[ CAS No. 119479-32-2 ] Boc-DL-Allyl-Gly-OH

Cat. No.: A502111

2D 3D

Structure of 119479-32-2 * Storage: Keep in dark place,Sealed in dry,2-8°C

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Quality Control of [ 119479-32-2 ]

COA NMR CNMR HPLC LC-MS

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Alternatived Products of [ 119479-32-2 ]

Product Details of [ 119479-32-2 ]

CAS No. :	119479-32-2	MDL No. :	MFCD02682445
Formula :	C₁₀H₁₇NO₄	Boiling Point :	-
Linear Structure Formula :	CO₂HCHNHCO₂C₄H₉C₃H₅	InChI Key :	BUPDPLXLAKNJMI-UHFFFAOYSA-N
M.W :	215.25	Pubchem ID :	5166119
Synonyms :		Chemical Name :	2-((tert-Butoxycarbonyl)amino)pent-4-enoic acid

Safety of [ 119479-32-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 119479-32-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 119479-32-2 ]

[ 119479-32-2 ] Synthesis Path-Downstream 1~21

1
[ 119479-32-2 ]
[ 908093-98-1 ]
[ 74514-73-1 ]

Reference： [1]Journal of the American Chemical Society,1980,vol. 102,p. 4241
[2]Tetrahedron,1996,vol. 52,p. 7127 - 7136

2
[ 7685-44-1 ]
[ 58632-95-4 ]
[ 119479-32-2 ]

Reference： [1]Tetrahedron,1996,vol. 52,p. 7127 - 7136

3
[ 119479-32-2 ]
[ 10552-80-4 ]
[ 164298-39-9 ]

Reference： [1]Journal of the American Chemical Society,1996,vol. 118,p. 9606 - 9614

4
[ 7685-44-1 ]
[ 24424-99-5 ]
[ 119479-32-2 ]

Yield	Reaction Conditions	Operation in experiment
94%	With sodium hydroxide; In 1,4-dioxane; water; at 0℃; for 16h;	A solution of di-tert-butyl dicarbonate (11.4 g, 52.1 mmol) in 1,4-dioxane (15 mL) was slowly added to a second solution of 2-amino-5-pentenoic acid (5 g, 43.4 mmol) in 1 N NAOH (55 mL) at 0 C. After stirring for 16h, the solution was acidified with 5% HC1 to pH 2, and the resulting mixture was extracted with ethyl acetate (3 x 80 mL). The combined organic layers were dried OVER MGS04 and concentrated. The resulting residue was dissolved in DMF (50 mL) and treated with K2CO3 (7 g, 51 MMOL). After stirring for 15 min, the solution was cooled to 0 C and treated with iodomethane (3.4 mL, 51 mmol). After the addition was complete, the reaction mixture was stirred at room temperature for another 4 h, filtered and the resulting solid was washed with ethyl acetate (200 mL). The filtrate was washed successively with 5% aq HC1, sat. aq NaCl, dried over MGS04 and concented. Purification by flash column chromatography (5% ethyl acetate in heptane) provided 2-tert-Butoxycarbonylamino-5-pentenoic acid methyl ester (9.03 g, 94%) as an oil. 1H NMR (CDC13), 5.73 (m, 1 H), 5.12 (m, 1 H), 5.03 (m, 1 H), 4.38 (dd, J = 6, 12 Hz, 1 H), 3.74 (s, 3 H), 2.51 (m, 2 H), 1.46 (s, 9 H).
93%		rac. )-2-tert-Butoxycarbonylamiiio-pent-4-enoic acid (A); A solution of DL-allylglycine (20.2 g; 175mmol) in THF/H2O (670/670 ml) was cooled to 0 0C. NaHCO3 (44.11g; 525mmol) was added portionwise and BoC2O (68.8g; 315mmol) was added also portionwise. The reaction mixture was stirred at 0 C under N2 for 5 min, then at rt overnight. The pH of the milky mixture was adjusted to 4 by carefully addition of saturated citric acid at 0C, and the mixture was extracted with EtOAc. The combined org. layers were washed with brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The title compound was isolated as a white solid (35.1 g, 93%).
58%		A mixture of 2-aminopent-4-enoic acid (230mg, 2mmol), water (3mL) and tert-butanol (1mL) was treated with NaOH (88mg, 2.2mmol) and stirred until a clear solution was obtained (2-5min). Then Boc-anhydride (654mg, 3mmol) in tert-butanol (1.3mL) was added and stirred at r.t. overnight. The reaction mixture was extracted with diethyl ether (2×25mL). The combined ethereal layer was extracted with saturated Na2CO3 (2×25mL) and the combined aqueous layer was acidified with conc. HCl to pH 1. The aqueous layer was extracted with diethyl ether (3×25mL). The combined organic extracts were washed with brine (25mL), dried (MgSO4) and the solvent was evaporated to give a light brownish oil. Yield: 250mg (58%). 1H NMR (CDCl3) δ 1.42 (s, 9H, CH3), 2.57 (br m, 2H, H-3), 4.22 (br m, 0.25 H, H-2), 4.39 (br m, 0.75 H, H-2), 5.10 (br m, 0.75 H, NH), 5.13 (s, 1H, H-5cis), 5.18 (d, 3J=9Hz, H-5trans), 5.74 (m, 1H, H-4), 6.11 (br m, 0.25 H, NH), 8.24 (br s, 1H, CO2H). 13C NMR (CDCl3) δ 28.3 (q, CH3), 36.4 (t, C-3), 52.8 (d, C-2), 80.3 (s, O-C), 119.3 (t, C-5), 132.2 (d, C-4), 155.5 (s, Boc), 176.2 (s, C-1).

	With sodium hydroxide; potassium hydrogensulfate; In 1,4-dioxane; ethyl acetate;	Step 1: N-Boc-L-2-amino-4-pentenoic acid To a solution of L-2-amino-4-pentenoic acid (1.15 g, 10.0 mmol) in a mixture of dioxane (10 mL) and 1N NaOH (10 mL) was stirred in an ice bath. Di-tert-butyl pyrocarbonate (2.4 g, 11.0 mmol) was added and stirring was continued for 1 h. The solution was concentrated to 10 mL and 30 mL of EtOAc was added. The solution was made acidic (pH = 3) by the addition of solid KHSO4. The aqueous phase was extracted with EtOAc (2 x 10 mL) and dried over MgSO4. Evaporation of the solvent afforded the N-Boc protected amino acid as a white solid. 1H NMR (CDCl3) δ 5.75 (m, 1H), 5.20 (m, 2H), 5.05 (d, J=5.0 Hz, 1H), 4.40 (d, J=5.0 Hz, 1H), 4.57 (m, 2H), 1.47 (s, 9H).
		Reference Example 34 2-Amino-5-[4-(methyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester [Show Image] (1) Allylglycine (1.82 g) was dissolved in 1N aqueous sodium hydroxide solution (60 ml), and di-tert-butyl dicarbonate (4.15 g) was added thereto, followed by stirring the resulting mixture at room temperature for 11 hours. Di-tert-butyl dicarbonate (4.15 g) was further added to the reaction solution and the resulting mixture was stirred at room temperature overnight. After adding water to the reaction solution and washing it with ether, the solution was acidified with 3N hydrochloric acid. The solution was extracted twice with ethyl acetate. Organic layers were washed with saturated brine and dried over anhydrous sodium sulfate. After removing anhydrous sodium sulfate by filtration, the filtrate was concentrated. The residue was recrystallized from hexane/ethyl acetate mixed solvent to obtain N-Boc-allylglycine (3.09 g).
	With sodium hydroxide; In water; at 20℃;	Reference Example 34 2-Amino-5-[4-(methyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester [Show Image] (1) Allylglycine (1.82 g) was dissolved in 1N aqueous sodium hydroxide solution (60 ml), and di-tert-butyl dicarbonate (4.15 g) was added thereto, followed by stirring the resulting mixture at room temperature for 11 hours. Di-tert-butyl dicarbonate (4.15 g) was further added to the reaction solution and the resulting mixture was stirred at room temperature overnight. After adding water to the reaction solution and washing it with ether, the solution was acidified with 3N hydrochloric acid. The solution was extracted twice with ethyl acetate. Organic layers were washed with saturated brine and dried over anhydrous sodium sulfate. After removing anhydrous sodium sulfate by filtration, the filtrate was concentrated. The residue was recrystallized from hexane/ethyl acetate mixed solvent to obtain N-Boc-allylglycine (3.09 g).
		Allylglycine (1.82 g) was dissolved in 1N aqueous sodium hydroxide solution (60 ml), and di-tert-butyl dicarbonate (4.15 g) was added thereto, followed by stirring the resulting mixture at room temperature for 11 hours. Di-tert-butyl dicarbonate (4.15 g) was further added to the reaction solution and the resulting mixture was stirred at room temperature overnight. After adding water to the reaction solution and washing it with ether, the solution was acidified with 3N hydrochloric acid. The solution was extracted twice with ethyl acetate. Organic layers were washed with saturated brine and dried over anhydrous sodium sulfate. After removing anhydrous sodium sulfate by filtration, the filtrate was concentrated. The residue was recrystallized from hexane/ethyl acetate mixed solvent to obtain N-Boc-allylglycine (3.09 g).

Reference： [1]Organic Letters,2004,vol. 6,p. 3675 - 3678
[2]Bioorganic and Medicinal Chemistry Letters,2000,vol. 10,p. 711 - 713
[3]Journal of the Chemical Society. Perkin transactions I,1998,p. 2485 - 2499
[4]Patent: WO2004/99171,2004,A2 .Location in patent: Page 140-141
[5]Patent: WO2006/58546,2006,A1 .Location in patent: Page/Page column 13
[6]Journal of Fluorine Chemistry,2013,vol. 152,p. 144 - 156
[7]Tetrahedron Asymmetry,2005,vol. 16,p. 1141 - 1155
[8]Journal of Medicinal Chemistry,2004,vol. 47,p. 6740 - 6748
[9]Patent: WO2006/68213,2006,A1 .Location in patent: Page/Page column 56-57
[10]Patent: EP934064,2003,B1
[11]Patent: EP2033637,2009,A1 .Location in patent: Page/Page column 37
[12]Patent: EP2042171,2009,A1 .Location in patent: Page/Page column 36-37
[13]Patent: EP2039687,2009,A1 .Location in patent: Page/Page column 37

5
[ 98946-18-0 ]
[ 119479-32-2 ]
[ 149081-75-4 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1998,p. 2485 - 2499

6
[ 135722-56-4 ]
[ 119479-32-2 ]

Reference： [1]Chemical Communications,1998,p. 1679 - 1680
[2]Tetrahedron Letters,2000,vol. 41,p. 7409 - 7413

7
[ 119479-32-2 ]
[ 13515-93-0 ]
[ 889128-01-2 ]

Yield	Reaction Conditions	Operation in experiment
70%	With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 3.16667h;	(rαc.)-[(2-terMButoxycarbonylamino-pent-4-enoyl)methylamino]acetic acid methyl ester (B); PyBop (24.06g; 46.3 mmol) was added to a sol. of compound B (9.00 g; 42.04mmol) in DMF (200 mL) nnder N2 at rt. The sol. was stirred for 10 min at rt, and sarcosine methylester hydrochloride (6.46g; 46.3 mmol) and DIPEA (23.8 mL; 139 mmol) were added dropwise. The mixture was stirred at rt for 3 hours. EtOAc (400 mL) was added and the resulting organic phase was washed with brine (3x). The combined org. layers were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. The crude product was diluted again in EtOAc (150 mL) and the mixture was washed with water (2x). The combined org. layers were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (CH2Cl2/Me0H 50:1) yielded the title compound (8.82 g, 70%)

Reference： [1]Patent: WO2006/58546,2006,A1 .Location in patent: Page/Page column 13

8
[ 7685-44-1 ]
Boc-ON [ No CAS ]
[ 119479-32-2 ]

Reference： [1]Journal of the American Chemical Society,1980,vol. 102,p. 4241

9
[ 10340-91-7 ]
[ 119479-32-2 ]
[ 78-84-2 ]
cinnamyl amine resin [ No CAS ]
[1-(1-benzylcarbamoyl-2-methyl-propyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]-carbamic acid tert-butyl ester [ No CAS ]

Reference： [1]Tetrahedron,1999,vol. 55,p. 8189 - 8198

10
[ 10340-91-7 ]
[ 119479-32-2 ]
[ 100-52-7 ]
cinnamyl amine resin [ No CAS ]
[1-(benzylcarbamoyl-phenyl-methyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]-carbamic acid tert-butyl ester [ No CAS ]

Reference： [1]Tetrahedron,1999,vol. 55,p. 8189 - 8198

11
[ 104-53-0 ]
[ 10340-91-7 ]
[ 119479-32-2 ]
cinnamyl amine resin [ No CAS ]
[1-(1-benzylcarbamoyl-3-phenyl-propyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]-carbamic acid tert-butyl ester [ No CAS ]

Reference： [1]Tetrahedron,1999,vol. 55,p. 8189 - 8198

12
[ 119479-32-2 ]
[ 6638-79-5 ]
[ 603992-62-7 ]

Yield	Reaction Conditions	Operation in experiment
5.18 g	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 21 - 25℃; for 18h;Inert atmosphere;	[0213] Into a 250 mL round-bottom flask equipped with a magnetic stir bar and under N2 was added 2-((tert-butoxycarbonyl)amino)pent-4-enoic acid (5.00 g, 23.2 mmol, 1.0 equiv), N,O-dimethylhydroxylamine hydrochloride (2.49 g, 25.5 mmol, 1.1 equiv), HATU (10.6 g, 27.8 mmol, 1.2 equiv) and CH2Cl2 (50 mL). The reaction mixture was treated with EtN(iPr)2 (8.1 mL, 46.4 mmol, 2 equiv) and the suspension was stirred at room temperature for 18 h overnight. The reaction mixture was quenched with 1 M aqueous HCl solution (50 mL), and poured into a 250 mL separatory funnel containing water (50 mL). The mixture was extracted with CH2Cl2 (3 × 50 mL) and the combined organic layers were washed with brine (50 mL), dried over MgSO4, filtered and concentrated under reduced pressure. Purification by recrystallization from hot Et2O afforded a slight yellow solid, which was dried under vacuum (5.18 g).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2000,vol. 10,p. 711 - 713
[2]Journal of the American Chemical Society,2003,vol. 125,p. 10194 - 10205
[3]Patent: WO2017/222917,2017,A1 .Location in patent: Paragraph 0134; 0212; 0213

13
[ 53386-64-4 ]
[ 119479-32-2 ]
[benzyl-(2-tert-butoxycarbonylamino-pent-4-enoyl)-amino]-acetic acid methyl ester [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2003,vol. 68,p. 4486 - 4494

14
[ 119479-32-2 ]
[ 761401-97-2 ]
[ 761402-01-1 ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 7515 - 7524

15
[ 119479-32-2 ]
[ 74-89-5 ]
[ 274918-65-9 ]

Reference： [1]Organic Letters,2004,vol. 6,p. 3675 - 3678

16
[ 119479-32-2 ]
[ 161977-56-6 ]
[ 851626-48-7 ]

Reference： [1]Tetrahedron Asymmetry,2005,vol. 16,p. 1141 - 1155

17
[ 119479-32-2 ]
[ 74-88-4 ]
[ 106928-50-1 ]

Yield	Reaction Conditions	Operation in experiment
94%		A solution of di-tert-butyl dicarbonate (11.4 g, 52.1 mmol) in 1,4-dioxane (15 mL) was slowly added to a second solution of 2-amino-5-pentenoic acid (5 g, 43.4 mmol) in 1 N NAOH (55 mL) at 0 C. After stirring for 16h, the solution was acidified with 5% HC1 to pH 2, and the resulting mixture was extracted with ethyl acetate (3 x 80 mL). The combined organic layers were dried OVER MGS04 and concentrated. The resulting residue was dissolved in DMF (50 mL) and treated with K2CO3 (7 g, 51 MMOL). After stirring for 15 min, the solution was cooled to 0 C and treated with iodomethane (3.4 mL, 51 mmol). After the addition was complete, the reaction mixture was stirred at room temperature for another 4 h, filtered and the resulting solid was washed with ethyl acetate (200 mL). The filtrate was washed successively with 5% aq HC1, sat. aq NaCl, dried over MGS04 and concented. Purification by flash column chromatography (5% ethyl acetate in heptane) provided 2-tert-Butoxycarbonylamino-5-pentenoic acid methyl ester (9.03 g, 94%) as an oil. 1H NMR (CDC13), 5.73 (m, 1 H), 5.12 (m, 1 H), 5.03 (m, 1 H), 4.38 (dd, J = 6, 12 Hz, 1 H), 3.74 (s, 3 H), 2.51 (m, 2 H), 1.46 (s, 9 H).
79%	With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20℃; for 7h;	Methyl N-Boc-2-aminopent-4-enoic acid (250mg, 1.163mmol) was dissolved in dry DMF (3mL) and K2CO3 (241mg, 1.744mmol) was added. The suspension was cooled to 0C and methyl iodide (330mg, 2.326mmol) was added slowly with stirring. Stirring was continued at 0C for 3h and at r.t. for 4 more hours. Water (70mL) was added and the solution was extracted with ethyl acetate (3×25mL). The combined organic layers were washed with brine (2×25mL) and dried (MgSO4). The solvent was evaporated to give a light brownish oil. Yield: 210mg (79%). 1H NMR (CDCl3): δ 1.44 (s, 9H, CH3), 2.51 (br m, 2H, H-3), 3.74 (s, 3H, OCH3), 4.38 (br m, 1H, NH), 5.03 (br m, 1 H, H-2), 5.07 (s, 1H, H-5cis), 5.10 (m, 1H, H-5trans), 5.65 (m, 1H, H-4), 13C NMR (CDCl3): δ 28.3 (q, CH3), 36.7 (t, C-3), 52.0 (d, C-2), 52.8 (q, OCH3), 79.7 (s, O-C), 118.9 (t, C-5), 132.3 (d, C-4), 155.1 (s, Boc), 172.4 (s, C-1).
	With potassium carbonate; In acetone; for 4h;Reflux;	2-tert-Butoxycarbonylamino-pent-4-enoic acid (9.3 g, 43.3 mmol) in acetone (70 mL) is treated with solid potassium carbonate (11.9 g, 86.6 mmol) followed by methyl iodide (5.4 mL, 86.6 mmol). The resulting mixture is heated to reflux for 4 h and then allowed to cool to RT. The solvent is removed in vacuo and the crude residue is dissolved in EtOAc, washed with water, saturated sodium hydrogen carbonate solution, brine, dried (MgSO4) and concentrated in vacuo. The crude residue is purified by flash chromatography (SiCh, zso-hexane:EtOAc 7:3) to afford the title compound as a light-yellow oil.

Reference： [1]Patent: WO2004/99171,2004,A2 .Location in patent: Page 140-141
[2]Journal of Fluorine Chemistry,2013,vol. 152,p. 144 - 156
[3]Journal of Medicinal Chemistry,2004,vol. 47,p. 6740 - 6748
[4]Patent: WO2009/138378,2009,A1 .Location in patent: Page/Page column 43

18
[ 764622-98-2 ]
[ 119479-32-2 ]
(1S,3S,4R)-2-(2-tert-Butoxycarbonylamino-pent-4-enoyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 5553 - 5556

19
[ 119479-32-2 ]
[ 107-11-9 ]
(1-allylcarbamoylbut-3-enyl)carbamic acid tert-butyl ester [ No CAS ]

Reference： [1]Journal of Organometallic Chemistry,2006,vol. 691,p. 5487 - 5496

20
[ 846034-31-9 ]
[ 119479-32-2 ]
[ 959408-01-6 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethylmorpholine;; 1-hydroxy-7-aza-benzotriazole; HATU; In dichloromethane; at 20℃; for 12h;	STEP B: Boc-Allyglycine-N-(2,4-dimethoxybenzyl)allylglycine methylester N-2,4-dimethoxybenzyl allylglycine methyl ester (as the free base) (7.79 g, 27.9 mmol) was dissolved in methylene chloride (90 mL), and then Boc-allyglycine-OH (6.0 g, 27.9 mmol), HOAt (3.8 g, 27.9 mmol), HATU (10.6 g, 27.9 mmol) and N-ethyl morpholine (3.6 mL, 27.9 mmol) were added to the reaction mixture. The reaction was allowed to proceed for 12 hours at room temperature after which time the solvent was removed and the crude mixture was dissolved/suspended in diethyl ether. The crude reaction was filtered through a pad of Celite to remove solid byproducts. The Celite was washed 3* with diethyl ether after which the combined ether solutions were poured into a separatory funnel and washed three times with 10% Na2CO3 in water, one time with saturated brine solution, three times with 1 N HCl and one time saturated brine. The organic layer was dried with anhydrous magnesium sulfate and the solvent was removed under reduced pressure. Final purification was accomplished by flash chromatography (3:1 hexanes/ethyl acetate) to yield a clear, colorless oil. 1H NMR (300 Hz, CDCl3, δ) 7.12, (d, 1H, 9 Hz); 6.45, (m, 2H); 5.7, (m, 1H), 5.35 (d, 1H, 9 Hz); 5.0, (m, 5H); 4.65, (d, 1H, 15 Hz); 4.35, (d, 1H, 15 Hz); 4.05, (m, 1H); 3.75, (m, 6H); 3.55, (s, 3H), 2.7, (m, 1H); 2.55 (m, 2H); 2.35 (m, 1H); 1.5 (s, 9H) HPLC Rt=3.95 MS m/z (% relative intensity, ion): 477 (30, M+H+), 499 (30, M+Na+) 151 (100, M+ of DMB)

Reference： [1]Patent: US2008/70919,2008,A1 .Location in patent: Page/Page column 21-22

21
[ 4383-22-6 ]
[ 119479-32-2 ]
[ 918306-87-3 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 8323 - 8331
[2]Organic Letters,2014,vol. 16,p. 3712 - 3715

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Technical Information

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P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 119479-32-2 ] Boc-DL-Allyl-Gly-OH

Quality Control of [ 119479-32-2 ]

Related Doc. of [ 119479-32-2 ]

Product Details of [ 119479-32-2 ]

Safety of [ 119479-32-2 ]

Application In Synthesis of [ 119479-32-2 ]

[ 119479-32-2 ] Synthesis Path-Downstream 1~21

Technical Information

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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