100 mL water then the pH was adjusted to neutral with 1N NaOH. The reaction was allowed to stir at rt and a large amount of precipitate formed which was collected by filtration. The resulting powder was dried under high vacuum to yield N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine (7-2): 1H NMR (500 MHz, CD3OD) δ 8.98 (d, J=3 Hz, 2H), 8.10 (d, J=3 Hz, 2H), 7.53 (s, 1H), 3.0 (s, 3H): MS 284.3 found 284.2 (M+H+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | In N,N-dimethyl-formamide; at 20℃; for 49h;Heating / reflux; | A mixture of 10 (11.66 g, 55 mmol) and 11 (10 g, 55 mmol) in DMF (30 ml) was heated to reflux for 1 h allowed to stand at RT for 48 h. A solid formed which was collected by filtration and washed with ethanol and hexane to give 12 (10.4 g, 52%) as a white solid. Mass spec: m/z 359 (MH+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30% | In ethanol; | There was thus obtained 2-amino-1-cyclohexyl-1,4-dihydro-6 -methyl-4-pyrimidinone hydrochloride (0.98 g, 30% based on thioxo compound), m.p. 225-226 C., with a satisfactory microanalysis. The starting material for Ex. 7 was prepared as follows: N-(4-Methoxyphenyl)thiourea (18.2 g, 100 mM) and 2,6,6-trimethyl-1,3-dioxin-4-one (21.3 g, 150 mM) were heated together at 140 C. (bath temperature) for 30 minutes. The solid product was cooled, treated with ethanol (100 ml), boiled for 10 minutes, cooled and the solid product was isolated by filtration. More dioxinone (21.3 g) was added to the above material and the mixture was heated at 140 C. for a further 20 minutes. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; | EXAMPLE 1 738 Parts of p-anisidine, 502 parts of ammonium rhodanide and 78 parts of a 40% aqueous sodium bisulfate solution are introduced successively, while stirring, into 1050 parts of 20% aqueous hydrochloric acid. This mixture is heated to 95 to 100 C. and stirred for 12 to 15 hours at this temperature. Thereafter the precipitate having been formed is filtered off with suction, while hot, washed with hot water until neutral and dried. 1038 Parts (corresponding to 95.1% of the theory) of 4-methoxyphenyl thiourea of the formula STR3 are obtained, the compound having a melting point of from 200 to 201 C. If the ammonium rhodanide is replaced by an equivalent amount of sodium or potassium rhodanide, the 4-methoxyphenyl thiourea is obtained in an equally high yield and quality. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | In neat (no solvent); for 0.0833333h;Microwave irradiation; Heating; | General procedure: Microwave method: Equimolar quantities of 4-(bromomethyl)pyridinehydrobromide (2 mmol) and substituted N-phenylthiourea (2mmol) are mixed and MW irradiated at 120 C with a power of 300 W foran optimal reaction time. After the reaction was completed, the crudemixture was cooled to 50 C before being suspended in water andalkalinized with NH4OH. To get the desired thiazole derivatives (3a-g),the precipitate was filtered and recrystallized from ethanol. |
60% | [0244] 7V-(4-Methoxyphenyl)-4-(4-pyridinyl)-l,3-thiazol-2-amine (27). A mixture of bromoketone hydrobromide 1 (1.26 g, 4.50 mmol) and 4- methoxyphenylthiourea (26) (0.82 g, 4.50 mmol) in EtOH (20 mL) was stirred at reflux temperature for 1 h. The mixture was cooled to 20 0C, diluted with water (50 mL), the pH adjusted to ca. 8 with aqueous NH3 and the mixture stirred at 5 0C for 2 h. The precipitate was filtered, washed with water (5 mL) and dried. The crude solid was purified by column chromatography, eluting with EtOAc, to give amine 27 (0.76 g, 60%) as a cream powder: mp (EtOAc) 178-180 0C; 1H NMR δ 10.13 (br s, 1 H, NH), 8.61 (dd, J= 4.5, 1.6 Hz, 2 H, H-2', H-6'), 7.83 (dd, J= 4.5, 1.6 Hz, 2 H, H-3', H-5'), 7.60 (m, 3 H, H-5, H-3", H-5"), 6.95 (ddd, J= 6.8, 3.5, 2.2 Hz, 2 H, H-2", H-6"), 3.74 (s, 3 H, OCH3); 13C NMR δ 164.1, 154.2, 150.0 (2), 147.6, 141.0, 134.4, 119.8 (2), 118.7 (2), 114.2 (2), 106.6, 55.1; MS m/z 284.5 (MH+, 100%). Anal, calcd for Ci5Hi3N3OS: C, 63.58; H, 4.62; N, 14.83. Found: C, 63.45; H, 4.65; N, 14.82%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonium hydroxide; copper(ll) bromide; In water; ethyl acetate; at 25℃; for 3h; | To a stirred mixture of solvent (6 mL), aqueous ammonia(2.2 mmol, 25%) and dithiocarbamic acid salt 1 (1 mmol), CuBr2 (0.5 mmol) was added slowly, and the reaction mixture was stirred at room temperature for 3 h, thioureas (2) were generated in situ. During this period, a black precipitate was observed and settled at the bottom of the roundbottom flask. The reaction mixture was transferred into centrifuged tubes and the mixture was centrifuged for 10 min by using a centrifugation machine. The black solid settled in the bottom of the centrifuge tubes. Excess ammonia was removed by heating the reaction mixture on a hot-waterbath (50 C) for 10 min. Then CuBr2 (2.2 mmol) and ketone (3, 1.1 mmol) was added and continue reflux. The progress of the reaction was investigated by TLC (2% ethyl acetate in hexane). After finishing the reaction, the reaction mixture was filtered at 50 C and the filter was extracted with ethylacetate (220 mL). The ethyl acetate layer was washed witha saturated solution of NaHCO3 (5 mL), dried over anhydrous Na2SO4, concentrated under reduced pressure, and purified over a silica-gel column (hexane - EtOAc, 9:1:) to give 2-Aminothiazoles 4a-4m. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With carbon tetrabromide; triethylamine; In acetonitrile; at 20℃; for 2h; | General procedure: To a mixture of ketone (0.5 mmol), thiourea (0.5 mmol), and triethylamine (0.5 mmol) in acetonitrile (3 mL) was added carbon tetrabromide (0.5 mmol) in a round bottom flask at room temperature and the reaction mixture was stirred for 2-6 h. After completion of the reaction (monitored by TLC), water (5 mL) was added and the mixture was extracted with EtOAc (3*5 mL). The combined organic phase was dried over MgSO4, filtered, and evaporated under reduced pressure to give the crude product. The resulting product was purified by silica gel column chromatography using a gradient mixture of hexane/ethyl acetate as eluent to afford an analytically pure sample of 3. |
With copper(ll) bromide; In water; ethyl acetate; for 3h;Reflux; | To a stirred mixture of solvent (6 mL), aqueous ammonia(2.2 mmol, 25%) and dithiocarbamic acid salt 1 (1 mmol), CuBr2 (0.5 mmol) was added slowly, and the reaction mixture was stirred at room temperature for 3 h, thioureas (2) were generated in situ. During this period, a black precipitate was observed and settled at the bottom of the roundbottom flask. The reaction mixture was transferred into centrifuged tubes and the mixture was centrifuged for 10 min by using a centrifugation machine. The black solid settled in the bottom of the centrifuge tubes. Excess ammonia was removed by heating the reaction mixture on a hot-waterbath (50 C) for 10 min. Then CuBr2 (2.2 mmol) and ketone (3, 1.1 mmol) was added and continue reflux. The progress of the reaction was investigated by TLC (2% ethyl acetate in hexane). After finishing the reaction, the reaction mixture was filtered at 50 C and the filter was extracted with ethylacetate (220 mL). The ethyl acetate layer was washed witha saturated solution of NaHCO3 (5 mL), dried over anhydrous Na2SO4, concentrated under reduced pressure, and purified over a silica-gel column (hexane - EtOAc, 9:1:) to give 2-Aminothiazoles 4a-4m. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; water; potassium hydroxide; In acetonitrile; at 20℃; for 0.166667h; | To a stirred solution of phenylthiourea 1 (1mmol) and 5% aq. KOH (5 mL) in acetonitrile (5 mL) was added DHPDMDO (0.332 g, 2mmol). The resulting mixture was allowed to stir at room temperature for an appropriate time (Table 2). After completion of the reaction as monitored by TLC, the reaction mixture was diluted with water (10mL) and the product was extracted in dichloromethan (3×5mL). The combined organic layer was washed with water (2×5mL) and dried over anhydrous Na2SO4. Evaporation of the solvent under reduced pressure gave almost pure products. Structures of the known products were established on the basis of their physical and spectroscopic (IR, 1H-NMR and 13C-NMR) data, which were consistent with those reported.[34,61] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
49% | In ethanol; for 15h;Reflux; | General procedure: A mixture of 3-bromocyclohexane-1,2-dione 3 (50 mg, 0.26 mmol) and pyridine-4-carbothioamide (24.1 mg, 0.17 mmol) in EtOH (0.69 mL) was heated to reflux and stirred for 15 h. The reaction mixture was diluted with DMSO (0.5 mL) to completely dissolve all solids and the resulting mixture was purified by directly injecting the reaction mixture into a preparatory HPLC (C18, water/acetonitrile/ammonium acetate buffer) to give 2-(pyridin-4-yl)-6,7-dihydrobenzo[d]thiazol-4(5H)-one (30.4 mg, 0.13 mmol, 76%) (Table 1, entry 1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example B20Preparation of Compound 102; Sulfuryl chloride (0.0055 mol) was added dropwise to a solution of 3-oxo-hexanoic acid, ethyl ester (0.0055 mol) in CH2Cl2 (q.s.). The reaction mixture was stirred for 2 hours at room temperature. The solvent was evaporated. A solution of (4-methoxyphenyl)-thiourea (0.0055 mol) in EtOH (100 ml) was added to the residue. The resultant reaction mixture was stirred and refluxed for 4 hours. A saturated aqueous NaHCO3 solution was added. This mixture was extracted with EtOAc. The separated organic layer was purified by column chromatography over silica gel. The product fractions were collected and the solvent was evaporated, yielding compound 102. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54% | Example B22Preparation of compound 104; β-Oxo-1-[(phenylmethoxy)carbonyl]-3-piperidinepropanoic acid, ethyl ester (0.0033 mol) and sulfuryl chloride (0.0036 mol) were dissolved in CH2Cl2 (10 ml). The reaction mixture was stirred for 2 hours. The solvent was evaporated in vacuo. This residue and (4-methoxyphenyl)-thiourea (0.0030 mol) were dissolved in EtOH (10 ml) and the resultant reaction mixture was stirred and refluxed for 4 hours, then cooled to room temperature. The mixture was filtered and the filter residue was washed with EtOH (10 ml), then stirred in a saturated aqueous NaHCO3 solution, then filtered off and dried in vacuo, yielding 0.8 g (54%) of compound 104. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
24% | e) Preparation of Intermediate 37; A mixture of intermediate 36 (0.00018 mol) and N,N,N-tributyl-1-butanaminium (tribromide) (0.00078 mol) in THF (20 ml) was refluxed for 2 hours. The solvent was evaporated. (4-Methoxyphenyl)-thiourea (0.00117 mol) and EtOH (20 ml) were added to the residue and then refluxed for 2 hours. The solvent was evaporated. The residue was partitioned between NaHCO3 saturated aqueous solution and EtOAc. The separated organic layer's solvent was evaporated. The residue was purified by TLC (eluens: petroleum ether/EtOAc 2:1), yielding 0.080 g (24%) of intermediate 37. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With triethylamine; In ethanol;Reflux; | 25 mL solanes were added with 1 mmol of N-(4-methoxyphenyl) thiourea.1.05 mmol alpha-bromoacetophenone,10 mL of ethanol was added to dissolve, and then 1.5 mmoL of triethylamine was added and refluxed.After TLC tracks the reaction,The temperature of the reaction solution was lowered to room temperature, and the solvent was distilled off under reduced pressure.Column chromatography of the residue (eluent: petroleum ether-ethyl acetate) yields the target compound,It is a white solid with a yield of 76%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 110℃; for 0.166667h;Microwave irradiation; | General procedure: 2-Bromo-1-(4-methoxyphenyl)ethanone 7 (0.437 mmol, 100 mg) and N-(4-phenoxyphenyl)thiourea 8 (0.437 mmol, 107 mg) were suspended in ethanol (2 mL) and subjected to microwave irradiation at 110C for 10 min. The resulting solution was diluted with CH2Cl2 (10 mL) and washed with a saturated aqueous solution of Na2CO3 (20 mL). The organic layer was dried (MgSO4) and evaporated under reduced pressure. The resulting crude residue was purified by silica gel column chromatography (EtOAc-hexanes, gradient) using a ISCO system to give aminothiazole 2e as a light orange solid (0.246 mmol, 92 mg, 56%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 110℃; for 0.166667h;Microwave irradiation; | General procedure: 2-Bromo-1-(4-methoxyphenyl)ethanone 7 (0.437 mmol, 100 mg) and N-(4-phenoxyphenyl)thiourea 8 (0.437 mmol, 107 mg) were suspended in ethanol (2 mL) and subjected to microwave irradiation at 110C for 10 min. The resulting solution was diluted with CH2Cl2 (10 mL) and washed with a saturated aqueous solution of Na2CO3 (20 mL). The organic layer was dried (MgSO4) and evaporated under reduced pressure. The resulting crude residue was purified by silica gel column chromatography (EtOAc-hexanes, gradient) using a ISCO system to give aminothiazole 2e as a light orange solid (0.246 mmol, 92 mg, 56%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 110℃; for 0.166667h;Microwave irradiation; | General procedure: 2-Bromo-1-(4-methoxyphenyl)ethanone 7 (0.437 mmol, 100 mg) and N-(4-phenoxyphenyl)thiourea 8 (0.437 mmol, 107 mg) were suspended in ethanol (2 mL) and subjected to microwave irradiation at 110C for 10 min. The resulting solution was diluted with CH2Cl2 (10 mL) and washed with a saturated aqueous solution of Na2CO3 (20 mL). The organic layer was dried (MgSO4) and evaporated under reduced pressure. The resulting crude residue was purified by silica gel column chromatography (EtOAc-hexanes, gradient) using a ISCO system to give aminothiazole 2e as a light orange solid (0.246 mmol, 92 mg, 56%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 110℃; for 0.166667h;Microwave irradiation; | General procedure: 2-Bromo-1-(4-methoxyphenyl)ethanone 7 (0.437 mmol, 100 mg) and N-(4-phenoxyphenyl)thiourea 8 (0.437 mmol, 107 mg) were suspended in ethanol (2 mL) and subjected to microwave irradiation at 110C for 10 min. The resulting solution was diluted with CH2Cl2 (10 mL) and washed with a saturated aqueous solution of Na2CO3 (20 mL). The organic layer was dried (MgSO4) and evaporated under reduced pressure. The resulting crude residue was purified by silica gel column chromatography (EtOAc-hexanes, gradient) using a ISCO system to give aminothiazole 2e as a light orange solid (0.246 mmol, 92 mg, 56%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 110℃; for 0.166667h;Microwave irradiation; | General procedure: 2-Bromo-1-(4-methoxyphenyl)ethanone 7 (0.437 mmol, 100 mg) and N-(4-phenoxyphenyl)thiourea 8 (0.437 mmol, 107 mg) were suspended in ethanol (2 mL) and subjected to microwave irradiation at 110C for 10 min. The resulting solution was diluted with CH2Cl2 (10 mL) and washed with a saturated aqueous solution of Na2CO3 (20 mL). The organic layer was dried (MgSO4) and evaporated under reduced pressure. The resulting crude residue was purified by silica gel column chromatography (EtOAc-hexanes, gradient) using a ISCO system to give aminothiazole 2e as a light orange solid (0.246 mmol, 92 mg, 56%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 110℃; for 0.166667h;Microwave irradiation; | General procedure: 2-Bromo-1-(4-methoxyphenyl)ethanone 7 (0.437 mmol, 100 mg) and N-(4-phenoxyphenyl)thiourea 8 (0.437 mmol, 107 mg) were suspended in ethanol (2 mL) and subjected to microwave irradiation at 110C for 10 min. The resulting solution was diluted with CH2Cl2 (10 mL) and washed with a saturated aqueous solution of Na2CO3 (20 mL). The organic layer was dried (MgSO4) and evaporated under reduced pressure. The resulting crude residue was purified by silica gel column chromatography (EtOAc-hexanes, gradient) using a ISCO system to give aminothiazole 2e as a light orange solid (0.246 mmol, 92 mg, 56%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | In methanol; at 90℃; under 12929.0 Torr; for 0.5h;Microwave irradiation; | General procedure: 2-Chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanone (4a, 0.272g, 0.098 mmol) and 1-phenylthiourea (5a, 0.100g, 0.06 mmol) were mixed properly and was charged into a specially designed MW test tube and methanol (2 mL) was added to this mixture and was irradiated for 30 min at 90 oC and 250 psi pressure. After cooling, the solid mass was crushed into 20 ml methanol to stirred for 15 mins to dissolve unreacted starting materials. The solid mass was filtered and the filtrate was discarded. After washing several time with cold ethanol, the solid mass was dried under vacuum to get the N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amine, 6a). The related compounds (6b-p) were prepared in the same way |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | In methanol; at 90℃; under 12929.0 Torr; for 0.5h;Microwave irradiation; | General procedure: 2-Chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanone (4a, 0.272g, 0.098 mmol) and 1-phenylthiourea (5a, 0.100g, 0.06 mmol) were mixed properly and was charged into a specially designed MW test tube and methanol (2 mL) was added to this mixture and was irradiated for 30 min at 90 oC and 250 psi pressure. After cooling, the solid mass was crushed into 20 ml methanol to stirred for 15 mins to dissolve unreacted starting materials. The solid mass was filtered and the filtrate was discarded. After washing several time with cold ethanol, the solid mass was dried under vacuum to get the N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amine, 6a). The related compounds (6b-p) were prepared in the same way |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | In methanol; at 90℃; under 12929.0 Torr; for 0.5h;Microwave irradiation; | General procedure: 2-Chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanone (4a, 0.272g, 0.098 mmol) and 1-phenylthiourea (5a, 0.100g, 0.06 mmol) were mixed properly and was charged into a specially designed MW test tube and methanol (2 mL) was added to this mixture and was irradiated for 30 min at 90 oC and 250 psi pressure. After cooling, the solid mass was crushed into 20 ml methanol to stirred for 15 mins to dissolve unreacted starting materials. The solid mass was filtered and the filtrate was discarded. After washing several time with cold ethanol, the solid mass was dried under vacuum to get the N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amine, 6a). The related compounds (6b-p) were prepared in the same way |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 20℃; for 0.0833333h; | General procedure: A mixture of equimolar quantities of the earlier synthesizedthiourea (1 g, 0.0059 mmol) and substituted phenacyl bromide(1.17 g, 0.0059 mmol) were taken in ethanol andstirred for 2-5 min. The progress of the reaction wasmonitored by TLC and the solid separated was filtered,washed with cold ethanol, dried and recrystallized fromethanol to get N,4-diphenylthiazol-2-amine in good yields(Bikobo et al. 2017; Dighe et al. 2011). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 20℃; for 0.0833333h; | General procedure: A mixture of equimolar quantities of the earlier synthesizedthiourea (1 g, 0.0059 mmol) and substituted phenacyl bromide(1.17 g, 0.0059 mmol) were taken in ethanol andstirred for 2-5 min. The progress of the reaction wasmonitored by TLC and the solid separated was filtered,washed with cold ethanol, dried and recrystallized fromethanol to get N,4-diphenylthiazol-2-amine in good yields(Bikobo et al. 2017; Dighe et al. 2011). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | In tetrahydrofuran; at 30℃; for 0.75h; | N-(2,5-dimethoxyphenyl)-4-(4-methoxyphenyl)thiazol-2-amine (7c) The reaction of the l-(4-methoxyphenyl)thiourea (365mg, 2mM) and freshly synthesized 2- bromo-l-(2,5-dimethoxyphenyl)ethanone (520mg, 2mM) in anhydrous THF at 30C for 45 mins resulted in the formation of suspension, which was filtered and dried to yield the final product (74% yield). mp 104C. MS: m/z 343 (M + 1)+. |
Tags: 2293-07-4 synthesis path| 2293-07-4 SDS| 2293-07-4 COA| 2293-07-4 purity| 2293-07-4 application| 2293-07-4 NMR| 2293-07-4 COA| 2293-07-4 structure
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P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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