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Chemistry
Organic Building Blocks
Amines
diethylamino
N1-(2-(Diethylamino)ethyl)-N2,N2-diethylethane-1,2-diamine
Chemistry
Organic Building Blocks
Amines
diethylamino

[ CAS No. 123-12-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

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3d Animation Molecule Structure of 123-12-6
Chemical Structure| 123-12-6
Chemical Structure| 123-12-6
Structure of 123-12-6 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 123-12-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 123-12-6 ]
Product Citations

Product Citations

Li, Bowen ; Manan, Rajith Singh ; Liang, Shun-Qing , et al. DOI: PubMed ID:

Abstract: The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for mRNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.

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Product Details of [ 123-12-6 ]

CAS No. :123-12-6 MDL No. :MFCD00039880
Formula : C12H29N3 Boiling Point : -
Linear Structure Formula :NH(C2H4N(C2H5)2)2 InChI Key :UICCSKORMGVRCB-UHFFFAOYSA-N
M.W : 215.38 Pubchem ID :67154
Synonyms :

Safety of [ 123-12-6 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 UN#:2735
Hazard Statements:H315-H318-H335 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 123-12-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 123-12-6 ]

[ 123-12-6 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 123-12-6 ]
  • [ 5068-18-8 ]
  • [ 258885-11-9 ]
YieldReaction ConditionsOperation in experiment
72% With sodium cyanoborohydride In methanol at 20℃; for 16h;
Reference： [1]Karlsson, Magnus; Johansson, Maria; Andersson, Carlaxel [Journal of the Chemical Society, Dalton Transactions, 1999, # 23, p. 4187 - 4192]
  • 2
  • [ 123-12-6 ]
  • [ 67215-15-0 ]
  • [ 530-62-1 ]
  • N,N-bis[2-(diethylamino)ethyl]-N'-[2-(phenylsulfonyl)ethyl]urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran 64 N,N-Bis[2-(diethylamino)ethyl]-N'-[2-(phenylsulfonyl)ethyl]urea EXAMPLE 64 N,N-Bis[2-(diethylamino)ethyl]-N'-[2-(phenylsulfonyl)ethyl]urea A mixture of 4.84 g (0.0262 mole) of 2-phenylsulfonylethylamine and 4.90 g (0.030 mole) of 1,1'-carbonyldiimidazole in 400 ml of tetrahydrofuran was stirred at room temperature for 1 hr. A solution of 5.90 g (0.027 mole) of N'-[2-(diethylamino)ethyl]-N,N-diethyl-1,2-ethanediamine in 50 ml of tetrahydrofuran was added, and the solution was refluxed for 16 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and water. The methylene chloride solution was dried over sodium sulfate, and the solvent was removed in vacuo to give an oil. This was subjected to column chromatography (silica gel, gradiently eluted with methylene chloride-methanol) to give 7.64 g (60.78) of the title compound as an oil. Analysis: Calculated for C21 H38 N4 O3 S: C, 59.12; H, 8.98; N, 13.13. Found: C, 58.93; H, 9.13; N, 13.10. C, 58.89; H, 9.14; N, 13.03. 1 H-NMR (CDCl3)δ8.30(br s, H, NH), 8.00-7.73(m, 2H, ortho aromatic), 7.70-7.38(m, 3H, aromatic), 3.54-3.05(m, 8H, SO2 CH2 CH2 and N(CH2 CH2 NEt2)2), 2.77-2.28(m, 12H, N(CH2 CH2 N(CH2 CH3)2)2), 1.18-0.80(t, 12H, CH3).
Reference： [1]Current Patent Assignee: PFIZER INC - US4895840, 1990, A
  • 3
  • [ 123-12-6 ]
  • [ 13465-09-3 ]
  • [ 286935-93-1 ]
Reference： [1]Journal of Organometallic Chemistry,2000,vol. 602,p. 29 - 36
  • 4
  • sodium hexaflorophosphate [ No CAS ]
  • copper(II) nitrate trihydrate [ No CAS ]
  • [ 471-46-5 ]
  • [ 123-12-6 ]
  • [Cu2(μ-oxamido)(N,N,,N'',N''-tetraethyldiethylenetriamine)2](PF6)2 * H2O [ No CAS ]
Reference： [1]Inorganica Chimica Acta,1980,vol. 41,p. 155 - 160
  • 5
  • sodium hexaflorophosphate [ No CAS ]
  • copper(II) nitrate trihydrate [ No CAS ]
  • [ 471-47-6 ]
  • [ 123-12-6 ]
  • [Cu2(μ-oxamato)(N,N,,N'',N''-tetraethyldiethylenetriamine)2](PF6)2 * 1/2H2O [ No CAS ]
Reference： [1]Inorganica Chimica Acta,1980,vol. 41,p. 155 - 160
  • 6
  • [ 123-12-6 ]
  • [ 27905-45-9 ]
  • [ 1217872-89-3 ]
Reference： [1]Green Chemistry,2009,vol. 11,p. 1525 - 1529
  • 7
  • [ 123-12-6 ]
  • [ 120465-56-7 ]
  • [ 818-61-1 ]
  • C27H47N3O6 [ No CAS ]
Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 1443 - 1447
    Angew. Chem.,2014,vol. 126,p. 1467 - 1472,6

Tags: 123-12-6 synthesis path| 123-12-6 SDS| 123-12-6 COA| 123-12-6 purity| 123-12-6 application| 123-12-6 NMR| 123-12-6 COA| 123-12-6 structure

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Chemistry
Organic Building Blocks
Amines
diethylamino

Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Addition of an Amine to a Conjugated Enone • Amides Can Be Converted into Aldehydes • Amine Synthesis from Nitriles • Amine Synthesis from Nitriles • Amines Convert Acyl Chlorides into Amides • Amines Convert Esters into Amides • Azide Reduction by LiAlH4 • Azide Reduction by LiAlH4 • Basicity of Amines • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Chichibabin Reaction • Diazotization Reaction • DIBAL Attack Nitriles to Give Ketones • Enamine Formation • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hofmann Elimination • Hofmann Rearrangement • Hydride Reductions • Hydrolysis of Imines to Aldehydes and Ketones • Imine Formation from Amines and Aldehydes or Ketones • Leuckart-Wallach Reaction • Mannich Reaction • Methylation of Ammonia • Methylation of Ammonia • Nitrosation of Amines • Peptide Bond Formation with DCC • Petasis Reaction • Preparation of Amines • Preparation of LDA • Reactions of Amines • Reduction of an Amide to an Amine • Reduction of an Amide to an Amine • Reductive Amination • Reductive Amination • Ring Opening of Azacyclopropanes • Ring Opening of Azacyclopropanes • Ring Opening of Oxacyclobutanes • Specialized Acylation Reagents-Vilsmeier Reagent • Strecker Synthesis • Synthesis of 2-Amino Nitriles • Ugi Reaction
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