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Chemical Structure| 6221-13-2 Chemical Structure| 6221-13-2

Structure of 6221-13-2

Chemical Structure| 6221-13-2

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Product Details of [ 6221-13-2 ]

CAS No. :6221-13-2
Formula : C7H6BrNO
M.W : 200.03
SMILES Code : BrCC(=O)C1=CC=NC=C1
MDL No. :MFCD06253791

Safety of [ 6221-13-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H290
Precautionary Statements:P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 6221-13-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6221-13-2 ]

[ 6221-13-2 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 6221-13-2 ]
  • [ 17356-08-0 ]
  • [ 30235-28-0 ]
YieldReaction ConditionsOperation in experiment
General procedure: To a solution of 2 (11.2 mmol) in 25 ml of ethanol at room temperature was added thiourea (13.4 mmol).The reaction mixture was stirred at room temperature for 1 hour, quenched with water and washed with dichloromethane. The aqueous phase was concentrated in vacuo to give a yellow solid HBr salt. The salt was then dissolved in minimal amount of water and 10% NaOH added drop wise until a white precipitate 3 formed (approximately at pH 8).The precipitate was then filtered and dried.
  • 2
  • [ 6221-13-2 ]
  • [ 2293-07-4 ]
  • [ 61889-63-2 ]
YieldReaction ConditionsOperation in experiment
To a solution of 3.0 g (15 mmol) 4-(2-bromo)acetylpyridine (6-2) in 50 mL water was added an equimolar amount of 4-methoxyphenylthiourea (7-1; 2.75 g). The reaction was diluted with 20 mL EtOH. The reaction was allowed to stir at rt overnight, over which time a color change occurred from clear to a thick orange precipitate. The reaction mixture was diluted with 100 mL water then the pH was adjusted to neutral with 1N NaOH. The reaction was allowed to stir at rt and a large amount of precipitate formed which was collected by filtration. The resulting powder was dried under high vacuum to yield N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine (7-2): 1H NMR (500 MHz, CD3OD) δ 8.98 (d, J=3 Hz, 2H), 8.10 (d, J=3 Hz, 2H), 7.53 (s, 1H), 3.0 (s, 3H): MS 284.3 found 284.2 (M+H+).
  • 3
  • [ 6221-13-2 ]
  • [ 30235-28-0 ]
YieldReaction ConditionsOperation in experiment
410 mg (65%) (B) 4-(4-Pyridyl)-1,3-thiazol-2-amine Reactions were performed in the same manner as in Example 8, (A) by using 2-bromo-1-(4-pyridyl)-1-ethanone (1 g, 3.56 mmol) to obtain 410 mg (65%) of the title compound. 1H-NMR (CD3OD) delta:7.26 (1H, s), 7.80 (2H, d, J=6.35 Hz), 8.50 (2H, d, J=6.35 Hz) EI/MS; m/z: 176 (M+-1)
  • 4
  • [ 6221-13-2 ]
  • [ 107707-33-5 ]
  • N-(3,5-dichlorophenyl)-4-(pyridin-4-yl)thiazol-2-amine [ No CAS ]
 

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[ 6221-13-2 ]

Chemical Structure| 5349-17-7

A237594 [5349-17-7]

2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide

Reason: Free-Salt